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HPC1; Hereditary prostate cancer 1 (1q24-q25)
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  Summary Information

HPC1; Hereditary prostate cancer 1

Location: 1q24-q25
Alias: PCS1

Overview: A possible susceptibility locus for hereditary prostate cancer; HPC1 on chromosome 1q24-q25 was first proposed in 1996. Mutations in this locus are noted in some patients with hereditary (families with multiple cases of early-onset) prostate cancer. Approximately 10% of prostate cancer cases are hereditary. Research into HPC1 is ongoing.

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  Gene Database Entries for HPC1

GeneCard (Weizmann Institute)
Locus Link
Nomenclature (search for HPC1)

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  Other Related Resources

Prostate Cancer Genetic Research Study (PROGRESS) (USA) a nationwide research project study which is enrolling families with several men with prostate cancer in order to better understand the disease. The site includes information about the study, Newsletter, publications and links.
Prostate Cancer and the HPC1 Gene (National Center for Biotechnology Information) an overview a of the HPC1 susceptibility locus which may account for about 1 in 500 cases of prostate cancer. Links to other gene databases.
Prostate Cancer Gene Location Found on Chromosome 1 (HPC1) (National Center for Human Genome Research institute, USA) - media release
Prostate Cancer Resources

  • Medline Search: HPC1 (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]
  • Medline Search: Hereditary Prostate Cancer (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]
    Search Medline for related articles (PubMed)
  • Medline Search: cancer AND gene AND (HPC1[TI] OR PCS1[TI]) (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]
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  •   HPC1 and Familial Prostate Cancer

    Hereditary prostate cancer accounts for about 9% of prostate cancer cases. A prostate cancer susceptibility locus (HPC1) on chromosome 1q24-25 was idenified by Smith et al, 1996. However, subsiquent studies osuggest that mutations in HPC1 are uncommon and are restricted to people with early onset disease. In a study of "small" families [3-5 affected members], Dunsmuir WD et al. (1998) found less than 8% of cases had allelic loss in HPC1. Other specific gene(s) associated with this have yet to be identified.

  • Dunsmuir WD, et al. Allelic imbalance in familial and sporadic prostate cancer at the putative human prostate cancer susceptibility locus, HPC1. CRC/BPG UK Familial Prostate Cancer Study Collaborators. Cancer Research Campaign/British Prostate Group. Br J Cancer 1998;78(11):1430-3    Related articles (PubMed)

  • Gronberg H, et al. In Swedish families with hereditary prostate cancer, linkage to the HPC1 locus on chromosome 1q24-25 is restricted to families with early-onset prostate cancer. Am J Hum Genet. 1999;65(1):134-40    Related articles (PubMed)

  • McIndoe RA, et al. Linkage analysis of 49 high-risk families does not support a common familial prostate cancer-susceptibility gene at 1q24-25. Am J Hum Genet 1997; 61(2):347-53    Related articles (PubMed)

  • Smith JR, et al. Major susceptibility locus for prostate cancer on chromosome 1 suggested by a genome-wide search. Science. 1996;274(5291):1371-4    Related articles (PubMed)

    Related Resources
    Familial Prostate Cancer
    PCAP (HPC2) gene 1q42.2-1q43
    Prostate Cancer Genetics
    Prostate Cancer : Clinical and Epidemiological Information

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