Cancer GeneticsWeb
www.cancer-genetics.org
Navigate
Disclaimer: This site is for educational purposes only; it can not be used in diagnosis or treatment.
CD44; CD44 antigen (homing function and Indian blood group system) (11pter-p13)
CD44 Menu

    Summary Information - CD44
    Gene Database Entries for CD44
    Other CD44 Related Resources
    CD44 and Neuroblastoma
       - CD44 and Gastric Cancer
    CD44 and Haematological Malignancies
       - CD44 and Non-Hodgkin's Lymphoma
       - CD44 and Hodgkin's Disease
    CD44 and Breast Cancer
    CD44 and Colorectal Cancer
    CD44 and Skin Cancer
    CD44 and Osteosarcoma
    CD99 Expression in Hepatocellular Carcinoma
    Feedback / suggest a new topic for CD44


 Search:
  Summary Information

CD44; CD44 antigen (homing function and Indian blood group system)

Location: 11pter-p13

Aliases: MDU3, HA

Overview: CD44 is a cell surface glycoprotein involved in cell/cell and cell/matrix interactions. Overexpression of CD44 has been linked to the growth and spread of a range of different types of malignancies, particularly lymphomas. In neuroblastoma, however, advanced tumours often have low CD44 expression.

Return to CD44 Contents
 

  Gene Database Entries for CD44

OMIM
GeneCard (Weizmann Institute)
Genbank
Swiss-Prot
PROW protein review
Locus Link
UniGene
GenAtlas
GDB
Nomenclature (search for CD44)

Return to CD44 Contents
 

  Other Related Resources

Search Medline for related articles (PubMed)
  • Medline Search: cancer AND gene AND (CD44[TI] OR MDU3[TI] OR HA[TI]) (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]
  • Return to CD44 Contents
     

      CD44 and Neuroblastoma

    CD44 expression is suppresssed in many neuroblastomas, particularly in advanced / MYCN amplified tumours.

  • Kramer K et al. Correlation of MYCN amplification, Trk-A and CD44 expression with clinical stage in 250 patients with neuroblastoma. Eur J Cancer 1997;33:2098-100    Related articles (PubMed)

  • Gross N, et al. Absence of functional CD44 hyaluronan receptor on human NMYC-amplified neuroblastoma cells. Cancer Res 1997; 57(7):1387-93    Related articles (PubMed)

  • Medline Search: neuroblastoma AND cd44 (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

    Related Resources
    MYCN
    Neuroblastoma Genetics
    Neuroblastoma : Clinical and Epidemiological Information

    Return to CD44 Contents
     

  •   CD44 and Gastric Cancer

  • Hsieh HF, et al. Molecular studies into the role of CD44 variants in metastasis in gastric cancer. [Review] Mol Pathol 1999 Feb;52(1):25-8    Related articles (PubMed)

  • Medline Search: gastric cancer AND cd44 (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

    Related Resources
    Stomach (Gastric) Cancer Genetics
    Stomach (Gastric) Cancer : Clinical and Epidemiological Information

    Return to CD44 Contents
     

  •   CD44 and Haematological Malignancies


  • Medline Search: cd44 AND (leukemia OR lymphoma OR myeloma) (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

    Return to CD44 Contents
     

  •   CD44 and Non-Hodgkin's Lymphoma

    Elevated serum CD44 levels have been detected in patients with NHL at diagnosis and at disease progression. High CD44 levels are associated with a greater tumour burden, poor response to therapy, and to unfavorable outcome.

  • Ristamaki R, et al. Serum CD44 in non-Hodgkin's lymphoma. Leuk Lymphoma 1999; 33(5-6):433-40    Related articles (PubMed)

  • Drillenburg P, et al. CD44 expression predicts disease outcome in localized large B cell lymphoma Leukemia. 1999; 13(9):1448-55    Related articles (PubMed)

  • Medline Search: cd44 AND lymphoma (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

    Related Resources
    Non-Hodgkin's Lymphoma Genetics
    Non-Hodgkin's Lymphoma : Clinical and Epidemiological Information

    Return to CD44 Contents
     

  •   CD44 and Hodgkin's Disease

  • Beham-Schmid C, et al. Expression of CD44 splice variant v10 in Hodgkin's disease is associated with aggressive behaviour and high risk of relapse. J Pathol 1998; 186(4):383-9    Related articles (PubMed)

  • Medline Search: cd44 AND Hodgkin's Disease (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

    Related Resources
    Hodgkin's Disease Genetics
    Hodgkin's Disease : Clinical and Epidemiological Information

    Return to CD44 Contents
     

  •   CD44 and Breast Cancer

  • Herrera-Gayol A, Jothy S Adhesion proteins in the biology of breast cancer: contribution of CD44 Exp Mol Pathol 1999; 66(2):149-56    Related articles (PubMed)

  • Medline Search: breast cancer[TITLE] AND cd44 (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

    Related Resources
    Breast Cancer Genetics
    Breast Cancer : Clinical and Epidemiological Information

    Return to CD44 Contents
     

  •   CD44 and Colorectal Cancer

  • Furuta K, et al. CD44 expression in the stromal matrix of colorectal cancer: association with prognosis Clin Cancer Res. 1998; 4(1):21-9    Related articles (PubMed)

  • Yamane N, et al. Soluble CD44 variant 6 as a prognostic indicator in patients with colorectal cancer Oncology. 1999; 56(3):232-8    Related articles (PubMed)

  • Medline Search: colorectal cancer AND cd44 (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

    Related Resources
    ColoRectal Cancers Genetics
    ColoRectal Cancers : Clinical and Epidemiological Information

    Return to CD44 Contents
     

  •   CD44 and Skin Cancer

  • Ichikawa T, et al. Expression of moesin and its associated molecule CD44 in epithelial skin tumors. J Cutan Pathol 1998; 25(5):237-43    Related articles (PubMed)

  • Hale LP, et al. Distribution of CD44 variant isoforms in human skin: differential expression in components of benign and malignant epithelia. J Cutan Pathol 1995; 22(6):536-45    Related articles (PubMed)

  • Medline Search: skin cancer AND cd44 (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

    Related Resources
    Non-Melanoma Skin Cancer Genetics
    Non-Melanoma Skin Cancer : Clinical and Epidemiological Information

    Return to CD44 Contents
     

  •   CD44 and Osteosarcoma

  • Kuryu M, et al. Expression of CD44 variants in osteosarcoma. J Cancer Res Clin Oncol 1999; 125(11):646-52    Related articles (PubMed)

  • Medline Search: osteosarcoma AND cd44 (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

    Related Resources
    Osteosarcoma Genetics
    Osteosarcoma : Clinical and Epidemiological Information

    Return to CD44 Contents
     

  •   CD99 Expression in Hepatocellular Carcinoma

  • Endo K, Terada T Protein expression of CD44 (standard and variant isoforms) in hepatocellular carcinoma: relationships with tumor grade, clinicopathologic parameters, p53 expression, and patient survival. J Hepatol 2000;32(1):78-84    Related articles (PubMed)

  • Medline Search: hepatocellular carcinoma AND cd44 (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

    Related Resources
    Hepatocelular Carcinoma Genetics
    Hepatocelular Carcinoma : Clinical and Epidemiological Information

    Return to CD44 Contents
     

  •  [Home]   This page created: 23/11/1999  Last revised: 29/04/2003    © Copyright 1999-