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AXIN2; Axis Inhibitor 2

Location: 17q23-q24
Alias: AXIL

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OMIM
GeneCard (Weizmann Institute)
Genbank
Locus Link
UniGene
GenAtlas
GDB (search for AXIN2)
Nomenclature (search for AXIN2)

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Search Medline for related articles (PubMed)

Medline Search: cancer AND gene AND (AXIN2[TI] OR AXIL[TI]) (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

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The Axin2 gene was mapped to 17q23-q24 (Mai et al, 1999), a region frequently showing loss of heterozygosity in breast cancer, neuroblastoma, and other tumours.

Mai M, et al. Cloning of the human homolog of conductin (AXIN2), a gene mapping to chromosome 17q23-q24. Genomics. 1999 Feb 1;55(3):341-4.    Related articles (PubMed)

Medline Search: axin2 AND cancer (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

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Liu et al. (2000) found AXIN2 mutations in 11 out of 45 colorectal cancers with defective DNA mismatch repair (MMR). Their research suggests that AXIN2 is overexpressed in colorectal cancer and that AXIN2 mutations effect beta-catenin regulation and the activation of beta-catenin/T-cell factor signalling.

Liu W, et al. Mutations in AXIN2 cause colorectal cancer with defective mismatch repair by activating {beta}-catenin/TCF signalling. (Letter) Nature Genet. 2000; 26: 146-147.    Related articles (PubMed)

Medline Search: axin2 AND colorectal cancer (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

Related Resources
ColoRectal Cancers Genetics
ColoRectal Cancers : Clinical and Epidemiological Information

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