 Summary Information
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Location: 1p36
Alias: p73
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| Gene Database Entries for TP73
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OMIM
GeneCard (Weizmann Institute)
Tumor Gene Database
Locus Link
GenAtlas
GDB
Nomenclature (search for TP73)
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| Other Related Resources
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TP73 (UniGene)
 TP53 (17q13.1)
Medline Search: TP73 OR P73 (PubMed)
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- Medline Search: cancer AND gene AND (TP73[TI] OR p73[TI]) (PubMed)
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| Is TP73 a Tumour Supresser Gene ?
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Ichimiya S, et al. Review article: p73: structure and function. Pathol Int 2000 Aug;50(8):589-93 Related articles (PubMed)
Schwartz DI, et al. p73 mutations are not detected in sporadic and hereditary breast cancer. Breast Cancer Res Treat 1999;58(1):25-9 Related articles (PubMed)
Han S, et al. Infrequent somatic mutations of the p73 gene in various human cancers. Eur J Surg Oncol 1999;25(2):194-8 Related articles (PubMed)
Kaghad M, et al. Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers. Cell 1997 Aug 22;90(4):809-19 Related articles (PubMed)
Medline Search: tumor supresser AND (p73[TI] OR tp73[TI]) (PubMed)
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| TP73 and Lung Cancer
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Tokuchi Y, et al. The expression of p73 is increased in lung cancer, independent of p53 gene alteration. Br J Cancer. 1999; 80(10):1623-9 Related articles (PubMed)
Mai M, et al. Activation of p73 silent allele in lung cancer. Cancer Res. 1998; 58(11):2347-9 Related articles (PubMed)
Medline Search: lung cancer AND (p73 OR tp73) (PubMed)
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Lung Cancer Genetics
Lung Cancer : Clinical and Epidemiological Information
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| TP73 and Bladder Cancer
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Chi SG, et al. Elevated and biallelic expression of p73 is associated with progression of human bladder cancer. Cancer Res. 1999; 59(12):2791-3. Related articles (PubMed)
Yokomizo A, et al. Overexpression of the wild type p73 gene in human bladder cancer. Oncogene. 1999; 18(8):1629-33 Related articles (PubMed)
Medline Search: bladder cancer AND (p73 OR tp73) (PubMed)
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Bladder Ca. Genetics
Bladder Ca. : Clinical and Epidemiological Information
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| TP73 and Neuroblastoma
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TP73 was a candidate tumour suppresser gene for neuroblastoma given that a) the gene is homologous to TP53 and b) TP73 is located in the 1p36 region which is frequently deleted in neuroblastoma. However, research suggests that TP73 is infrequently mutated
in neuroblastoma; in a study including tumours detected by mass screening (Ichimiya et al, 1999) only 2 out of 140 neuroblastomas had TP73 mutations; though LOH for TP73 was seen in 19% of tumours with LOH more frequent in neuroblastomas which were
sporadic (not detected by screening), MYCN amplified, and advanced stages. While TP73 may not be a classic Knudson's type tumour supressor gene for neuroblastoma its role in the disease remains to be clarified.
Banelli B, et al. Methylation-independent silencing of the p73 gene in neuroblastoma. Oncogene 2000 Sep 14;19(39):4553-6 Related articles (PubMed)
De Laurenzi V, et al. Induction of neuronal differentiation by p73 in a neuroblastoma cell line. J Biol Chem. 2000 May 19;275(20):15226-31. Related articles (PubMed)
Liu W, et al. Differential expression and allelotyping of the p73 gene in neuroblastoma. Int J Oncol. 2000;16(1):181-5 Related articles (PubMed)
Ichimiya S, et al. p73 at chromosome 1p36.3 is lost in advanced stage neuroblastoma but its mutation is infrequent. Oncogene 1999 Jan 28;18(4):1061-6 Related articles (PubMed)
Takada N, et al. Identification of a transactivation activity in the COOH-terminal region of p73 which is impaired in the naturally occurring mutants found in human neuroblastomas. Cancer Res. 1999 Jun 15;59(12):2810-4. Related articles (PubMed)
Ejeskar K, et al. Variable expression and absence of mutations in p73 in primary neuroblastoma tumors argues against a role in neuroblastoma development. Int J Mol Med. 1999; 3(6):585-9 Related articles (PubMed)
Medline Search: neuroblastoma AND (tp73 OR p73) (PubMed)
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Neuroblastoma Genetics
Neuroblastoma : Clinical and Epidemiological Information
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