 Summary Information
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Location: 19q13.3-q13.4
BAX proteins regulate apoptosis in cellular pathways involving both BCL2 and TP53
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| Gene Database Entries for BAX
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OMIM
GeneCard (Weizmann Institute)
Tumor Gene Database
Genbank
Swiss-Prot
Locus Link
UniGene
GenAtlas
GDB
Nomenclature (search for BAX)
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| Other Related Resources
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- Search Medline for related articles (PubMed)
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- Medline Search: cancer AND gene AND BAX[TI] (PubMed)
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| BAX and Apoptosis
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Oltvai ZN, et al. Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 1993; 74(4):609-19 Related articles (PubMed)
Medline Search: bax AND apoptosis (PubMed)
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| BAX and Leukaemia
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Meijerink JP, et al. Hematopoietic malignancies demonstrate loss-of-function mutations of BAX. Blood 1998; 91(8):2991-7 Related articles (PubMed)
Medline Search: bax AND leukemia (PubMed)
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 Leukaemia Genetics
Leukaemia : Clinical and Epidemiological Information
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| BAX and Childhood Acute Lymphocytic Leukemia
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Hogarth LA, Hall AG Increased BAX expression is associated with an increased risk of relapse in childhood acute lymphocytic leukemia. Blood 1999; 93(8):2671-8 Related articles (PubMed)
Findley HW, et al. Expression and regulation of Bcl-2, Bcl-xl, and Bax correlate with p53 status and sensitivity to apoptosis in childhood acute lymphoblastic leukemia. Blood 1997; 89(8):2986-93 Related articles (PubMed)
Medline Search: bax AND childhood acute lymphocytic leukemia (PubMed)
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Acute Lymphocytic Leukaemia Genetics
Acute Lymphocytic Leukaemia : Clinical and Epidemiological Information
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| BAX and Chronic Lymphocytic Leukemia
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Molica S, et al. Increased bcl-2/bax ratio in B-cell chronic lymphocytic leukemia is associated with a progressive pattern of disease. Haematologica 1998; 83(12):1122-4 Related articles (PubMed)
Medline Search: bax AND chronic lymphocytic leukemia (PubMed)
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Chronic Lymphocytic Leukaemia Genetics
Chronic Lymphocytic Leukaemia : Clinical and Epidemiological Information
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| BAX and Colorectal Cancer
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Rampino N, et al. Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype. Science 1997; 275(5302):967-9 Related articles (PubMed)
Medline Search: bax AND colorectal cancer (PubMed)
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ColoRectal Cancers Genetics
ColoRectal Cancers : Clinical and Epidemiological Information
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| BAX and Pancreatic Cancer
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Miyamoto Y, et al. Immunohistochemical analysis of Bcl-2, Bax, Bcl-X, and Mcl-1 expression in pancreatic cancers. Oncology 1999; 56(1):73-82 Related articles (PubMed)
Medline Search: bax AND pancreatic cancer (PubMed)
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Pancreatic Cancer Genetics
Pancreatic Cancer : Clinical and Epidemiological Information
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| BAX and Gastric Carcinoma
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Iacopetta BJ, et al. Gastric carcinomas with microsatellite instability: clinical features and mutations to the TGF-beta type II receptor, IGFII receptor, and BAX genes. J Pathol 1999; 187(4):428-32 Related articles (PubMed)
Medline Search: gastric cancer AND bax AND gene (PubMed)
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Stomach (Gastric) Cancer Genetics
Stomach (Gastric) Cancer : Clinical and Epidemiological Information
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| BAX Gene Transfer (Experimental)
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Kagawa S, et al. A binary adenoviral vector system for expressing high levels of the proapoptotic gene bax. Gene Ther 2000;7(1):75-9 Related articles (PubMed)
Coll JL, et al. Antitumor activity of bax and p53 naked gene transfer in lung cancer: in vitro and in vivo analysis. Hum Gene Ther. 1998 Sep 20;9(14):2063-74. Related articles (PubMed)
Medline Search: bax[TI] AND cancer AND gene therapy (PubMed)
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[Home] This page created: 17/11/1999 Last revised: 29/04/2003 © Copyright 1999-
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