Genes Implicated in Familial Cancers
|
Gene | Location | Topics
|
APC (
FPC
, DP2
, DP3
)
| 5q21-q22
|
-APC and Familial Adenomatous Polyposis
-APC and Adrenocortical Carcinoma (FAP Associated)
-APC and Hepatoblastoma (FAP Associated)
-APC and Thyroid Cancer (FAP Associated)
|
BRCA1 | 17q21
|
-Hereditary Breast and Ovarian Cancer Syndromes
-Prophylactic Treatments for Women with BRAC1 mutations
|
BRCA2 | 13q12.3
|
-BRCA2 in Familial Breast Cancer
-Prophylactic Treatments for Women with BRAC2 mutations
|
CDH1 (
UVO
)
| 16q22.1
|
-CDH1 Mutations in Familial Gastric Cancer
|
CDK4 (
PSK-J3
)
| 12q14
|
-CDK4 Germline Mutations in Melanoma Prone Families
|
CDKN2A (
P16
, INK4A
, MTS1
)
| 9p21
|
-CDKN2A Germline Mutations in Melanoma Prone Families
-Screening for CDKN2A Mutations in Melanoma Prone Families
-CDKN2A Mutation in Pancreatic Cancer
-CDKN2A Mutation and Breast Cancer
|
EXT1 | 8q24.11-q24.13
|
-EXT1 and Hereditary Multiple Exostoses
|
EXT2 | 11p12-p11
|
-EXT2 and Hereditary Multiple Exostoses
|
HFE (
HLA-H
)
| 6p21.3
|
-HFE Mutations in Hepatocellular Carcinoma
|
HPC1 (
PCS1
)
| 1q24-q25
|
-HPC1 and Familial Prostate Cancer
|
HPCX | Xq27-q28
|
-HPCX and Hereditary Prostate Cancer
|
MET (
HGFR
, c-met
)
| 7q31
|
-MET and Hereditary Papillary Renal Carcinoma
|
MLH1 (
HNPCC2
, COCA2
, FCC2
)
| 3p21.3
|
-MLH1 and Hereditary NonPolyposis Colorectal Cancer
-MLH1 and Familial Gastric Cancer
|
MSH2 (
HNPCC1
, COCA1
, FCC1
)
| 2p22-p21
|
-MSH2 and Hereditary NonPolyposis Colorectal Cancer
|
NBS1 | 8q21
|
-Nijmegen Breakage Syndrome
|
NF1 | 17q11.2
|
-NF1 and Neurofibromatosis Type 1
|
PCAP (
HPC2
)
| 1q42.2-1q43
|
-PCAP and Familial Prostate Cancer
|
PMS1 (
PMSL1
)
| 2q31-q33
|
-PMS1 and Hereditary NonPolyposis Colon Cancer
|
PMS2 (
PMSL2
)
| 7p22
|
-PMS2 and Hereditary NonPolyposis Colon Cancer
|
RB1 (
Rb
)
| 13q14.2
|
-The RB Tumour Supressor Family of Genes
|
RCA1 (
HRCA1
, TRC8
)
| 3p14.2-3p14.2
|
-t(3;8)(p14.2;q24.1) in Hereditary Renal Cell Carcinoma
|
RET (
PTC
, MEN2A
, MEN2B
)
| 10q11.2
|
-RET and Familial Medullary Thyroid Carcinoma
|
SMARCB1 (
INI1
, SNF5
, BAF47
)
| 22q11
|
-SMARCB1 and Familial Cancer ?
|
TOC (
TOCG
)
| 17q24
|
-TOC Locus Implicated in Esophageal Cancer
|
|