 Summary Information
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Location: 11q23-11q23
Alias: PLZF
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| Gene Database Entries for ZNF145
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OMIM
GeneCard (Weizmann Institute)
Atlas of Genetics and Cytogenetics in Oncology and Haematology
Swiss-Prot
Locus Link
UniGene
GenAtlas
GDB
Nomenclature (search for ZNF145)
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| Other Related Resources
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- Search Medline for related articles (PubMed)
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- Medline Search: cancer AND gene AND (ZNF145[TI] OR PLZF[TI]) (PubMed)
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| t(11;17)(q32;q21) RARA-PLZF translocation in APL
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He LZ, et al. Distinct interactions of PML-RARalpha and PLZF-RARalpha with co-repressors determine differential responses to RA in APL. Nat Genet 1998;18(2):126-35 Related articles (PubMed)
Koken MH, et al. Retinoic acid, but not arsenic trioxide, degrades the PLZF/RARalpha fusion protein, without inducing terminal differentiation or apoptosis, in a RA-therapy resistant t(11;17)(q23;q21) APL patient. Oncogene. 1999; 18(4):1113-8 Related articles (PubMed)
Medline Search: chromosome 11 and chromosome 17 and translocation AND acute promyelocytic leukaemia (PubMed)
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Medline Search: acute promyelocytic leukaemia (PubMed)
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- Related Resources
 RARA gene- PLZF gene
Leukaemia Genetics
Leukaemia : Clinical and Epidemiological Information
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| HERV-K cORF Protein Binds to PLFZ
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Approximately 1% of the human genome is composed of the remnants retroviruses, these are viruses insert their genes into the DNA of an infected cell and from there code and release the replicated virus. Human endogenous retroviral elements (HERVs)
are retroviral genes that have been permanently incorporated into the genome, they date back millions of years to the earliest primates and are also present in the DNA of gorillas and chimpanzees.
Some HERVs have been associated with cancer, for example some testicular cancers overexpress HERV-K proteins. Recent work (Boese et al., 2000) suggests that cORF, a proten coded by HERV-K genes may play a causal role in cancer. The cORF protein was
found to bind to PLZF, a protein which would otherwise inhibit cell growth. Mice with cells injected with the cORF gene were found to develop tumours.
Boese A, et al. Human endogenous retrovirus protein cORF supports cell transformation and associates with the promyelocytic leukemia zinc finger protein. Oncogene 2000 Sep 7;19(38):4328-4336 Related articles (PubMed)
Medline Search: cORF AND (promyelocytic leukemia zinc finger OR plfz OR znf145) (PubMed)
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[Home] This page created: 09/10/1999 Last revised: 29/04/2003 © Copyright 1999-
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