Genetic Epidemiology

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Disclaimer: This site is for educational purposes only; it can not be used in diagnosis or treatment.

This page is under construction. It is intended that this page will contain a table of genes/SNPs thought to be related to cancer risk in the context of gene-environment interactions + links related genetic epidemiology web sites.

Contents

Polymorphisms Implicated in Cancer Susceptibility
Genetic Epidemiology of Cancer
Links to Other Genetic Epidemiology Sites

Polymorphisms Implicated in Cancer Susceptibility
Gene	Location	Topics
ALDH2	12q24.2	-ALDH2 Polymorphisms and Cancer
APC ( FPC , DP2 , DP3 )	5q21-q22	-APC I1307K Polymorphism in Colorectal Cancer
CCND1 ( D11S287E , Cyclin D , PRAD1 )	11q13	-CCND1 and Head and Neck Cancers
CDKN2A ( P16 , INK4A , MTS1 )	9p21	-CDKN2A Polymorphisms and Mole Density ?
COMT	22q11.2	-COMT Polymorphisms and Breast Cancer
CYP17	10q24.3	-CYP17 and Prostate Cancer -CYP17 and Breast Cancer -CYP17 and Male Breast Cancer
CYP19	15q21.1	-CYP19 Polymorphisms and Breast Cancer Risk
CYP1A1 ( CYP1 )	15q22-q24	-CYP1A1 and Lung Cancer -CYP1A1 and Oral Cancer -CYP1A1 and Childhood Leukaemia -CYP1A1 and Breast Cancer
CYP1B1 ( GLC3A )	2p22-p21	-CYP1B1 Polymorphisms in Breast Cancer
CYP2A6	19q13.2	-CYP2A6 and Lung Cancer -CYP2A6 and Nicotine Metabolism
CYP2E ( CYP2E1 )	10q24.3-qter	-CYP2E and Lung Cancer
GSTM1 ( GST1 , MU )	1p13.3	-Tabacco smoke, GSTM1 and Suceptability to Lung Cancer -GSTM1 and Bladder Cancer -GSTM1 and Childhood Leukaemia -GSTM1 and Breast Cancer
GSTP1 ( FAEES3 , GST3 , PI )	11q13	-GSTP1 Polymorphisms and Breast Cancer
GSTT1	22q11.23 ?	-GSTT1 and Head and Neck Cancers -GSTT1 Polymorphisms and Breast Cancer -GSTT1 Polymorphisms and Head and Neck Cancer
HRAS	11p15.5	-HRAS Minisatellite Alleles and Cancer Susceptibility -HRAS Minisatellite Alleles and Breast Cancer Risk -HRAS Minisatellite Alleles and Ovarian Cancer Risk -HRAS Minisatellite Alleles and Lung Cancer Risk -HRAS Minisatellite Alleles and Colorectal Cancer Risk
LTA ( TNFB , LT )	6p21.3	-LTA Polymorphisms and Risk of MGUS and Myeloma
MC1R ( MSH-R )	16q24.3	-MC1R Polymorphisms and Melanoma
MTHFR ( NADPH )	1p36.3	-MTHFR and Colon Cancer -MTHFR and Acute Lymphoblastic Leukaemia
MUC1 ( PUM , PEM )	1q21	-Defining Texts
MUC6	11p15.5-p15.4	-
NAT1 ( AAC1 )	8p23.1-p21.3	-NAT1 and Bladder Cancer -NAT1 and Lung Cancer
NAT2 ( AAC2 )	8p23.1-p21.3	-NAT2 and Bladder Cancer -NAT2 and Colorectal Cancer
PPP1R3 ( PP1G )	7q31?	-PPP1R3 and Cancer
SRD5A2	2p23	-SRD5A2 and Prostate Cancer -SRD5A2 and Breast Cancer
TNF ( TNFA , TNFSF2 , DIF )	6p21.3	-TNF Polymorphisms and Risk of MGUS and Myeloma

Genetic Epidemiology
Collins A, et al. Genetic epidemiology of single-nucleotide polymorphisms Proc Natl Acad Sci USA. 1999 96(26), 15173-7 Goldstein AM, Andrieu N Detection of interaction involving identified genes: available study designs. J Natl Cancer Inst Monogr 1999;(26):49-54 Related articles (PubMed) Bartsch H, et al. Genetic cancer susceptibility and DNA adducts: studies in smokers, tobacco chewers, and coke oven workers. Cancer Detect Prev. 1999; 23(6):445-53. Related articles (PubMed) Spitz MR, et al. Genetic susceptibility to tobacco carcinogenesis. [Review] Cancer Invest 1999;17(8):645-59 Related articles (PubMed) Shields PG. Molecular epidemiology of lung cancer. [Review] Ann Oncol 1999;10 Suppl 5:S7-11 Related articles (PubMed)
Genetic Epidemiology of Childhood Cancers
Shannon K. Genetic predispositions and childhood cancer. [Review] Environ Health Perspect 1998;106 Suppl 3:801-6 Related articles (PubMed) Related Resources Childhood Cancer Genetics (Menu) Heritable Proportion of Childhood Cancers
Diet-Gene Interactions
Rock CL, et al. Nutrition, genetics, and risks of cancer. Annu Rev Public Health 2000;21:47-64 Related articles (PubMed)
Radiation-Gene Interactions
Neta R The promise of molecular epidemiology in defining the association between radiation and cancer. [Review] Health Phys 2000 Jul;79(1):77-84 Related articles (PubMed)
Familial Clustering of Cancer
Petersen GM Familial Aggregation: Sorting Susceptibility From Shared Environment. [Editorial] J Natl Cancer Inst 2000 Jul 19;92(14):1114-1115 Related articles (PubMed) Khoury MJ, et al. Can familial aggregation of disease be explained by familial aggregation of environmental risk factors? Am J Epidemiol 1988 Mar;127(3):674-83 Related articles (PubMed)

Genetic Epidemiology Links (14 links)

S.A.G.E. (Statistical Analysis for Genetic Epidemiology) (Case Western Reserve University, USA) software funded by the NIH National Center for Research Resources
Genetic Epidemiology Page (University of California, San Diego)
Laboratory of Statistical Genetics - Genetic Linkage Analysis (Rockefeller University, USA)
Human Population Genetics Laboratory (Stamford University, USA)
Quantitative Genetic Epidemiology (Fred Hutchinson Cancer Center, USA)
Epidemiology And Clinical Trials Interest Group This is a Special Interest Group of the National Institutes of Health with membership open to researchers in other DHHS agencies. The Web site includes details of membership, meetings and seminars, and Email archives.
International Genetic Epidemiology Society (IGES) The Society is devoted to the development of the methodology for, and undertaking of studies of disease in a manner that integrates both host and environmental factors. The Web site includes details of membership, meetings, committees and announcements.
GenTools Software (GenLink) Software for analysis and manipulation of genetic linkage data
University of Melbourne: Genetic Epidemiology Unit (Australia) details of the unit which includes the Australian NHMRC Twin Registry and Australian Breast Cancer Family Study.
HUM-MOLGEN computational genetics resource
Karolinska Institute: Division of Genetic Epidemiology (Sweden) overview of ongoing studies including the Swedish Twin Registry.
Environmental and Molecular Mutagenesis (Journal)
National Society of Genetic Counselors, Inc (USA)
Genetic Epidemiology (Journal)

See also

Cancer Epidemiology
See also

Genetic Counselling