TOC - Tylosis with oesophageal cancer - aka: TOCG

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TOC; Tylosis with oesophageal cancer (17q24)
TOC Menu Summary Information - TOC Gene Database Entries for TOC Other TOC Related Resources TOC Locus Implicated in Esophageal Cancer Feedback / suggest a new topic for TOC
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Summary Information
TOC; Tylosis with oesophageal cancer Location: 17q24 Alias: TOCG Return to TOC Contents
Gene Database Entries for TOC
OMIM GeneCard (Weizmann Institute) Locus Link GenAtlas GDB Nomenclature (search for TOC) Return to TOC Contents
Other Related Resources
Search Medline for related articles (PubMed) *Medline Search:* cancer AND gene AND (TOC[TI] OR TOCG[TI]) (PubMed) Limit search to: [Last Year] Limit search to: [Last 2 Years] Limit search to: [Reviews] Return to TOC Contents
TOC Locus Implicated in Esophageal Cancer
An increased risk of esophageal cancer has been associated with tylosis (a rare skin condition also known as focal non-epidermolytic palmoplantar keratoderma) in 3 large kindreds in the UK, the American Midwest and Germany. Genomic mapping of this familial disease has identified candidate genes implicated in sporadic esophageal cancer. In particular, LOH 17q is frequent feature of sporadic esophageal cancer and linkage and haplotype analyses of the UK and US families with tylosis and oesophageal cancer implicate the TOC gene locus located at 17q25. Risk JM, et al. The tylosis esophageal cancer (TOC) locus: more than just a familial cancer gene. Dis Esophagus. 1999;12(3):173-6 Related articles (PubMed) Ellis A, et al. Tylosis associated with carcinoma of the oesophagus and oral leukoplakia in a large Liverpool family--a review of six generations. Eur J Cancer 1994;30B(2):102-12 Related articles (PubMed) *Medline Search:* esophageal cancer AND TOC (PubMed) Limit search to: [Last Year] Limit search to: [Last 2 Years] Limit search to: [Reviews] Related Resources FTOCS - Familial Tylosis and Oesophageal Cancer Study (Molecular Genetics and Oncology Group, University of Liverpool, UK) A study into a rare form of oesophageal cancer, associated with an inherited skin condition called ‘tylosis’. The site includes information for patients, doctors and scientists. Esophageal Cancer Genetics Esophageal Cancer : Clinical and Epidemiological Information Return to TOC Contents
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TOC; Tylosis with oesophageal cancer