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Contents
Genes Implicated in Drug Resistance
Genes Implicated in Drug Metabolism
Pharmacogenetics and Cancer Chemotherapy
Chemotherapy and Pharmacology Resources
  Genes Implicated in Drug Resistance
GeneLocationTopics
ABCC5 ( MRP5 , MOAT-C , SMRP ) 3q27 -MRP5 Expression and Drug Resistance in Lung Cancer
ABCG2 ( BCRP , MXR1 ) 4q22 -BCRP and Drug Resistance in Cancer
ALDH1 ( PUMB1 ) 9q21 -ALDH1 and Aquired Cyclophosphamide Drug Resistance
BCAR116q23.1 -BCAR1 and Tamoxifen Resistance in Breast Cancer
BCAR3 ( NSP2 ) -BCAR3 and Breast Cancer
FGF2 ( FGFB , BFGF ) 4q25-q27 -FGF2 and Drug Resistance
MGMT10q26 -MGMT Function and Drug Resistance
-MGMT and Drug Resistance Gene Therapy
MRP ( MRP1 , ABCC1 ) 16p13.1 -Defining Texts
-MRP1 and Neuroblastoma
-MRP1 and Acute Myeloid Leukaemia
-MRP1 Deletion in Acute Myeloid Leukaemia with INV(16)
TOP120q12-q13.1 -TOP1 Expression in Seminomas
TOP2A ( TOP2 ) 17q21-q22 -TOP2A Expression in Esophageal Cancer
TOP2B3p? -
TP53 ( p53 , P53 ) 17p13.1 -TP53 and Drug Resistance in Lung Cancer

 

  Genes Implicated in Drug Metabolism
GeneLocationTopics
DPYD ( DPD ) 1p22 -DPYD and 5- fluorouracil Toxicity
TPMT6p22.3 -TPMT Expression in Leukaemia
-TPMT Expression in Childhood Acute Lymphocytic Leukaemia

 

  Pharmacogenetics and Cancer Chemotherapy

  • Nebert DW Pharmacogenetics and pharmacogenomics: why is this relevant to the clinical geneticist? [Review] Clin Genet 1999 Oct;56(4):247-58    Related articles (PubMed)

  • Iyer L, Ratain MJ Pharmacogenetics and cancer chemotherapy. [Review] Eur J Cancer 1998 Sep;34(10):1493-9    Related articles (PubMed)

  • Medline Search: pharmacogenetics AND cancer (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

     

  •   Polymorphisms and Drug Metabolism in Cancer

  • Iyer L Inherited variations in drug-metabolizing enzymes: significance in clinical oncology. [Review] Mol Diagn 1999 Dec;4(4):327-33    Related articles (PubMed)

  • Krynetski EY, Evans WE Pharmacogenetics as a molecular basis for individualized drug therapy: the thiopurine S-methyltransferase paradigm. [Review] Pharm Res 1999 Mar;16(3):342-9    Related articles (PubMed)

  • Medline Search: polymorphism AND drug metabolism AND cancer (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

     

  •   Multi-drug Resistance and Cancer

  • van den Heuvel-Eibrink MM, et al. The prognostic significance of membrane transport-associated multidrug resistance (MDR) proteins in leukemia. Int J Clin Pharmacol Ther 2000 Mar;38(3):94-110    Related articles (PubMed)

  • Medline Search: multi-drug resistance AND cancer (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

     

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