|Gene:||RAD52; RAD52 homolog, DNA repair protein|
|Summary:||The protein encoded by this gene shares similarity with Saccharomyces cerevisiae Rad52, a protein important for DNA double-strand break repair and homologous recombination. This gene product was shown to bind single-stranded DNA ends, and mediate the DNA-DNA interaction necessary for the annealing of complementary DNA strands. It was also found to interact with DNA recombination protein RAD51, which suggested its role in RAD51 related DNA recombination and repair. A pseudogene of this gene is present on chromosome 2. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Jul 2014]|
|Databases:||VEGA, OMIM, HGNC, Ensembl, GeneCard, Gene|
|Protein:||DNA repair protein RAD52 homolog|
|Source:||NCBIAccessed: 10 March, 2017|
What does this gene/protein do?
Mouse over the terms for more detail; many indicate links which you can click for dedicated pages about the topic.
Data table showing topics related to specific cancers and associated disorders. Scope includes mutations and abnormal protein expression.
|Breast Cancer||RAD52 and Breast Cancer||View Publications||24|
|Ovarian Cancer||RAD52 and Ovarian Cancer||View Publications||7|
|Lung Cancer||RAD52 and Lung Cancer||View Publications||10|
|Thyroid Cancer||RAD52 and Thyroid Cancer||View Publications||2|
Note: list is not exhaustive. Number of papers are based on searches of PubMed (click on topic title for arbitrary criteria used).
Disclaimer: This site is for educational purposes only; it can not be used in diagnosis or treatment.
Cite this page: Cotterill SJ. RAD52, Cancer Genetics Web: http://www.cancer-genetics.org/RAD52.htm Accessed:
This page in Cancer Genetics Web by Simon Cotterill is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
Note: content of abstracts copyright of respective publishers - seek permission where appropriate.
[Home] Page last revised: 10 March, 2017 Cancer Genetics Web, Established 1999