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HRAS; v-Ha-ras Harvey rat sarcoma viral oncogene homolog (11p15.5)
HRAS Menu

    Summary Information - HRAS
    Gene Database Entries for HRAS
    Other HRAS Related Resources
    Ras and Cancer
       - HRAS Transformation Signaling Pathway
       - RAS and Apoptosis
    Ras Inhibitors in Gene Therapy (Experimental)
    HRAS Minisatellite Alleles and Cancer Susceptibility
    HRAS Mutations in Bladder Cancer
       - HRAS Minisatellite Alleles and Breast Cancer Risk
       - HRAS Minisatellite Alleles and Ovarian Cancer Risk
       - HRAS Minisatellite Alleles and Lung Cancer Risk
    HRAS Mutations in Colorectal Cancer
       - HRAS Minisatellite Alleles and Colorectal Cancer Risk
    Feedback / suggest a new topic for HRAS


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  Summary Information

HRAS; v-Ha-ras Harvey rat sarcoma viral oncogene homolog

Location: 11p15.5

Overview: HRAS (sometimes just reffered to as Ras) is an oncogene found on chromosome 11. In normal cells it acts as a switch to signal cell growth when receptors on the cell surface are stimulated by hormones or other agents. If HRAS is "switched on" then it signals for the cell to grow, if it is "switched off" then the cell does not grow. HRAS is mutated in approximately one third of human cancers causing it to be permanently "switched on". Such a mutation may not in itself be enough to cause a cell to become cancerous, mutations in other genes may also be required. HRAS is part of the RAS family of oncogenes, which also includes KRAS and NRAS.

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  Gene Database Entries for HRAS

OMIM
GeneCard (Weizmann Institute)
Atlas of Genetics and Cytogenetics in Oncology and Haematology
Tumor Gene Database
Swiss-Prot
Locus Link
UniGene
GenAtlas
GDB
Nomenclature (search for HRAS)

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  Other Related Resources


HRAS (National Center for Biotechnology Information) an overview of the HRAS oncogene with links to other gene databases.

  • Medline Search: HRAS (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]
    Search Medline for related articles (PubMed)
  • Medline Search: cancer AND gene AND HRAS[TI] (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]
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  •   Ras and Cancer

  • Shields JM, et al. Understanding Ras: 'it ain't over 'til it's over'. [Review] Trends Cell Biol 2000 Apr;10(4):147-54    Related articles (PubMed)

  • Beaupre DM, Kurzrock R RAS inhibitors in hematologic cancers: biologic considerations and clinical applications. Invest New Drugs 1999;17(2):137-43    Related articles (PubMed)

  • Medline Search: cancer AND (ras OR hras) (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

    Related Resources
    Resources by Disease Type

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  •   HRAS Transformation Signaling Pathway

  • Yamamoto T, et al. Ras-induced transformation and signaling pathway. [Review] J Biochem (Tokyo) 1999 Nov;126(5):799-803    Related articles

  • Medline Search: (Ras[TI] OR ras[TI] OR hras[TI]) AND cancer AND tranformation signalling (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

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  •   RAS and Apoptosis

  • Downward J Ras signalling and apoptosis. Curr Opin Genet Dev 1998 Feb;8(1):49-54    Related articles (PubMed)

  • Medline Search: (Ras[TI] OR ras[TI] OR hras[TI]) AND cancer AND apoptosis (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

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  •   Ras Inhibitors in Gene Therapy (Experimental)

  • Scharovsky OG, et al. Inhibition of ras Oncogene: A Novel Approach to Antineoplastic Therapy. J Biomed Sci 2000 Jul;7(4):292-298    Related articles (PubMed)

  • Hill BT, et al. Inhibition of RAS-targeted prenylation: protein farnesyl transferase inhibitors revisited. [Review] Crit Rev Oncol Hematol 2000 Jan;33(1):7-23    Related articles (PubMed)

  • Medline Search: (Ras[TI] OR ras[TI] OR hras[TI]) AND cancer AND gene therapy (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

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  •   HRAS Minisatellite Alleles and Cancer Susceptibility

  • Krontiris TG, et al. An association between the risk of cancer and mutations in the HRAS1 minisatellite locus. N Engl J Med 1993 Aug 19;329(8):517-23    Related articles (PubMed)

  • Conway K, et al. Internal sequence variations in the Ha-ras variable number tandem repeat rare and common alleles identified by minisatellite variant repeat polymerase chain reaction.    Related articles (PubMed)

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  •   HRAS Mutations in Bladder Cancer

  • Cattan N, et al. Screening of human bladder carcinomas for the presence of Ha-ras codon 12 mutation. Oncol Rep 2000 May-Jun;7(3):497-500    Related articles (PubMed)

  • Burchill SA, et al. Frequency of H-ras mutations in human bladder cancer detected by direct sequencing. Br J Urol 1994 May;73(5):516-21    Related articles (PubMed)

  • Medline Search: (Ras[TI] ras[TI] OR hras[TI]) AND bladder[TI] AND cancer (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

    Related Resources
    Bladder Ca. Genetics
    Bladder Ca. : Clinical and Epidemiological Information

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  •   HRAS Minisatellite Alleles and Breast Cancer Risk

  • Gosse-Brun S, et al. Specific H-Ras minisatellite alleles in breast cancer susceptibility. Anticancer Res 1999 Nov-Dec;19(6B):5191-6    Related articles (PubMed)

  • Firgaira FA, et al. HRAS1 rare minisatellite alleles and breast cancer in Australian women under age forty years. J Natl Cancer Inst 1999 Dec 15;91(24):2107-11    Related articles (PubMed)

  • Ding S, et al. Distinct mutation patterns of breast cancer-associated alleles of the HRAS1 minisatellite locus. Hum Mol Genet 1999 Mar;8(3):515-21    Related articles (PubMed)

    Related Resources
    Breast Cancer Genetics
    Breast Cancer : Clinical and Epidemiological Information

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  •   HRAS Minisatellite Alleles and Ovarian Cancer Risk

  • Weitzel JN, et al. The HRAS1 minisatellite locus and risk of ovarian cancer. Cancer Res 2000 Jan 15;60(2):259-61    Related articles (PubMed)

  • Phelan CM, et al. Ovarian cancer risk in BRCA1 carriers is modified by the HRAS1 variable number of tandem repeat (VNTR) locus. Nat Genet 1996 Mar;12(3):309-11    Related articles (PubMed)

    Related Resources
    Ovarian Ca. Genetics
    Ovarian Ca. : Clinical and Epidemiological Information

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  •   HRAS Minisatellite Alleles and Lung Cancer Risk

  • Lindstedt BA, et al. Hras1 VNTR alleles as susceptibility markers for lung cancer: relationship to microsatellite instability in tumors. Lindstedt BA, et al.    Related articles (PubMed)

  • Rosell R, et al. Genetic susceptibility associated with rare HRAS1 variable number of tandem repeats alleles in Spanish non-small cell lung cancer patients. Rosell R, et al.    Related articles (PubMed)

    Related Resources
    Lung Cancer Genetics
    Lung Cancer : Clinical and Epidemiological Information

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  •   HRAS Mutations in Colorectal Cancer

  • Thomas RJ, et al. Frequency and clinico-pathological associations of ras mutations in colorectal cancer in the Victorian population. Aust N Z J Surg 1997 May;67(5):233-8    Related articles (PubMed)

    Related Resources
    ColoRectal Cancers Genetics
    ColoRectal Cancers : Clinical and Epidemiological Information

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  •   HRAS Minisatellite Alleles and Colorectal Cancer Risk

  • Gosse-Brun S, et al. Association between H-ras minisatellite and colorectal cancer risk. Anticancer Res 1998 Jul-Aug;18(4A):2611-6    Related articles (PubMed)

    Related Resources
    ColoRectal Cancers Genetics
    ColoRectal Cancers : Clinical and Epidemiological Information

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