 Summary Information
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Location: 11pter-p13
Aliases: MDU3, HA
Overview:
CD44 is a cell surface glycoprotein involved in cell/cell and cell/matrix interactions. Overexpression of CD44 has been linked to the growth and spread of a range of different types of malignancies, particularly lymphomas. In neuroblastoma, however,
advanced tumours often have low CD44 expression.
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| Gene Database Entries for CD44
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OMIM
GeneCard (Weizmann Institute)
Genbank
Swiss-Prot
PROW protein review
Locus Link
UniGene
GenAtlas
GDB
Nomenclature (search for CD44)
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| Other Related Resources
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- Search Medline for related articles (PubMed)
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- Medline Search: cancer AND gene AND (CD44[TI] OR MDU3[TI] OR HA[TI]) (PubMed)
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| CD44 and Neuroblastoma
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CD44 expression is suppresssed in many neuroblastomas, particularly in advanced / MYCN amplified tumours.
Kramer K et al. Correlation of MYCN amplification, Trk-A and CD44 expression with clinical stage in 250 patients with neuroblastoma. Eur J Cancer 1997;33:2098-100 Related articles (PubMed)
Gross N, et al. Absence of functional CD44 hyaluronan receptor on human NMYC-amplified neuroblastoma cells. Cancer Res 1997; 57(7):1387-93 Related articles (PubMed)
Medline Search: neuroblastoma AND cd44 (PubMed)
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 MYCN
Neuroblastoma Genetics
Neuroblastoma : Clinical and Epidemiological Information
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| CD44 and Gastric Cancer
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Hsieh HF, et al. Molecular studies into the role of CD44 variants in metastasis in gastric cancer. [Review] Mol Pathol 1999 Feb;52(1):25-8 Related articles (PubMed)
Medline Search: gastric cancer AND cd44 (PubMed)
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Stomach (Gastric) Cancer Genetics
Stomach (Gastric) Cancer : Clinical and Epidemiological Information
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| CD44 and Haematological Malignancies
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Medline Search: cd44 AND (leukemia OR lymphoma OR myeloma) (PubMed)
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| CD44 and Non-Hodgkin's Lymphoma
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Elevated serum CD44 levels have been detected in patients with NHL at diagnosis and at disease progression. High CD44 levels are associated with a greater tumour burden, poor response to therapy, and to unfavorable outcome.
Ristamaki R, et al. Serum CD44 in non-Hodgkin's lymphoma. Leuk Lymphoma 1999; 33(5-6):433-40 Related articles (PubMed)
Drillenburg P, et al. CD44 expression predicts disease outcome in localized large B cell lymphoma Leukemia. 1999; 13(9):1448-55 Related articles (PubMed)
Medline Search: cd44 AND lymphoma (PubMed)
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Non-Hodgkin's Lymphoma Genetics
Non-Hodgkin's Lymphoma : Clinical and Epidemiological Information
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| CD44 and Hodgkin's Disease
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Beham-Schmid C, et al. Expression of CD44 splice variant v10 in Hodgkin's disease is associated with aggressive behaviour and high risk of relapse. J Pathol 1998; 186(4):383-9 Related articles (PubMed)
Medline Search: cd44 AND Hodgkin's Disease (PubMed)
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Hodgkin's Disease Genetics
Hodgkin's Disease : Clinical and Epidemiological Information
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| CD44 and Breast Cancer
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Herrera-Gayol A, Jothy S Adhesion proteins in the biology of breast cancer: contribution of CD44 Exp Mol Pathol 1999; 66(2):149-56 Related articles (PubMed)
Medline Search: breast cancer[TITLE] AND cd44 (PubMed)
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Breast Cancer Genetics
Breast Cancer : Clinical and Epidemiological Information
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| CD44 and Colorectal Cancer
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Furuta K, et al. CD44 expression in the stromal matrix of colorectal cancer: association with prognosis Clin Cancer Res. 1998; 4(1):21-9 Related articles (PubMed)
Yamane N, et al. Soluble CD44 variant 6 as a prognostic indicator in patients with colorectal cancer Oncology. 1999; 56(3):232-8 Related articles (PubMed)
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ColoRectal Cancers Genetics
ColoRectal Cancers : Clinical and Epidemiological Information
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| CD44 and Skin Cancer
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Ichikawa T, et al. Expression of moesin and its associated molecule CD44 in epithelial skin tumors. J Cutan Pathol 1998; 25(5):237-43 Related articles (PubMed)
Hale LP, et al. Distribution of CD44 variant isoforms in human skin: differential expression in components of benign and malignant epithelia. J Cutan Pathol 1995; 22(6):536-45 Related articles (PubMed)
Medline Search: skin cancer AND cd44 (PubMed)
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Non-Melanoma Skin Cancer Genetics
Non-Melanoma Skin Cancer : Clinical and Epidemiological Information
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| CD44 and Osteosarcoma
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Kuryu M, et al. Expression of CD44 variants in osteosarcoma. J Cancer Res Clin Oncol 1999; 125(11):646-52 Related articles (PubMed)
Medline Search: osteosarcoma AND cd44 (PubMed)
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Osteosarcoma Genetics
Osteosarcoma : Clinical and Epidemiological Information
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| CD99 Expression in Hepatocellular Carcinoma
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Endo K, Terada T Protein expression of CD44 (standard and variant isoforms) in hepatocellular carcinoma: relationships with tumor grade, clinicopathologic parameters, p53 expression, and patient survival. J Hepatol 2000;32(1):78-84 Related articles (PubMed)
Medline Search: hepatocellular carcinoma AND cd44 (PubMed)
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Hepatocelular Carcinoma Genetics
Hepatocelular Carcinoma : Clinical and Epidemiological Information
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[Home] This page created: 23/11/1999 Last revised: 29/04/2003 © Copyright 1999-
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