|Gene:||MIR1226; microRNA 1226|
|Aliases:||MIRN1226, mir-1226, hsa-mir-1226|
|Summary:||microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]|
|Databases:||miRBase, HGNC, GeneCard, Gene|
|Source:||NCBIAccessed: 06 August, 2015|
Mouse over the terms for more detail; many indicate links which you can click for dedicated pages about the topic.
Data table showing topics related to specific cancers and associated disorders. Scope includes mutations and abnormal protein expression.
|Colorectal Cancer||MicroRNA miR-1226 and Colorectal Cancer||View Publications||1|
|Lung Cancer, Non-Small Cell||MIRN1226 microRNA, human and Non-Small Cell Lung Cancer||View Publications||1|
Note: list is not exhaustive. Number of papers are based on searches of PubMed (click on topic title for arbitrary criteria used).
Numbers shown below represent number of publications held in OncomiRDB database for Oncogenic and Tumor-Suppressive MicroRNAs.
|Tissue||Target Gene(s)||Regulator(s)||MIR1226 Function in Cancer||Effect|
-breast cancer (1)
|MUC1 (1)||increase reactive oxygen species (1)|
reduce the mitochondrial transmembrane potential (1)
decrease cell survival (1)
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Cite this page: Cotterill SJ. MicroRNA miR-1226, Cancer Genetics Web: http://www.cancer-genetics.org/MIR1226.htm Accessed:
This page in Cancer Genetics Web by Simon Cotterill is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
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