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MeSH term: Tracheal Neoplasms
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c-Myb Overexpression in Cytology Smears of Tracheobronchial and Pulmonary Adenoid Cystic Carcinomas.
Acta Cytol. 2017; 61(1):77-83 [PubMed] Related Publications
STUDY DESIGN: Cases of AdCC of the LRT diagnosed on cytology or histology were retrieved from our institutional archives. c-Myb expression was analyzed on immunocytochemistry/immunohistochemistry (ICC/IHC) and was correlated with clinicopathological parameters.
RESULTS: Twenty-three samples of AdCC originating from the LRT were included in the study. Four cases were diagnosed on cytology, 3 of which had corresponding histology specimens. The remaining 19 cases had either biopsy or resection. Most of the patients presented with endobronchial mass. The mean age was 49.4 years and a male predominance was seen. ICC and IHC for c-Myb showed positivity in 75 and 59% of the cases, respectively. Western blot was used to validate IHC results.
CONCLUSION: AdCC of the LRT is rare and hence poses diagnostic difficulty. Cytology smears can be utilized for c-Myb ICC. The presence of c-Myb immunopositivity in most cases may possibly make Myb a diagnostic biomarker and a therapeutic target for personalized treatment.
Primary mucoepidermoid carcinoma at the carina of trachea presenting with wheezing in an asthmatic child mimicking an attack of asthma: A case report.
Medicine (Baltimore). 2016; 95(44):e5292 [PubMed] Related Publications
CLINICAL FINDINGS: This report describes a 12-year-old boy with a previous history of frequent asthma attacks and experienced responses to antiasthma treatment. He was admitted to the hospital due to persistent wheezing and progressive dyspnea. Hyperinflation in the bilateral lungs was detected on chest x-ray, but without other significant findings. Chest computed tomography revealed a mass at the carina. Tracheal mucoepidermoid carcinoma was diagnosed by histopathological assessment.
CONCLUSION: Despite the rarity of tracheal tumors, chest computed tomography scans should be performed in the first place for children presenting persistent wheezing and having poor response to antiasthma treatment to rule out the other alternative diagnosis. Coexistence of other diseases such as tracheal tumor in asthmatic patients should be considered.
Young man with dyspnoea for 6 months; presenting with subacute tracheal obstruction due to leiomyoma.
BMJ Case Rep. 2016; 2016 [PubMed] Related Publications
Liquid-based sputum cytology of bicomponent mucin-producing adenocarcinoma of the trachea with histologic comparison.
Diagn Cytopathol. 2016; 44(12):1120-1124 [PubMed] Related Publications
Spindle cell sarcomatoid carcinoma of the trachea: first case report of surgical resection.
J Cardiothorac Surg. 2016; 11(1):128 [PubMed] Free Access to Full Article Related Publications
CASE PRESENTATION: We present a 75-year-old male, having progressive dyspnea and cough, with a spindle cell sarcomatoid carcinoma tumor visualized on chest computed tomography scan and confirmed with biopsy.
CONCLUSIONS: Due to its low incidence, knowledge of treatment methods, prognostic factors, and etiology is limited thus approaches to eradication have widely varied. We are reporting the second published case of spindle cell sarcomatoid carcinoma of the trachea and the first reported successful outcome of definitive treatment with tracheal resection.
Management of tracheal chondrosarcoma almost completely obstructing the airway: a case report.
J Cardiothorac Surg. 2016; 11(1):101 [PubMed] Free Access to Full Article Related Publications
CASE PRESENTATION: We present the case of a 79-year old Caucasian man with long-lasting wheezing misdiagnosed as asthma and affected by a tracheal chondrosarcoma almost completely obstructing the airway. Videobronchoscopy and imaging investigations revealed a well-circumscribed mass arising from the cartilaginous rings of the cervical trachea with a posterior residual respiratory space of about 1 mm. Because of the mobility and flaccidity of the uninvolved pars membranacea, the tiny respiratory space slightly expanded during inspiration and expiration allowing the patient to be treated without an essential emergency procedure. Standard tracheal intubation was impossible. Rigid bronchoscopy enabled placement of a small tracheal tube distally to the tumor. Successful cervical tracheal resection and reconstruction was then performed, achieving complete tumor excision. Histologically, the mass was characterized as a low-grade tracheal chondrosarcoma. Videobronchoscopy performed 9 months after surgery showed a wide, well healed tracheal anastomosis. Ten months after surgery, the patient is alive and disease free.
CONCLUSION: Complete surgical resection is the treatment of choice for tracheal chondrosarcoma. Rigid bronchoscopy is an essential tool for diagnostic and therapeutic purposes. It allows the palliative maneuvers for obstruction relief but also, in resectable patients, the intraoperative safe and straightforward management of the obstructed airway.
Anesthesia airway management in a patient with upper tracheal tumor.
J Clin Anesth. 2016; 32:134-6 [PubMed] Related Publications
Unusual Granular Cell Tumor of the Trachea Coexisting With Papillary Thyroid Carcinoma and Masquerading as Tracheal Invasion of Recurred Thyroid Carcinoma: A Case Report.
Medicine (Baltimore). 2016; 95(18):e3547 [PubMed] Free Access to Full Article Related Publications
18F-FDG PET/CT and Contrast-Enhanced CT of Primary Malignant Tracheal Tumor.
Clin Nucl Med. 2016; 41(8):595-605 [PubMed] Related Publications
MATERIALS AND METHODS: We retrospectively reviewed the F-FDG PET/CT and CE-CT findings of 13 patients with histologically confirmed primary tumors who had undergone PET/CT and CE-CT in the same session. The following parameters were recorded: SUVmax; SUVmax lesion/background; location, size and attenuation of the mass; mediastinal invasion; and the presence of metastases. Clinical data, bronchial endoscopy results, and surgical and histopathological findings were also collected.
RESULTS: Tracheal soft tissue lesions with increased F-FDG uptake were observed in all patients. Five squamous cell carcinomas, 5 adenoid cystic carcinomas, 2 adenocarcinomas, and 1 mucosa-associated lymphoid tumor were histopathologically observed. The maximum SUV of the malignant tracheal tumors ranged from 2.7 to 20.5 (mean ± SD, 6.8 ± 4.8; median, 5.7). All SUVmax lesion values were greater than 2.5. Homogeneous enhancement was observed in all lesions, with three exhibiting evident enhancement, nine demonstrating moderate enhancement, and one showing mild enhancement.
CONCLUSIONS: The presence of a tracheal soft tissue mass with increased F-FDG uptake is highly suggestive of a malignant tracheal tumor. F-FDG PET/CT and CE-CT can clearly demonstrate such a tumor's function and anatomical characteristics.
Primary ectopic substernal thyroid cancer with trachea relapse: a case report and opinions of management.
World J Surg Oncol. 2016; 14:94 [PubMed] Free Access to Full Article Related Publications
CASE PRESENTATION: In this report, the patient presented odynophagia and a sense of progressing swallowing obstruction. She underwent total thyroidectomy and lump resection. However, she refused to use postoperative radioactive iodine or take adjuvant external-beam radiotherapy, except for thyroid hormone replacement therapy. Tracheal relapse was observed after 6 months. Tracheal stent was used to reconstruct the airway twice.
CONCLUSIONS: Trachea invasion might be a worse independent predictor of prognosis than any others and should be given particular attention. Furthermore, tracheal stent might be a palliative option for patients with tracheal relapse.
Tracheal Glomangioleiomyoma Treated by Multimodal Interventional Bronchoscopy.
Ann Thorac Surg. 2016; 101(4):1591-4 [PubMed] Related Publications
Primary Squamous Cell Carcinoma of Trachea Arising 4 Years After Radioiodine Treatment of Papillary Carcinoma of Thyroid.
Clin Nucl Med. 2016; 41(5):e259-60 [PubMed] Related Publications
Childhood and adolescent tracheobronchial mucoepidermoid carcinoma (MEC): a case-series and review of the literature.
Pediatr Surg Int. 2016; 32(4):417-24 [PubMed] Related Publications
Autologous tracheal replacement for cancer.
Chin Clin Oncol. 2015; 4(4):46 [PubMed] Related Publications
A rare cause of recurrent wheeze and seizures.
BMJ Case Rep. 2015; 2015 [PubMed] Related Publications
Minimally Invasive Tracheal Resection: Cervical Approach Plus Video-Assisted Thoracoscopic Surgery.
Ann Thorac Surg. 2015; 100(6):2336-9 [PubMed] Related Publications
Mucoepidermoid Carcinoma of the Tracheobronchial Tree.
Methodist Debakey Cardiovasc J. 2015 Jul-Sep; 11(3):192-4 [PubMed] Free Access to Full Article Related Publications
Case Reports on the Differentiation of Malignant and Benign Intratracheal Lesions by 18F-FDG PET/CT.
Medicine (Baltimore). 2015; 94(44):e1704 [PubMed] Free Access to Full Article Related Publications
Office-Based Subglottic Evaluation in Children With Risk of Subglottic Hemangioma.
Ann Otol Rhinol Laryngol. 2016; 125(4):273-6 [PubMed] Related Publications
RESULTS: Since 2003, 5 children with IH of the V3 cutaneous distribution and 3 children with PHACE syndrome underwent OLAE. Average age of presentation was 2.75 months. Two children had stridor at initial evaluation, and 1 child had subglottic hemangioma. This child was evaluated serially with OLAE to monitor disease progression and treatment response. A total of 10 upper tracheoscopies were performed on the 8 patients without respiratory complications.
CONCLUSION: An airway evaluation is essential to evaluate and manage this high-risk population. Typically, operative endoscopy requires general anesthesia. However, in these high-risk children, we have performed OLAE without sedation to evaluate the trachea. High-speed recording and playback is essential in this method. Our series demonstrates that awake OLAE is possible and may be a safe technique to evaluate and monitor disease progression in these high-risk patients. These patients avoided general anesthesia and delay in diagnosis and did not incur any complications during or after OLAE.
Glomus tumor of the trachea: a rare case report.
Int J Clin Exp Pathol. 2015; 8(8):9723-6 [PubMed] Free Access to Full Article Related Publications
Resected Tracheal Adenoid Cystic Carcinoma: Improvements in Outcome at a Single Institution.
Ann Thorac Surg. 2016; 101(1):294-300 [PubMed] Related Publications
METHODS: This retrospective review included patients with localized primary tracheal adenoid cystic carcinoma treated surgically at our institution between January 1995 and December 2014. Patients were classified according to the timing of first operation: "early years" operation was performed between January 1995 and December 2002, and subsequent "recent years" operation was associated with improved management and a focus on early diagnosis.
RESULTS: The proportion of patients with tracheal malignancy who underwent operation for adenoid cystic carcinoma increased with time. Patients in the recent group were significantly younger than those in the early group at diagnosis (49.3 ± 7.8 years versus 45.7 ± 9.4 years; p = 0.042), and the resected tumor size and tracheal lengths tended to be smaller (28.2 ± 7.6 mm versus 30.3 ± 7.0 mm; p = 0.161) and shorter (32.1 ± 7.7 mm versus 34.4 ± 6.7 mm; p = 0.123). The use of postoperative radiotherapy in patients with R1 resection was also managed more effectively in the recent group compared with the early group (90.6% versus 65.0%; p = 0.009). Five- and 10-year overall survival rates in the early and recent groups were 86.4% and 90.8%, and 31.8% and 61.2%, respectively (p = 0.084), and the corresponding 5- and 10-year disease-free survival rates were 39.7% and 75.3%, and 9.9% and 21.2%, respectively (p = 0.025).
CONCLUSIONS: There have been improved outcomes of adenoid cystic carcinomas. Early diagnosis, experienced surgical treatments, and postoperative adjuvant radiotherapy for patients with positive margins may contribute to the improved survival of patients with primary tracheal adenoid cystic carcinoma.
Malignant glomus tumor of trachea: a case report with literature review.
Asian Cardiovasc Thorac Ann. 2016; 24(1):104-6 [PubMed] Related Publications
Primary tracheal and bronchial lymphoma displayed on 18F-FDG PET/CT imaging.
Clin Nucl Med. 2015; 40(12):965-6 [PubMed] Related Publications
Diagnostic Value of Multidetector CT and Its Multiplanar Reformation, Volume Rendering and Virtual Bronchoscopy Postprocessing Techniques for Primary Trachea and Main Bronchus Tumors.
PLoS One. 2015; 10(9):e0137329 [PubMed] Free Access to Full Article Related Publications
METHODS: Detection results of 31 primary trachea and main bronchus tumors with MDCT and its MPR, VR and VB postprocessing techniques, were analyzed retrospectively with regard to tumor locations, tumor morphologies, extramural invasions of tumors, longitudinal involvements of tumors, morphologies and extents of luminal stenoses, distances between main bronchus tumors and trachea carinae, and internal features of tumors. The detection results were compared with that of surgery and pathology.
RESULTS: Detection results with MDCT and its MPR, VR and VB were consistent with that of surgery and pathology, included tumor locations (tracheae, n = 19; right main bronchi, n = 6; left main bronchi, n = 6), tumor morphologies (endoluminal nodes with narrow bases, n = 2; endoluminal nodes with wide bases, n = 13; both intraluminal and extraluminal masses, n = 16), extramural invasions of tumors (brokethrough only serous membrane, n = 1; 4.0 mm-56.0 mm, n = 14; no clear border with right atelectasis, n = 1), longitudinal involvements of tumors (3.0 mm, n = 1; 5.0 mm-68.0 mm, n = 29; whole right main bronchus wall and trachea carina, n = 1), morphologies of luminal stenoses (irregular, n = 26; circular, n = 3; eccentric, n = 1; conical, n = 1) and extents (mild, n = 5; moderate, n = 7; severe, n = 19), distances between main bronchus tumors and trachea carinae (16.0 mm, n = 1; invaded trachea carina, n = 1; >20.0 mm, n = 10), and internal features of tumors (fairly homogeneous densities with rather obvious enhancements, n = 26; homogeneous density with obvious enhancement, n = 1; homogeneous density without obvious enhancement, n = 1; not enough homogeneous density with obvious enhancement, n = 1; punctate calcification with obvious enhancement, n = 1; low density without obvious enhancement, n = 1).
CONCLUSION: MDCT and its MPR, VR and VB images have respective advantages and disadvantages. Their combination could complement to each other to accurately detect locations, natures (benignancy, malignancy or low malignancy), and quantities (extramural invasions, longitudinal involvements, extents of luminal stenoses, distances between main bronchus tumors and trachea carinae) of primary trachea and main bronchus tumors with crucial information for surgical treatment, are highly useful diagnostic methods for primary trachea and main bronchus tumors.
Endoscopic treatment of primary benign central airway tumors: Results from a large consecutive case series and decision making flow chart to address bronchoscopic excision.
Eur J Surg Oncol. 2015; 41(10):1437-42 [PubMed] Related Publications
OBJECTIVES: report the twelve-years endoscopic experience in Rome, Italy. Fifty-seven benign tracheo-bronchial tumors were diagnosed and 130 tracheo-bronchial resections by rigid bronchoscopy performed.
METHODS: we identified histotypes associated with higher recurrence rate and assessed their relationship with gender, age and tracheo-bronchial location. We provided data on safety and complications and suggested a decision making flow chart to address the patients to endoscopic resection.
RESULTS: complete eradication after a single procedure without recurrence at 2 years was obtained in 63.1% of cases (36/57). Need of a second intervention within few months but no further recurrence at follow up was seen in a further 8.8% (5/57). Histotypes associated with recurrence were papillomas and inflammatory polyp. Seven patients (12.3%) were addressed to surgery because of multiple recurrence. Ten patients (17.5%) were lost at follow up. In case of recurrence, the bronchial biopsy was always repeated and no malignant transformation was observed. No major complications, pneumothorax or pneumomediastinum occurred.
CONCLUSIONS: endoscopic treatment of benign tracheo bronchial tumors is safe and effective, provided that the procedure is carefully and systematically planned. The rate of eradication is satisfactory and the incidence of complications negligible. This will encourage this approach as first line treatment especially in patients, frequently elderly people, having increased surgical risk due to concomitant respiratory failure or major comorbidities.
Primary small cell cancer of cervical trachea: a case report and literature review.
Int J Clin Exp Pathol. 2015; 8(6):7488-93 [PubMed] Free Access to Full Article Related Publications
CASE REPORT: we report a case of cervical tracheal small cell cancer. A 67-year-old male presented with over 2-month history of cough and dyspnea. CT and MRI revealed a 1.0 cm × 2.5 cm intraluminal, irregular soft tissue mass in the upper trachea, approximately 2.5 cm below the glottis. A bronchoscopic examination disclosed a large tumor in the cervical trachea and the lesion occupied more than 60% of the tracheal lumen. Cytological examination suggested some poorly differentiated carcinoma cells. The patient received concurrent chemoradiotherapy and did not perform surgery. One week after CCR, the patient occurred difficulty in breath and tracheal stent was implanted. The symptom was improved markedly. Four days after implant of tracheal stent, the patient presented irritable cough and hemoptysis. The amount of bleeding was about 300 ml. The hemorrhage stopped by treatment of vasoconstrictor and fresh plasma. However, two days later, hemoptysis was continuing even if treatment of vasoconstrictor and fresh plasma. The patient and relatives waived the further therapies. The patient died of massive hemoptysis one week out of hospital.
CONCLUSIONS: The tracheal small cell cancer is rare. The optimal treatment is unclear. In general, the strategy is introduced concurrent chemoradiotherapy following as small cell lung cancer. In cervical trachea, we suggest that surgical resection should be performed followed by postoperative adjuvant therapy.
Asymptomatic tracheal MALT lymphoma discovered on spirometric findings presenting with elevated respiratory resistance.
BMC Res Notes. 2015; 8:223 [PubMed] Free Access to Full Article Related Publications
CASE PRESENTATION: We here described a 64-year-old asymptomatic female with tracheal mucosa-associated lymphoid tissue lymphoma discovered on spirometric findings during a complete physical examination. The plateau of forced expiratory flow was consistent with CAO. A decreased peak expiratory flow rate was noted at least 3 years before the diagnosis, and was attributed to an insufficient effort by the patient. Impulse oscillometric measurements, which were taken during quiet breathing and were effort-independent, suggested elevated respiratory resistance. These abnormalities completely disappeared after radiation therapy.
CONCLUSION: The addition of impulse oscillometry to spirometry may be useful for screening CAO in routine health examinations.
Leiomyoma of the Trachea: a case report.
J Cardiothorac Surg. 2015; 10:78 [PubMed] Free Access to Full Article Related Publications
Treatment of tracheal mucoepidermoid carcinoma by argon plasma coagulation during pregnancy.
Int Surg. 2015; 100(5):927-9 [PubMed] Free Access to Full Article Related Publications
Bronchoplastic closure as an alternative approach for tracheal reconstruction following resection of a massive tracheal tumour.
Interact Cardiovasc Thorac Surg. 2015; 21(2):263-5 [PubMed] Related Publications