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CHEK2; CHEK2 (CHK2 checkpoint homolog (S. pombe)) (22q12.1)
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    Summary Information - CHEK2
    Gene Database Entries for CHEK2
    Other CHEK2 Related Resources
    CHEK2 mutations in Li-Fraumeni Syndrome
    CHEK2 mutations in Breast Cancer
    CHEK2 mutations in Osteosarcoma
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  Summary Information

CHEK2; CHEK2 (CHK2 checkpoint homolog (S. pombe))

Location: 22q12.1

Aliases: CHK2, RAD53

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  Gene Database Entries for CHEK2

OMIM
GeneCard (Weizmann Institute)
Swiss-Prot
Locus Link
UniGene
GenAtlas
GDB
Nomenclature (search for CHEK2)

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  Other Related Resources

Search Medline for related articles (PubMed)
  • Medline Search: cancer AND gene AND (CHEK2[TI] OR CHK2[TI] OR RAD53[TI]) (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]
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      CHEK2 mutations in Li-Fraumeni Syndrome

  • Bell DW, et al. Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome. Science 1999; 286(5449):2528-31    Related articles (PubMed)

  • Vahteristo P, et al. p53, CHK2, and CHK1 genes in Finnish families with Li-Fraumeni syndrome: further evidence of CHK2 in inherited cancer predisposition. Cancer Res 2001; 61(15):5718-22    Related articles (PubMed)

  • Lee SB, et al. Destabilization of CHK2 by a missense mutation associated with Li-Fraumeni Syndrome. Cancer Res. 2001; 61(22):8062-7    Related articles (PubMed)

  • Medline Search: Li-Fraumeni syndrome AND (chek2 OR chk2 OR rad53 OR cds1) (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

    Related Resources

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  •   CHEK2 mutations in Breast Cancer

  • Meijers-Heijboer H et al. Low-penetrance susceptibility to breast cancer due to CHEK2*1100delC in noncarriers of BRCA1 or BRCA2 mutations. Nature 2002    Related articles (PubMed)

  • Medline Search: breast cancer AND (chek2 OR chk2 OR rad53 OR cds1) (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

    Related Resources
    Breast Cancer Genetics
    Breast Cancer : Clinical and Epidemiological Information

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  •   CHEK2 mutations in Osteosarcoma

  • Miller CW, et al. Mutations of the CHK2 gene are found in some osteosarcomas, but are rare in breast, lung, and ovarian tumors. Genes Chromosomes Cancer 2002; 33(1):17-21    Related articles (PubMed)

  • Medline Search: osteosarcoma AND (chek2 OR chk2 OR rad53 OR cds1) (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

    Related Resources
    Osteosarcoma Genetics
    Osteosarcoma : Clinical and Epidemiological Information

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