Gene Summary

Gene:CD63; CD63 molecule
Aliases: MLA1, ME491, LAMP-3, OMA81H, TSPAN30
Summary:The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The encoded protein is a cell surface glycoprotein that is known to complex with integrins. It may function as a blood platelet activation marker. Deficiency of this protein is associated with Hermansky-Pudlak syndrome. Also this gene has been associated with tumor progression. Alternative splicing results in multiple transcript variants encoding different protein isoforms. [provided by RefSeq, Apr 2012]
Databases:OMIM, HGNC, Ensembl, GeneCard, Gene
Protein:CD63 antigen
Source:NCBIAccessed: 31 August, 2019


What does this gene/protein do?
Show (21)

Cancer Overview

Research Indicators

Publications Per Year (1994-2019)
Graph generated 31 August 2019 using data from PubMed using criteria.

Literature Analysis

Mouse over the terms for more detail; many indicate links which you can click for dedicated pages about the topic.

  • CD63
  • Membrane Glycoproteins
  • Gene Expression Profiling
  • Cell Movement
  • Precipitin Tests
  • Cancer Gene Expression Regulation
  • Neoplasm Proteins
  • Flow Cytometry
  • Tissue Inhibitor of Metalloproteinases
  • src-Family Kinases
  • CD Antigens
  • Exosomes
  • Biomarkers, Tumor
  • Chromosome 12
  • Proto-Oncogene Proteins c-kit
  • Oligonucleotide Array Sequence Analysis
  • Lung Cancer
  • Cancer RNA
  • Tetraspanin 29
  • Tumor Antigens
  • Thyroid Cancer
  • Platelet Membrane Glycoproteins
  • Cell Proliferation
  • Melanoma
  • Membrane Proteins
  • Breast Cancer
  • Messenger RNA
  • Mutation
  • Phenotype
  • Stromal Cells
  • Immunohistochemistry
  • TIMP1
  • Protein Transport
  • Cell Survival
  • Kangai-1 Protein
  • Neoplasm Invasiveness
  • Signal Transduction
  • Disease Progression
  • Wound Healing
  • Gene Expression
  • Tetraspanin 30
Tag cloud generated 31 August, 2019 using data from PubMed, MeSH and CancerIndex

Specific Cancers (3)

Data table showing topics related to specific cancers and associated disorders. Scope includes mutations and abnormal protein expression.

Note: list is not exhaustive. Number of papers are based on searches of PubMed (click on topic title for arbitrary criteria used).

Latest Publications: CD63 (cancer-related)

Disclaimer: This site is for educational purposes only; it can not be used in diagnosis or treatment.

Cite this page: Cotterill SJ. CD63, Cancer Genetics Web: Accessed:

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This page in Cancer Genetics Web by Simon Cotterill is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
Note: content of abstracts copyright of respective publishers - seek permission where appropriate.

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