Summary Information - CYP2A6
    Gene Database Entries for CYP2A6
    Other CYP2A6 Related Resources
    CYP2A6 and Lung Cancer
    CYP2A6 and Nicotine Metabolism
    Cytochromes and Cyclophosphamide / Ifosfamide Activation
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CYP2A6; Cytochrome P450, subfamily IIA (phenobarbital-inducible), polypeptide 6

Location: 19q13.2

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OMIM
GeneCard (Weizmann Institute)
Human Gene Mutation Database (Cardiff, UK)
Swiss-Prot
Locus Link
UniGene
GenAtlas
GDB
Nomenclature (search for CYP2A6)

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Search Medline for related articles (PubMed)

Medline Search: cancer AND gene AND CYP2A6[TI] (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

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Kamataki T, et al. Genetic polymorphism of CYP2A6 in relation to cancer. Mutat Res 1999; 428(1-2):125-30    Related articles (PubMed)

Miyamoto M, et al. CYP2A6 gene deletion reduces susceptibility to lung cancer. Biochem Biophys Res Commun. 1999; 261(3):658-60    Related articles (PubMed)

Medline Search: CYP2A6 AND lung cancer (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

Related Resources
Lung Cancer Genetics
Lung Cancer : Clinical and Epidemiological Information

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Kitagawa K, et al. The significance of the homozygous CYP2A6 deletion on nicotine metabolism: a new genotyping method of CYP2A6 using a single PCR-RFLP. Biochem Biophys Res Commun. 1999; 262(1):146-51    Related articles (PubMed)

Medline Search: CYP2A6 AND nicotine (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

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Chang TK, et al. Differential activation of cyclophosphamide and ifosphamide by cytochromes P-450 2B and 3A in human liver microsomes. Cancer Res 1993; 53(23):5629-37    Related articles (PubMed)

Lohr M, et al. Cell therapy using microencapsulated 293 cells transfected with a gene construct expressing CYP2B1, an ifosfamide converting pancreatic carcinoma: a phase I/II study. J Mol Med 1999; 77(4):393-8    Related articles

Muller P, et al. Injection of encapsulated cells producing an ifosfamide-activating cytochrome P450 for targeted chemotherapy to pancreatic tumors. Ann N Y Acad Sci 1999; 880:337-51    Related articles (PubMed)

Aghi M, et al. Multimodal cancer treatment mediated by a replicating oncolytic virus that delivers the oxazaphosphorine/rat cytochrome P450 2B1 and ganciclovir/herpes simplex virus thymidine kinase gene therapies. Cancer Res. 1999; 59(16):3861-5    Related articles (PubMed)

Medline Search: (cytochromes OR P450) AND (ifosfamide OR cyclophosphamide) (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

Related Resources

Chemotherapy Resources

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