Gene Summary

Gene:NIT2; nitrilase family, member 2
Aliases: HEL-S-8a
Databases:HGNC, GeneCard, Gene
Protein:omega-amidase NIT2
Source:NCBIAccessed: 06 August, 2015


What does this gene/protein do?
Show (9)

Cancer Overview

Research Indicators

Publications Per Year (1990-2015)
Graph generated 06 August 2015 using data from PubMed using criteria.

Literature Analysis

Mouse over the terms for more detail; many indicate links which you can click for dedicated pages about the topic.

  • Aminohydrolases
  • Cell Proliferation
  • Acid Anhydride Hydrolases
  • Exonucleases
  • SFN
  • Subcellular Fractions
  • 14-3-3 Proteins
  • AKT1
  • HeLa Cells
  • Tumor Markers
  • G2 Phase
  • Neoplasm Proteins
  • FHIT
  • nitrilase
  • Proteomics
  • Up-Regulation
  • Allelic Imbalance
  • Exoribonucleases
  • Chromosome 3
Tag cloud generated 06 August, 2015 using data from PubMed, MeSH and CancerIndex

Latest Publications: NIT2 (cancer-related)

Lin CH, Chung MY, Chen WB, Chien CH
Growth inhibitory effect of the human NIT2 gene and its allelic imbalance in cancers.
FEBS J. 2007; 274(11):2946-56 [PubMed] Related Publications
The mammalian nitrilase (Nit) protein is a member of the nitrilase superfamily whose function remains to be characterized. We now show that the nitrilase family member 2 gene (NIT2) is ubiquitously expressed in multiple tissues and encodes protein mainly distributed in the cytosol. Ectopic expression of Nit2 in HeLa cells was found to inhibit cell growth through G(2) arrest rather than by apoptosis. Consistent with this, proteomic and RT-PCR analyses showed that Nit2 up-regulated the protein and mRNA levels of 14-3-3sigma, an inhibitor of both G(2)/M progression and protein kinase B (Akt)-activated cell growth, and down-regulated 14-3-3beta, a potential oncogenic protein. Genotype analysis in four types of primary tumor tissues showed 12.5-38.5% allelic imbalance surrounding the NIT2 locus. The results demonstrated that NIT2 plays an important role in cell growth inhibition and links to human malignancies, suggesting that Nit2 may be a potential tumor suppressor candidate.

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Cite this page: Cotterill SJ. NIT2, Cancer Genetics Web: Accessed:

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