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    t(12; 22)(q13; q12) Translocation in Clear Cell Sarcoma
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ATF1; Activating transcription factor 1

Location: 12q13
Alias: TREB36

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Medline Search: cancer AND gene AND (ATF1[TI] OR TREB36[TI]) (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

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The t(12;22)(q13;q12) is characteristic of malignant melanoma of soft parts (clear cell sarcoma). This fuses the ATF1 gene on chromosome 12 with the EWS gene on chromosome 22.

Lung RW, et al. The cellular oncogene EWS/activating transcription factor 1 is unable to activate adenovirus-borne promoters: implications for cytotoxic prodrug therapy of malignant melanoma of soft parts. Cancer Gene Ther 2000 Mar;7(3):396-406    Related articles (PubMed)

Bosilevac JM, et al. Tumor cell viability in clear cell sarcoma requires DNA binding activity of the EWS/ATF1 fusion protein. J Biol Chem 1999 Dec 3;274(49):34811-8    Related articles (PubMed)

Pellin A, et al. New type of chimeric fusion product between the EWS and ATFI genes in clear cell sarcoma (malignant melanoma of soft parts). Genes Chromosomes Cancer 1998 Dec;23(4):358-60    Related articles (PubMed)

Speleman F, et al. Malignant melanoma of the soft parts (clear-cell sarcoma): confirmation of EWS and ATF-1 gene fusion caused by a t(12;22) translocation. Mod Pathol 1997 May;10(5):496-9    Related articles (PubMed)

Fujimura Y, et al. The EWS-ATF-1 gene involved in malignant melanoma of soft parts with t(12;22) chromosome translocation, encodes a constitutive transcriptional activator. Oncogene 1996 Jan 4;12(1):159-67    Related articles (PubMed)

Zucman J, et al. EWS and ATF-1 gene fusion induced by t(12;22) translocation in malignant melanoma of soft parts. Nat Genet 1993 Aug;4(4):341-5    Related articles (PubMed)

Bridge JA, et al. Chromosomal abnormalities in clear cell sarcoma. Implications for histogenesis. Am J Clin Pathol 1990 Jan;93(1):26-31    Related articles (PubMed)

Medline Search: clear cell sarcoma AND (atf1 OR atf-1) (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

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