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CYP2B; Cytochrome P450, subfamily IIB (phenobarbital-inducible) (19q13.1-q13.2)
CYP2B Menu

    Summary Information - CYP2B
    Gene Database Entries for CYP2B
    Other CYP2B Related Resources
    Cytochromes and Cyclophosphamide / Ifosfamide Activation
    CYP2B and Gene Therapy (Experimental)
    Feedback / suggest a new topic for CYP2B


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  Summary Information

CYP2B; Cytochrome P450, subfamily IIB (phenobarbital-inducible)

Location: 19q13.1-q13.2
Alias: CYP2B1

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  Gene Database Entries for CYP2B

OMIM
GeneCard (Weizmann Institute)
Locus Link
GDB
Nomenclature (search for CYP2B)

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  Other Related Resources

Search Medline for related articles (PubMed)
  • Medline Search: cancer AND gene AND (CYP2B[TI] OR CYP2B1[TI]) (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]
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      Cytochromes and Cyclophosphamide / Ifosfamide Activation

  • Chang TK, et al. Differential activation of cyclophosphamide and ifosphamide by cytochromes P-450 2B and 3A in human liver microsomes. Cancer Res 1993; 53(23):5629-37    Related articles (PubMed)

  • Lohr M, et al. Cell therapy using microencapsulated 293 cells transfected with a gene construct expressing CYP2B1, an ifosfamide converting pancreatic carcinoma: a phase I/II study. J Mol Med 1999; 77(4):393-8    Related articles

  • Muller P, et al. Injection of encapsulated cells producing an ifosfamide-activating cytochrome P450 for targeted chemotherapy to pancreatic tumors. Ann N Y Acad Sci 1999; 880:337-51    Related articles (PubMed)

  • Aghi M, et al. Multimodal cancer treatment mediated by a replicating oncolytic virus that delivers the oxazaphosphorine/rat cytochrome P450 2B1 and ganciclovir/herpes simplex virus thymidine kinase gene therapies. Cancer Res. 1999; 59(16):3861-5    Related articles (PubMed)

  • Medline Search: (cytochromes OR P450) AND (ifosfamide OR cyclophosphamide) (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

    Related Resources
    Chemotherapy Resources

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  •   CYP2B and Gene Therapy (Experimental)

  • Lohr M, et al. Cell therapy using microencapsulated 293 cells transfected with a gene construct expressing CYP2B1, an ifosfamide converting pancreatic carcinoma: a phase I/II study. J Mol Med 1999; 77(4):393-8    Related articles

  • Muller P, et al. Injection of encapsulated cells producing an ifosfamide-activating cytochrome P450 for targeted chemotherapy to pancreatic tumors. Ann N Y Acad Sci 1999; 880:337-51    Related articles (PubMed)

  • Aghi M, et al. Multimodal cancer treatment mediated by a replicating oncolytic virus that delivers the oxazaphosphorine/rat cytochrome P450 2B1 and ganciclovir/herpes simplex virus thymidine kinase gene therapies. Cancer Res. 1999; 59(16):3861-5    Related articles (PubMed)

  • Medline Search: (CYP2B1 OR CYP2B) AND cancer AND gene therapy (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

    Return to CYP2B Contents
     

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