CBFA2T1 - Core-binding factor, runt domain, alpha subunit 2; translocated to, 1; cyclin D-related - aka: ETO, MTG8

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CBFA2T1; Core-binding factor, runt domain, alpha subunit 2; translocated to, 1; cyclin D-related (8q22)
CBFA2T1 Menu Summary Information - CBFA2T1 Gene Database Entries for CBFA2T1 Other CBFA2T1 Related Resources t(8;21)(q22;q22) in Acute Myeloid Leukemia Feedback / suggest a new topic for CBFA2T1
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Summary Information
CBFA2T1; Core-binding factor, runt domain, alpha subunit 2; translocated to, 1; cyclin D-related Location: 8q22 Aliases: ETO, MTG8 seen in some AML patients with a translocation t(8;21)(q26;q22) Return to CBFA2T1 Contents
Gene Database Entries for CBFA2T1
OMIM GeneCard (Weizmann Institute) Atlas of Genetics and Cytogenetics in Oncology and Haematology Swiss-Prot Locus Link UniGene GenAtlas GDB Nomenclature (search for CBFA2T1) Return to CBFA2T1 Contents
Other Related Resources
Search Medline for related articles (PubMed) *Medline Search:* cancer AND gene AND (CBFA2T1[TI] OR ETO[TI] OR MTG8[TI]) (PubMed) Limit search to: [Last Year] Limit search to: [Last 2 Years] Limit search to: [Reviews] Return to CBFA2T1 Contents
t(8;21)(q22;q22) in Acute Myeloid Leukemia
The t(8;21) translocation is the most frequent cytogenetic abnormality in acute myeloid leukaemia (AML). The translocation fuses the CBFA2(AML1) gene on chromosome 21q to the CBFA2T1(MTG8 / ETO) gene on chromosome 8q. The resulting fusion gene AML1-ETO occurs more frequently, though not exclusively, in the AML-M2 sub-type. It is detected in approximately 20% of adult and 40% of paediatric patients with AML-M2. McNeil S, et al. The t(8;21) chromosomal translocation in acute myelogenous leukemia modifies intranuclear targeting of the AML1/CBF2 transcription factor Proc Natl Acad Sci USA. 1999; 96(26):14882-7 Related articles Tobal K, Liu Yin JA Molecular monitoring of minimal residual disease in acute myeloblastic leukemia with t(8;21) by RT-PCR Leuk Lymphoma 1998;31(1-2):115-20 Related articles (PubMed) Andrieu V, et al. Molecular detection of t(8;21)/AML1-ETO in AML M1/M2: correlation with cytogenetics, morphology and immunophenotype. Br J Haematol 1996; 92(4):855-65 Related articles (PubMed) *Medline Search:* acute myelogenous leukemia AND translocation AND aml1 AND eto (PubMed) Limit search to: [Last Year] Limit search to: [Last 2 Years] Limit search to: [Reviews] Related Resources Acute Myeloid Leukaemia Genetics Acute Myeloid Leukaemia : Clinical and Epidemiological Information Return to CBFA2T1 Contents
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CBFA2T1; Core-binding factor, runt domain, alpha subunit 2; translocated to, 1; cyclin D-related