 Summary Information
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Location: 19q13.2
Alias: CGM2
CGM2 protein expression is downregulated in colorectal cancers.
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| Gene Database Entries for CEACAM7
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OMIM (search for CEACAM7)
GeneCard (Weizmann Institute)
Genbank
Swiss-Prot
Locus Link
UniGene
GenAtlas
GDB
Nomenclature (search for CEACAM7)
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| Other Related Resources
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- Search Medline for related articles (PubMed)
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- Medline Search: cancer AND gene AND (CEACAM7[TI] OR CGM2[TI]) (PubMed)
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| The Carcinoembryonic Antigen (CEA) Family
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Carcinoembryonic antigen (CEA) is one of the most frequently used serum tumour markers for carcinoma, particularly in colorectal cancer. It is useful in the diagnosis and monitoring of cancer, however, specificity for CEA assays is not absolute. Therefore,
it is often used in conjunction with tests for other markers. There are are infact a number of genes and pseudogenes composing a CEA family which are subdivided into CEACAM and PSG (pregnancy-specific glycoprotein) genes.
Beauchemin, N et al. Redefined Nomenclature for Members of the Carcinoembryonic Antigen Family Exp Cell Res, 1999; 252(2): 243-249
Sanders DS, Kerr MA Lewis blood group and CEA related antigens; coexpressed cell-cell adhesion molecules with roles in the biological progression and dissemination of tumours. [Review] Mol Pathol 1999;52(4):174-8 Related articles (PubMed)
Mayer A, et al. Taking engineered anti-CEA antibodies to the clinic. J Immunol Methods 1999 Dec 10;231(1-2):261-73 Related articles (PubMed)
Hammarstrom S The carcinoembryonic antigen (CEA) family: structures, suggested functions and expression in normal and malignant tissues. Semin Cancer Biol 1999;9(2):67-81 Related articles (PubMed)
Mitchell EP Role of carcinoembryonic antigen in the management of advanced colorectal cancer. Semin Oncol 1998;25(5 Suppl 11):12-20 Related articles (PubMed)
Medline Search: carcinoembryonic antigen (PubMed)
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- Related Resources
- The CEA Family Home Page (Germany) This English language site is hosted by the Institute of Molecular Medicine and Cell Research, Freiburg University. It contains detailed information on the Carcinoembryonic Antigen Family, CEA splice variants, publications etc.
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| CEACAM7 Expression in Colorectal Cancer
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Nollau P, et al. Dysregulation of carcinoembryonic antigen group members CGM2, CD66a (biliary glycoprotein), and nonspecific cross-reacting antigen in colorectal carcinomas. Comparative analysis by northern blot and in situ hybridization. Am J Pathol. 1997; 151(2):521-30 Related articles (PubMed)
Thompson J, et al. Down-regulation of carcinoembryonic antigen family member 2 expression is an early event in colorectal tumorigenesis. Cancer Res. 1997; 57(9):1776-84 Related articles (PubMed)
Thompson J, et al. CGM2, a member of the carcinoembryonic antigen gene family is down-regulated in colorectal carcinomas. J Biol Chem 1994; 269(52):32924-31 Related articles (PubMed)
Medline Search: colorectal cancer AND (cgm2 OR ceacam7) (PubMed)
Limit search to: [Last Year] Limit search to: [Last 2 Years]
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- Related Resources
 ColoRectal Cancers Genetics
ColoRectal Cancers : Clinical and Epidemiological Information
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