 Summary Information
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Location: 1p13.3
Aliases: GST1, MU
Overview:
GSTM1 is a glutathione S-transferase which is thought to play a role in the detoxification of metabolites of carcinogens in tobacco smoke. There is some evidence to suggest that people with common polymorphisms of these genes may have an increased
susceptibility to cancer when exposed to tobacco.
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| Gene Database Entries for GSTM1
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OMIM
GeneCard (Weizmann Institute)
Human Gene Mutation Database (Cardiff, UK)
Genbank
Swiss-Prot
Locus Link (search for GSTM1)
UniGene
GenAtlas
GDB
Nomenclature (search for GSTM1)
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| Other Related Resources
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- Search Medline for related articles (PubMed)
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- Medline Search: cancer AND gene AND (GSTM1[TI] OR GST1[TI] OR MU[TI]) (PubMed)
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| Tabacco smoke, GSTM1 and Suceptability to Lung Cancer
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There is some evidence to suggest that people with common polymorphisms of GSTM1 and other Glutathione S-transferase genes may have an increased susceptibility to lung cancer when exposed to Tobacco. In a case-control study of 136 NSCLC patients (Tang,
1998) results suggested that the effect of the GSTM1 null genotype is greatest in female smokers. Other research (Bennett, 1999) indicates that people with the GSTM1 null allele may be more suseptible to lung cancer on exposure to envoronmental tabacco smoke.
Bennett WP, et al. Environmental Tobacco Smoke, Genetic Susceptibility, and Risk of Lung Cancer in Never-Smoking Women J Natl Cancer Inst. 1999; 91(23): 2009-14 Related articles
Jourenkova-Mironova N, et al. Role of glutathione S-transferase GSTM1, GSTM3, GSTP1 and GSTT1 genotypes in modulating susceptibility to smoking-related lung cancer. Pharmacogenetics 1998; 8(6):495-502 Related articles (PubMed)
Tang DL, et al. Associations between both genetic and environmental biomarkers and lung cancer: evidence of a greater risk of lung cancer in women smokers. Carcinogenesis 1998; 19(11):1949-53 Related articles (PubMed)
Le Marchand L, et al. Associations of CYP1A1, GSTM1, and CYP2E1 polymorphisms with lung cancer suggest cell type specificities to tobacco carcinogens. Cancer Res 1998; 58(21):4858-63 Related articles (PubMed)
Medline Search: GSTM1 AND lung cancer AND tabacco (PubMed)
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- Related Resources
 Smoking, Genes, and Susceptibility to Lung Cancer- Environmental Tabacco Smoke and lung Cancer
- GSTT1 gene
- Lung Cancer - Molecular Biology
Lung Cancer Genetics
Lung Cancer : Clinical and Epidemiological Information
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| GSTM1 and Bladder Cancer
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Salagovic J, et al. Genetic polymorphism of glutathione S-transferases M1 and T1 as a risk factor in lung and bladder cancers. Neoplasma 1998; 45(5):312-7 Related articles (PubMed)
Peluso M, et al White blood cell DNA adducts, smoking, and NAT2 and GSTM1 genotypes in bladder cancer: a case-control study. Cancer Epidemiol Biomarkers Prev 1998; 7(4):341-6 Related articles (PubMed)
Golka K, et al. N-Acetyltransferase 2 (NAT2) and Glutathione S-Transferase mu (GSTM1) in Bladder-cancer Patients in a Highly Industrialized Area. Int J Occup Environ Health 1997;3(2):105-110 Related articles (PubMed)
Medline Search: GSTM1 AND bladder cancer (PubMed)
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Bladder Ca. Genetics
Bladder Ca. : Clinical and Epidemiological Information
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| GSTM1 and Childhood Leukaemia
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Krajinovic M, et al. Susceptibility to childhood acute lymphoblastic leukemia: influence of CYP1A1, CYP2D6, GSTM1, and GSTT1 genetic polymorphisms. Blood 1999; 93(5):1496-501 Related articles (PubMed)
Infante-Rivard C, et al. Risk of childhood leukemia associated with exposure to pesticides and with gene polymorphisms. Epidemiology 1999; 10(5):481-7 Related articles (PubMed)
Chen CL, et al. Higher frequency of glutathione S-transferase deletions in black children with acute lymphoblastic leukemia. Blood 1997; 89(5):1701-7 Related articles (PubMed)
Hall AG, et al. Expression of mu class glutathione S-transferase correlates with event-free survival in childhood acute lymphoblastic leukemia. Cancer Res 1994 Oct 15;54(20):5251-4 Related articles (PubMed)
Medline Search: GSTM1 AND childhood leukemia (PubMed)
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Childhood Leukaemia Genetics
Childhood Leukaemia : Clinical and Epidemiological Information
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| GSTM1 and Breast Cancer
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Millikan R, et al. Glutathione S-transferases M1, T1, and P1 and breast cancer. Cancer Epidemiol Biomarkers Prev 2000 Jun;9(6):567-73 Related articles (PubMed)
Park SK, et al. Alcohol consumption, glutathione S-transferase M1 and T1 genetic polymorphisms and breast cancer risk. Pharmacogenetics 2000 Jun;10(4):301-9 Related articles (PubMed)
Garcia-Closas M, et al. Glutathione S-transferase mu and theta polymorphisms and breast cancer susceptibility. J Natl Cancer Inst 1999 Nov 17;91(22):1960-4 Related articles (PubMed)
Helzlsouer KJ, et al. Association between glutathione S-transferase M1, P1, and T1 genetic polymorphisms and development of breast cancer. J Natl Cancer Inst 1998 Apr 1;90(7):512-8 Related articles (PubMed)
Medline Search: breast cancer AND gstm1 (PubMed)
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Breast Cancer Genetics
Breast Cancer : Clinical and Epidemiological Information
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| GSTM1 and Head and Neck Cancer
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Cheng L, et al. Glutathione-S-transferase polymorphisms and risk of squamous-cell carcinoma of the head and neck. Int J Cancer 1999 Jun 21;84(3):220-4 Related articles (PubMed)
Medline Search: head and neck cancer AND gstm1 (PubMed)
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Head and Neck Cancer Genetics
Head and Neck Cancer : Clinical and Epidemiological Information
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[Home] This page created: 02/12/1999 Last revised: 29/04/2003 © Copyright 1999-
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