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  Chromosome 7

Genes Linked with Cancer

How to use this data table Click on the gene name for detailed information. Type in the Search box e.g. 'germline' or 'Breast Cancer' to search within Chromosome 7; or Sort by clicking on a column heading e.g. 'Gene'.

Gene Location Aliases Abnormalities Implicated in
EGFR 7p12 ERBB, HER1, mENA, ERBB1, PIG61Germline & Somatic-Synovial Sarcoma
IKZF1 7p12.2 IK1, LYF1, hIk-1, IKAROS, PRO0758, ZNFN1A1, Hs.54452Somatic
GLI3 7p13 PHS, ACLS, GCPS, PAPA, PAPB, PAP-A, PAPA1, PPDIV, GLI3FL, GLI3-190
IGFBP3 7p13-p12 IBP3, BP-53
TRG 7p14 TCRG, TRG@
AMPH 7p14-p13 AMPH1-Breast Cancer
SEPT7 7p14.2 CDC3, CDC10, SEPT7A, NBLA02942
HNRNPA2B1 7p15 RNPA2, HNRPA2, HNRPB1, SNRPB1, HNRNPA2, HNRNPB1, IBMPFD2, HNRPA2B1Somatic
RALA 7p15-p13 RAL
HOXA9 7p15.2 HOX1, ABD-B, HOX1G, HOX1.7Somatic
Translocation
-Acute Myeloid Leukaemia
-Chronic Myelogenous Leukemia
HOXA13 7p15.2 HOX1, HOX1JSomatic
JAZF1 7p15.2-p15.1 TIP27, ZNF802Somatic
HOXA11 7p15.2 HOX1, HOX1ISomatic
IL6 7p21 HGF, HSF, BSF2, IL-6, IFNB2
TWIST1 7p21.2 CRS, SCS, ACS3, CRS1, BPES2, BPES3, TWIST, bHLHa38-Bowel Cancer
-Breast Cancer
-Lung Cancer
-Oral Cavity Cancer
ETV1 7p21.3 ER81Somatic
Translocation
-Ewing's Sarcoma
-Gastrointestinal Stromal Tumors
-Melanoma
-Prostate Cancer
CARD11 7p22 PPBL, BENTA, BIMP3, IMD11, CARMA1Somatic
PDGFA 7p22 PDGF1, PDGF-A-Brain Stem Glioma, Childhood
-Uterine Sarcoma
PMS2 7p22.2 PMSL2, HNPCC4, PMS2CLGermline
SBDS 7q11.21 SDS, SWDS, CGI-97Germline
HSPB1 7q11.23 CMT2F, HMN2B, HSP27, HSP28, Hsp25, SRP27, HS.76067, HEL-S-102
ELN 7q11.23 WS, WBS, SVASSomatic
HIP1 7q11.23 HIP-I, ILWEQSomatic
CDK6 7q21-q22 PLSTIRESomatic
AKAP9 7q21-q22 LQT11, PRKA9, AKAP-9, CG-NAP, YOTIAO, AKAP350, AKAP450, PPP1R45, HYPERION, MU-RMS-40.16ASomatic
HGF 7q21.1 SF, HGFB, HPTA, F-TCF, DFNB39
ABCB4 7q21.1 GBD1, ICP3, MDR2, MDR3, PGY3, ABC21, MDR2/3, PFIC-3
CYP3A4 7q21.1 HLP, CP33, CP34, CYP3A, NF-25, CYP3A3, P450C3, CYPIIIA3, CYPIIIA4, P450PCN1
ABCB1 7q21.12 CLCS, MDR1, P-GP, PGY1, ABC20, CD243, GP170
STEAP2 7q21.13 STMP, IPCA1, PUMPCn, STAMP1, PCANAP1
MUC3A 7q22 MUC3, MUC-3A
MUC17 7q22.1 MUC3
CUX1 7q22.1 CDP, CUX, p75, CASP, CDP1, COY1, Clox, p100, p110, p200, CUTL1, GOLIM6, CDP/Cut, Cux/CDP, Nbla10317Somatic
MET 7q31 HGFR, AUTS9, RCCP2, c-MetSomatic
PPP1R3A 7q31.1 GM, PP1G, PPP1R3
CAV1 7q31.1 CGL3, PPH3, BSCL3, VIP21, MSTP085
TRIM24 7q32-q34 PTC6, TF1A, TIF1, RNF82, TIF1A, hTIF1, TIF1ALPHASomatic
SMO 7q32.3 Gx, SMOH, FZD11Somatic
KIAA1549 7q34 Somatic
BRAF 7q34 NS7, BRAF1, RAFB1, B-RAF1Somatic-Bowel Cancer
-Lung Cancer
-Melanoma
-Non-Hodgkin Lymphoma
-Thyroid Cancer
TRB 7q34 TCRB, TRB@Somatic
Translocation
-Acute Lymphocytic Leukaemia (ALL) - adult
EPHA1 7q34 EPH, EPHT, EPHT1
CREB3L2 7q34 BBF2H7Somatic
Translocation
-Soft Tissue Sarcoma
ARHGEF5 7q35 P60, TIM, GEF5, TIM1
EZH2 7q35-q36 WVS, ENX1, EZH1, KMT6, WVS2, ENX-1, EZH2b, KMT6ASomatic
MNX1 7q36 HB9, HLXB9, SCRA1, HOXHB9Somatic
KMT2C 7q36.1 HALR, MLL3Somatic
VIPR2 7q36.3 VPAC2, VPAC2R, VIP-R-2, VPCAP2R, PACAP-R3, DUP7q36.3, PACAP-R-3, C16DUPq36.3

Structural Abnormalities

Selected list of common recurrent structural abnormalities - Chromosome 7:

Abnormality Type Gene(s)
ETV1 translocations in Prostate CancerTranslocationETV1 (7p21.3)TMPRSS2 (21q22.3)
t(7;22)(p22;q12) EWS-ETV1 Translocation in Ewing's SarcomaTranslocationETV1 (7p21.3)EWSR1 (22q12.2)
t(7;16)(q33;p11) FUS-CREB3L2 in Low-grade fibromyxoid sarcomaTranslocationCREB3L2 (7q34)FUS (16p11.2)
t(7;19)(q35;p13) in T-cell Acute Lymphoblastic LeukemiaTranslocationTRB (7q34)LYL1 (19p13.2)
t(7;9)(q34;q34) in T-Cell Acute Lymphoblastic LeukaemiaTranslocationTRB (7q34)NOTCH1 (9q34.3)
t(7;11)(p15;p15) in Acute Myelogenous LeukaemiaTranslocationHOXA9 (7p15.2)NUP98 (11p15.5)

This is a highly selective list aiming to capture structural abnormalies which are frequesnt and/or significant in relation to diagnosis, prognosis, and/or characterising specific cancers. For a much more extensive list see the Mitelman Database of Chromosome Aberrations and Gene Fusions in Cancer.


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