 Summary Information
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Location: 22q12.1
Aliases: CHK2, RAD53
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| Gene Database Entries for CHEK2
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OMIM
GeneCard (Weizmann Institute)
Swiss-Prot
Locus Link
UniGene
GenAtlas
GDB
Nomenclature (search for CHEK2)
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| Other Related Resources
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- Search Medline for related articles (PubMed)
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- Medline Search: cancer AND gene AND (CHEK2[TI] OR CHK2[TI] OR RAD53[TI]) (PubMed)
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| CHEK2 mutations in Li-Fraumeni Syndrome
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Bell DW, et al. Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome. Science 1999; 286(5449):2528-31 Related articles (PubMed)
Vahteristo P, et al. p53, CHK2, and CHK1 genes in Finnish families with Li-Fraumeni syndrome: further evidence of CHK2 in inherited cancer predisposition. Cancer Res 2001; 61(15):5718-22 Related articles (PubMed)
Lee SB, et al. Destabilization of CHK2 by a missense mutation associated with Li-Fraumeni Syndrome. Cancer Res. 2001; 61(22):8062-7 Related articles (PubMed)
Medline Search: Li-Fraumeni syndrome AND (chek2 OR chk2 OR rad53 OR cds1) (PubMed)
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| CHEK2 mutations in Breast Cancer
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Meijers-Heijboer H et al. Low-penetrance susceptibility to breast cancer due to CHEK2*1100delC in noncarriers of BRCA1 or BRCA2 mutations. Nature 2002 Related articles (PubMed)
Medline Search: breast cancer AND (chek2 OR chk2 OR rad53 OR cds1) (PubMed)
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- Related Resources
 Breast Cancer Genetics
Breast Cancer : Clinical and Epidemiological Information
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| CHEK2 mutations in Osteosarcoma
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Miller CW, et al. Mutations of the CHK2 gene are found in some osteosarcomas, but are rare in breast, lung, and ovarian tumors. Genes Chromosomes Cancer 2002; 33(1):17-21 Related articles (PubMed)
Medline Search: osteosarcoma AND (chek2 OR chk2 OR rad53 OR cds1) (PubMed)
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- Related Resources
Osteosarcoma Genetics
Osteosarcoma : Clinical and Epidemiological Information
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[Home] This page created: 25/04/2002 Last revised: 29/04/2003 © Copyright 1999-
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