|Gene:||CD46; CD46 molecule, complement regulatory protein|
|Aliases:||MCP, TLX, AHUS2, MIC10, TRA2.10|
|Summary:||The protein encoded by this gene is a type I membrane protein and is a regulatory part of the complement system. The encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. In addition, the encoded protein can act as a receptor for the Edmonston strain of measles virus, human herpesvirus-6, and type IV pili of pathogenic Neisseria. Finally, the protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization. Mutations at this locus have been associated with susceptibility to hemolytic uremic syndrome. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jun 2010]|
|Databases:||OMIM, VEGA, HGNC, Ensembl, GeneCard, Gene|
|Protein:||membrane cofactor protein|
|Source:||NCBIAccessed: 25 June, 2015|
What does this gene/protein do?
|Pathways:||What pathways are this gene/protein implicaed in?|
Data table showing topics related to specific cancers and associated disorders. Scope includes mutations and abnormal protein expression.
|Breast Cancer||CD46 and Breast Cancer||View Publications||6|
|Ovarian Cancer||CD46 and Ovarian Cancer||View Publications||5|
|Lung Cancer||CD46 and Lung Cancer||View Publications||5|
|Liver Cancer||CD46 and Liver Cancer||View Publications||4|
|Cervical Cancer||CD46 and Cervical Cancer||View Publications||2|
Note: list is not exhaustive. Number of papers are based on searches of PubMed (click on topic title for arbitrary criteria used).