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  Chromosome 7

Genes Linked with Cancer (100)

How to use this data table Click on the gene name for detailed information. Type in the Search box e.g. 'germline' or 'Breast Cancer' to search within Chromosome 7; or Sort by clicking on a column heading e.g. 'Gene'.

Gene Location Aliases Abnormalities Implicated in
EGFR 7p12 ERBB, HER1, mENA, ERBB1, PIG61, NISBD2Germline & Somatic
Amplification
-Astrocytoma, Childhood
-Brain Tumours, Childhood
-Cervical Cancer
-Colorectal Cancer
-Esophageal Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
-Synovial Sarcoma
SEMA3A 7p12.1 HH16, SemD, COLL1, SEMA1, SEMAD, SEMAL, coll-1, Hsema-I, SEMAIII, Hsema-III-Breast Cancer
-Lung Cancer
-Prostate Cancer
IKZF1 7p12.2 IK1, LYF1, LyF-1, IKAROS, PPP1R92, PRO0758, ZNFN1A1, Hs.54452Somatic-Acute Lymphocytic Leukaemia (ALL)
IGFBP3 7p12.3 IBP3, BP-53-Breast Cancer
-Colorectal Cancer
-Liver Cancer
-Small Cell Lung Cancer
-Prostate Cancer
-Skin Cancer
-Urinary System Cancers
IGFBP1 7p12.3 AFBP, IBP1, PP12, IGF-BP25, hIGFBP-1-Breast Cancer
-Liver Cancer
-Ovarian Cancer
-Prostate Cancer
CCM2 7p13 OSM, C7orf22, PP10187-Brain and CNS Tumours
-Brain Tumours, Childhood
PPIA 7p13 CYPA, CYPH, HEL-S-69p-Breast Cancer
-Cervical Cancer
-Kidney Cancer
-Liver Cancer
-Ovarian Cancer
-Prostate Cancer
GLI3 7p13 PHS, ACLS, GCPS, PAPA, PAPB, PAP-A, PAPA1, PPDIV, GLI3FL, GLI3-190-Bladder Cancer
-Colorectal Cancer
-Basal Cell Carcinoma (BCC) - Skin
AQP1 7p14 CO, CHIP28, AQP-CHIP-Brain Tumours, Childhood
-Breast Cancer
-Lung Cancer
-Ovarian Cancer
-Salivary Gland Cancer
-Stomach Cancer
TRG 7p14 TCRG, TRG@-Breast Cancer
-Endometrial Cancer
-Melanoma
AMPH 7p14-p13 AMPH1-Breast Cancer
SFRP4 7p14.1 FRP-4, FRPHE, sFRP-4-Acute Myeloid Leukaemia
-Colorectal Cancer
-Endometrial Cancer
-Stomach Cancer
SEPT7 7p14.2 CDC3, CDC10, SEPT7A, NBLA02942-Brain Stem Glioma, Childhood
-Brain Tumours, Childhood
-Neuroblastoma
RALA 7p15-p13 RAL-Bladder Cancer
-Lung Cancer
-Pancreatic Cancer
HNRNPA2B1 7p15 RNPA2, HNRPA2, HNRPB1, SNRPB1, HNRNPA2, HNRNPB1, IBMPFD2, HNRPA2B1Somatic-Breast Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
-von Hippel-Lindau Disease
JAZF1 7p15.2-p15.1 TIP27, ZNF802Somatic-Endometrial Cancer
-Prostate Cancer
-Soft Tissue Sarcoma
-Uterine Sarcoma
HOXA13 7p15.2 HOX1, HOX1JSomatic-Acute Myeloid Leukaemia
-Bladder Cancer
-Cervical Cancer
-Esophageal Cancer
-Leukaemia
-Liver Cancer
HOXA11 7p15.2 HOX1, HOX1ISomatic-Acute Myeloid Leukaemia
-Leukaemia
-Lung Cancer
-Ovarian Cancer
-Skin Cancer
-Wilms Tumour
HOXA9 7p15.2 HOX1, ABD-B, HOX1G, HOX1.7Somatic
Translocation
-Acute Myeloid Leukaemia
-Chronic Myelogenous Leukemia
HOXA10 7p15.2 PL, HOX1, HOX1H, HOX1.8-Acute Myeloid Leukaemia
-Breast Cancer
-Leukaemia
HOXA7 7p15.2 ANTP, HOX1, HOX1A, HOX1.1-Acute Lymphocytic Leukaemia (ALL)
-Acute Myeloid Leukaemia
-Cervical Cancer
-Leukaemia
-Ovarian Cancer
HOXA5 7p15.2 HOX1, HOX1C, HOX1.3-Acute Myeloid Leukaemia
-Breast Cancer
-Leukaemia
-Lung Cancer
-Lung Cancer, Non-Small Cell
HOXA1 7p15.3 BSAS, HOX1, HOX1F-Breast Cancer
-Lung Cancer
-Skin Cancer
IL6 7p21 HGF, HSF, BSF2, IL-6, IFNB2-Breast Cancer
-Liver Cancer
-Lung Cancer
-Prostate Cancer
-Vulvar Cancer
-Waldenstrom's Macroglobulinemia
MACC1 7p21.1 7A5, SH3BP4L-Cervical Cancer
-Colorectal Cancer
-Liver Cancer
-Lung Cancer
TWIST1 7p21.2 CRS, CSO, SCS, ACS3, CRS1, BPES2, BPES3, TWIST, bHLHa38-Breast Cancer
-Colorectal Cancer
-Lung Cancer
-Oral Cavity Cancer
ETV1 7p21.3 ER81Somatic
Translocation
-Ewing's Sarcoma
-Gastrointestinal Stromal Tumors
-Melanoma
-Prostate Cancer
AGR2 7p21.3 AG2, GOB-4, HAG-2, XAG-2, PDIA17, HEL-S-116-Breast Cancer
-Colorectal Cancer
-Pancreatic Cancer
-Prostate Cancer
RAC1 7p22 MIG5, Rac-1, TC-25, p21-Rac1-Brain Tumours, Childhood
-Breast Cancer
-Colorectal Cancer
-Lung Cancer
PDGFA 7p22 PDGF1, PDGF-A-Brain and CNS Tumours
-Brain Tumours, Childhood
-Neuroblastoma
-Uterine Sarcoma
ACTB 7p22 BRWS1, PS1TP5BP1-Bladder Cancer
-Breast Cancer
-Kidney Cancer
-Liver Cancer
-Lung Cancer
CARD11 7p22 PPBL, BENTA, BIMP3, IMD11, CARMA1Somatic
MAD1L1 7p22 MAD1, PIG9, TP53I9, TXBP181-Bladder Cancer
-Breast Cancer
-Colorectal Cancer
-Lung Cancer
-Prostate Cancer
-Stomach Cancer
FSCN1 7p22 HSN, SNL, p55, FAN1-Bladder Cancer
-Breast Cancer
-Colorectal Cancer
-Esophageal Cancer
-Stomach Cancer
PMS2 7p22.2 PMSL2, HNPCC4, PMS2CLGermline-Acute Lymphocytic Leukaemia (ALL)
-Hereditary Nonpolyposis Colorectal Cancer (HNPCC)
-Ovarian Cancer
-Skin Cancer
-Thyroid Cancer
GPER1 7p22.3 mER, CEPR, GPER, DRY12, FEG-1, GPR30, LERGU, LyGPR, CMKRL2, LERGU2, GPCR-Br-Breast Cancer
-Endometrial Cancer
-Ovarian Cancer
-Testicular Cancer
CD36 7q11.2 FAT, GP4, GP3B, GPIV, CHDS7, PASIV, SCARB3, BDPLT10-Acute Myeloid Leukaemia
-Breast Cancer
-Chronic Myelogenous Leukemia
-Leukaemia
SBDS 7q11.21 SDS, SWDS, CGI-97Germline-Acute Myeloid Leukaemia
-Leukaemia
-Myelodysplastic Syndromes
-Prostate Cancer
CLDN3 7q11.23 RVP1, HRVP1, C7orf1, CPE-R2, CPETR2-Cervical Cancer
-Esophageal Cancer
-Lung Cancer
-Ovarian Cancer
-Stomach Cancer
-Vulvar Cancer
ELN 7q11.23 WS, WBS, SVASSomatic-Acute Myeloid Leukaemia
-Bladder Cancer
-Brain Tumours, Childhood
-Chronic Myelogenous Leukemia
HIP1 7q11.23 HIP-I, ILWEQSomatic-Colorectal Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
-Prostate Cancer
LIMK1 7q11.23 LIMK, LIMK-1-Breast Cancer
-Lung Cancer
-Prostate Cancer
-Thyroid Cancer
HSPB1 7q11.23 CMT2F, HMN2B, HSP27, HSP28, Hsp25, SRP27, HS.76067, HEL-S-102-Breast Cancer
-Lung Cancer
-Melanoma
-Prostate Cancer
DTX2P1-UPK3B 7q11.23 PMSR6, PMS2L11, PMS2P11-Acute Myeloid Leukaemia
-Mesothelioma
CLDN4 7q11.23 CPER, CPE-R, CPETR, CPETR1, WBSCR8, hCPE-R-Breast Cancer
-Ovarian Cancer
-Pancreatic Cancer
-Stomach Cancer
-Uterine Sarcoma
CDK6 7q21-q22 MCPH12, PLSTIRESomatic-Eye Cancer
-Melanoma
-Retinoblastoma
-Skin Cancer
-Stomach Cancer
-Thyroid Cancer
PEG10 7q21 EDR, HB-1, Mar2, MEF3L, Mart2, RGAG3-Liver Cancer
-Uterine Sarcoma
-Wilms Tumour
AKAP9 7q21-q22 LQT11, PRKA9, AKAP-9, CG-NAP, YOTIAO, AKAP350, AKAP450, PPP1R45, HYPERION, MU-RMS-40.16ASomatic-Breast Cancer
-Colorectal Cancer
-Lung Cancer
-Skin Cancer
-Thyroid Cancer
CYP3A5 7q21.1 CP35, PCN3, CYPIIIA5, P450PCN3-Breast Cancer
-Prostate Cancer
-Soft Tissue Sarcoma
-Testicular Cancer
ABCB4 7q21.1 GBD1, ICP3, MDR2, MDR3, PGY3, ABC21, MDR2/3, PFIC-3
CYP3A4 7q21.1 HLP, CP33, CP34, CYP3A, NF-25, CYP3A3, P450C3, CYPIIIA3, CYPIIIA4, P450PCN1-Breast Cancer
-Lung Cancer
-Prostate Cancer
-Soft Tissue Sarcoma
-Testicular Cancer
HGF 7q21.1 SF, HGFB, HPTA, F-TCF, DFNB39-Bladder Cancer
-Breast Cancer
-Liver Cancer
-Lung Cancer
-Prostate Cancer
-Rhabdomyosarcoma
ABCB1 7q21.12 CLCS, MDR1, P-GP, PGY1, ABC20, CD243, GP170-Breast Cancer
-Cervical Cancer
-Eye Cancer
-Stomach Cancer
STEAP2 7q21.13 STMP, IPCA1, PUMPCn, STAMP1, PCANAP1-Colorectal Cancer
-Prostate Cancer
KRIT1 7q21.2 CAM, CCM1-Brain and CNS Tumours
-Brain Tumours, Childhood
-Skin Cancer
MCM7 7q21.3-q22.1 MCM2, CDC47, P85MCM, P1CDC47, PNAS146, PPP1R104, P1.1-MCM3-Breast Cancer
-Cervical Cancer
-Prostate Cancer
-Stomach Cancer
PON1 7q21.3 ESA, PON, MVCD5-Brain Tumours, Childhood
-Breast Cancer
-Prostate Cancer
ACHE 7q22 YT, ACEE, ARACHE, N-ACHE-Bone Cancer (primary)
-Breast Cancer
-Gastrointestinal Stromal Tumors
-Liver Cancer
-Lung Cancer
-Ovarian Cancer
-Pancreatic Cancer
MUC3A 7q22 MUC3, MUC-3A-Acute Myeloid Leukaemia
-Breast Cancer
-Colorectal Cancer
-Gastrointestinal Cancers
-Stomach Cancer
-Uterine Sarcoma
EPHB4 7q22 HTK, MYK1, TYRO11-Bladder Cancer
-Breast Cancer
-Cervical Cancer
-Colorectal Cancer
-Skin Cancer
-Thyroid Cancer
TFPI2 7q22 PP5, REF1, TFPI-2-Cancer Screening
-Cervical Cancer
-Colorectal Cancer
-Pancreatic Cancer
-Prostate Cancer
-Stomach Cancer
-Vulvar Cancer
COL1A2 7q22.1 OI4-Liver Cancer
-Stomach Cancer
MUC17 7q22.1 MUC3-Colorectal Cancer
-Pancreatic Cancer
COPS6 7q22.1 CSN6, MOV34-34KD-Esophageal Cancer
-Stomach Cancer
CUX1 7q22.1 CDP, CUX, p75, CASP, CDP1, COY1, Clox, p100, p110, p200, CUTL1, GOLIM6, CDP/Cut, Cux/CDP, Nbla10317Somatic
SERPINE1 7q22.1 PAI, PAI1, PAI-1, PLANH1-Breast Cancer
-Liver Cancer
-Uterine Sarcoma
MET 7q31 HGFR, AUTS9, RCCP2, c-MetSomatic-Breast Cancer
-Cervical Cancer
-Colorectal Cancer
-Esophageal Cancer
-Kidney Cancer
-Liver Cancer
-Liver Cancer, Childhood
-Lung Cancer
-Lung Cancer, Non-Small Cell
-Prostate Cancer
-Soft Tissue Sarcoma
-Stomach Cancer
ING3 7q31 Eaf4, ING2, MEAF4, p47ING3-Head and Neck Cancers
-Liver Cancer
-Melanoma
PPP1R3A 7q31.1 GM, PP1G, PPP1R3-Colorectal Cancer
-Haematological Malignancies
-Liver Cancer
-Lung Cancer
-Melanoma
-Ovarian Cancer
CAV1 7q31.1 CGL3, PPH3, BSCL3, LCCNS, VIP21, MSTP085-Breast Cancer
-Cervical Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
-Prostate Cancer
-Thyroid Cancer
WNT2 7q31.2 IRP, INT1L1-Breast Cancer
-Colorectal Cancer
-Lung Cancer
-Stomach Cancer
TES 7q31.2 TESS, TESS-2-Breast Cancer
-Prostate Cancer
-Skin Cancer
ST7 7q31.2 HELG, RAY1, SEN4, TSG7, ETS7q, FAM4A, FAM4A1-Breast Cancer
-Colorectal Cancer
-Ovarian Cancer
-Prostate Cancer
-Stomach Cancer
CFTR 7q31.2 CF, MRP7, ABC35, ABCC7, CFTR/MRP, TNR-CFTR, dJ760C5.1-Cervical Cancer
-Colorectal Cancer
-Lung Cancer
-Pancreatic Cancer
-Uterine Sarcoma
POT1 7q31.33 CMM10, HPOT1-Breast Cancer
-Chronic Lymphocytic Leukemia
-Familial Melanoma
-Parathyroid Cancer
-Stomach Cancer
-Thyroid Cancer
TRIM24 7q32-q34 PTC6, TF1A, TIF1, RNF82, TIF1A, hTIF1, TIF1ALPHASomatic-Breast Cancer
-Liver Cancer
-Prostate Cancer
HIPK2 7q32-q34 PRO0593-Astrocytoma, Childhood
-Breast Cancer
-Thyroid Cancer
FLNC 7q32-q35 ABPA, ABPL, FLN2, MFM5, MPD4, ABP-280, ABP280A-Breast Cancer
-Melanoma
-Prostate Cancer
MEST 7q32 PEG1-Cervical Cancer
-Kidney Cancer
-Lung Cancer
-Uterine Sarcoma
-Wilms Tumour
CALU 7q32.1 -Breast Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
SMO 7q32.3 Gx, SMOH, FZD11Somatic-Medulloblastoma
-Cervical Cancer
-Pancreatic Cancer
-Basal Cell Carcinoma (BCC) - Skin
-Stomach Cancer
AKR1B10 7q33 HIS, HSI, ARL1, ARL-1, ALDRLn, AKR1B11, AKR1B12-Liver Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
-Stomach Cancer
EPHB6 7q33-q35 HEP-Brain Tumours, Childhood
-Breast Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
-Neuroblastoma
CREB3L2 7q34 BBF2H7Somatic
Translocation
-Skin Cancer
-Soft Tissue Sarcoma
EPHA1 7q34 EPH, EPHT, EPHT1-Breast Cancer
-Colorectal Cancer
CASP2 7q34-q35 ICH1, NEDD2, CASP-2, NEDD-2, PPP1R57-Breast Cancer
-Leukaemia
-Lung Cancer
-Ovarian Cancer
PRSS1 7q34 TRP1, TRY1, TRY4, TRYP1-Liver Cancer
-Pancreatic Cancer
BRAF 7q34 NS7, BRAF1, RAFB1, B-RAF1Somatic-Colorectal Cancer
-Lung Cancer
-Melanoma
-Non-Hodgkin Lymphoma
-Thyroid Cancer
TRB 7q34 TCRB, TRB@Somatic
Translocation
-Acute Lymphocytic Leukaemia (ALL)
-Retinoblastoma
-Thyroid Cancer
KIAA1549 7q34 Somatic-Astrocytoma, Childhood
-Brain Stem Glioma, Childhood
-Brain Tumours, Childhood
EZH2 7q35-q36 WVS, ENX1, EZH1, KMT6, WVS2, ENX-1, EZH2b, KMT6ASomatic-Bladder Cancer
-Breast Cancer
-Cervical Cancer
-Soft Tissue Sarcoma
-Stomach Cancer
ARHGEF5 7q35 P60, TIM, GEF5, TIM1-Breast Cancer
-Endometrial Cancer
-Lung Cancer, Non-Small Cell
MNX1 7q36 HB9, HLXB9, SCRA1, HOXHB9Somatic-Acute Lymphocytic Leukaemia (ALL)
-Acute Myeloid Leukaemia
-Leukaemia
-Wilms Tumour
NOS3 7q36 eNOS, ECNOS-Bladder Cancer
-Breast Cancer
-Prostate Cancer
-Stomach Cancer
-Vulvar Cancer
CDK5 7q36 PSSALRE-Lung Cancer
-Neuroblastoma
RHEB 7q36 RHEB2-Bladder Cancer
CUL1 7q36.1 -Breast Cancer
-Prostate Cancer
KMT2C 7q36.1 HALR, MLL3Somatic-Esophageal Cancer
XRCC2 7q36.1 -Breast Cancer
-Colorectal Cancer
-Esophageal Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
-Ovarian Cancer
VIPR2 7q36.3 VPAC2, VPAC2R, VIP-R-2, VPCAP2R, PACAP-R3, DUP7q36.3, PACAP-R-3, C16DUPq36.3-Lung Cancer
-Neurofibromatosis
-Prostate Cancer

Structural Abnormalities

Selected list of common recurrent structural abnormalities - Chromosome 7:

Abnormality Type Gene(s)
ETV1 translocations in Prostate CancerTranslocationETV1 (7p21.3)TMPRSS2 (21q22.3)
t(7;22)(p22;q12) EWS-ETV1 Translocation in Ewing's SarcomaTranslocationETV1 (7p21.3)EWSR1 (22q12.2)
t(7;16)(q33;p11) FUS-CREB3L2 in Low-grade fibromyxoid sarcomaTranslocationCREB3L2 (7q34)FUS (16p11.2)
t(7;19)(q35;p13) in T-cell Acute Lymphoblastic LeukemiaTranslocationTRB (7q34)LYL1 (19p13.2)
t(7;9)(q34;q34) in T-Cell Acute Lymphoblastic LeukaemiaTranslocationTRB (7q34)NOTCH1 (9q34.3)
t(7;11)(p15;p15) in Acute Myelogenous LeukaemiaTranslocationHOXA9 (7p15.2)NUP98 (11p15.5)

This is a highly selective list aiming to capture structural abnormalies which are frequesnt and/or significant in relation to diagnosis, prognosis, and/or characterising specific cancers. For a much more extensive list see the Mitelman Database of Chromosome Aberrations and Gene Fusions in Cancer.


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Cite this page: Cotterill SJ. Chromosome 7, Cancer Genetics Web: http://www.cancerindex.org/geneweb/clinkc07.htm Accessed: date

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