Gene Summary

Gene:CD46; CD46 molecule, complement regulatory protein
Aliases: MCP, TLX, AHUS2, MIC10, TRA2.10
Summary:The protein encoded by this gene is a type I membrane protein and is a regulatory part of the complement system. The encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. In addition, the encoded protein can act as a receptor for the Edmonston strain of measles virus, human herpesvirus-6, and type IV pili of pathogenic Neisseria. Finally, the protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization. Mutations at this locus have been associated with susceptibility to hemolytic uremic syndrome. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jun 2010]
Databases:OMIM, VEGA, HGNC, Ensembl, GeneCard, Gene
Protein:membrane cofactor protein
Source:NCBIAccessed: 25 June, 2015


What does this gene/protein do?
Show (17)
Pathways:What pathways are this gene/protein implicaed in?
Show (1)

Cancer Overview

Research Indicators

Publications Per Year (1990-2015)
Graph generated 25 June 2015 using data from PubMed using criteria.

Literature Analysis

Mouse over the terms for more detail; many indicate links which you can click for dedicated pages about the topic.

  • Cercopithecus aethiops
  • Gene Expression
  • Measles virus
  • Mice, Inbred BALB C
  • Genetic Vectors
  • Ovarian Cancer
  • Membrane Glycoproteins
  • Apoptosis
  • Viral Vaccines
  • Genetic Therapy
  • Cancer Gene Expression Regulation
  • Complement Activation
  • Liver Cancer
  • Antigens, CD46
  • Cervical Cancer
  • Xenograft Models
  • Oncolytic Virotherapy
  • Cytopathogenic Effect, Viral
  • Breast Cancer
  • Lung Cancer
  • Transduction
  • Cultured Cells
  • CHO Cells
  • Cell Surface Receptors
  • Virus Attachment
  • Chromosome 1
  • Cell Proliferation
  • Oncolytic Viruses
  • Adenoviridae
  • Promoter Regions
  • Cricetinae
  • Cell Line
  • Cytotoxicity, Immunologic
  • Antigens, CD59
  • CD Antigens
  • Messenger RNA
  • Flow Cytometry
  • Coxsackie and Adenovirus Receptor-Like Membrane Protein
  • Receptors, Virus
  • Antigens, CD55
  • siRNA
Tag cloud generated 25 June, 2015 using data from PubMed, MeSH and CancerIndex

Specific Cancers (5)

Data table showing topics related to specific cancers and associated disorders. Scope includes mutations and abnormal protein expression.

Note: list is not exhaustive. Number of papers are based on searches of PubMed (click on topic title for arbitrary criteria used).