D10S170 - H4 Gene - D10S170 DNA segment, single copy, probe pH4 (transforming sequence, thyroid-1) - aka: H4, PTC

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D10S170; H4 Gene - D10S170 DNA segment, single copy, probe pH4 (transforming sequence, thyroid-1) (10q21)
D10S170 Menu Summary Information - D10S170 Gene Database Entries for D10S170 Other D10S170 Related Resources RET/PTC1 (RET-H4) Rearangements in Papillary Thyroid Cancer Feedback / suggest a new topic for D10S170
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Summary Information
D10S170; H4 Gene - D10S170 DNA segment, single copy, probe pH4 (transforming sequence, thyroid-1) Location: 10q21 Aliases: H4, PTC Return to D10S170 Contents
Gene Database Entries for D10S170
OMIM Genbank Locus Link UniGene GDB (search for D10S170) Nomenclature (search for D10S170) Return to D10S170 Contents
Other Related Resources
Search Medline for related articles (PubMed) *Medline Search:* cancer AND gene AND (D10S170[TI] OR H4[TI] OR PTC[TI]) (PubMed) Limit search to: [Last Year] Limit search to: [Last 2 Years] Limit search to: [Reviews] Return to D10S170 Contents
RET/PTC1 (RET-H4) Rearangements in Papillary Thyroid Cancer
The PTC1 fusion gene is present in approximately 30% of papillary thyroid carcinomas. It involves an inversion of 10q which fuses the RET protooncogene to the D10S170 (H4) gene. High incidence of RET/PTC1 rearrangements have been reported in thyroid cancers in people living in areas adjacent to Chernobyl following the nuclear accident. SCID mice transplanted with normal human thyroid tissues and then exposed to radiation preferentially developed RET/PTC1 compared to other RET rearrangements (Mizuno,2000). A FISH study (Nikiforova, 2000) suggests that RET and D10S170 are more frequently juxtaposed in the nucleus of thyroid cells compared to other cells. This close proximity of the genes in thyroid cells may promote the PTC1 fusion since a single radiation track may be sufficient to produce a double-strand break in each gene at the same site in the nucleus. Nikiforova MN, et al. Proximity of Chromosomal Loci That Participate in Radiation-Induced Rearrangements in Human Cells. Science 2000 Oct 6;290(5489):138-141 Related articles (PubMed) Mizuno T, et al. Preferential induction of RET/PTC1 rearrangement by X-ray irradiation. Oncogene 2000 Jan 20;19(3):438-43 Related articles (PubMed) Cho JY, et al. Early cellular abnormalities induced by RET/PTC1 oncogene in thyroid-targeted transgenic mice. Oncogene 1999 Jun 17;18(24):3659-65 Related articles (PubMed) Tong Q, et al. Characterization of the promoter region and oligomerization domain of H4 (D10S170), a gene frequently rearranged with the ret proto-oncogene. Oncogene 1995 May 4;10(9):1781-7 Related articles (PubMed) Sozzi G, et al. Refined localization to contiguous regions on chromosome 10q of the two genes (H4 and RET) that form the oncogenic sequence PTC. Oncogene 1991 Feb;6(2):339-42 Related articles (PubMed) *Medline Search:* thyroid cancer AND ret AND (H4 OR D10S170 OR PTC1) (PubMed) Limit search to: [Last Year] Limit search to: [Last 2 Years] Limit search to: [Reviews] Related Resources Thyroid Cancer Genetics Thyroid Cancer : Clinical and Epidemiological Information Return to D10S170 Contents
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D10S170; H4 Gene - D10S170 DNA segment, single copy, probe pH4 (transforming sequence, thyroid-1)