Cancer GeneticsWeb
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  The Hereditiable Proportion of Cancers

  • Narod SA, et al. An estimate of the heritable fraction of childhood cancer. Br J Cancer 1991 Jun;63(6):993-9    Related articles (PubMed)


  •   Twin Studies

  • Lichtenstein P, et al. Environmental and heritable factors in the causation of cancer--analyses of cohorts of twins from Sweden, Denmark, and Finland. N Engl J Med 2000 Jul 13;343(2):78-85    Related articles (PubMed)

  • Ahlbom A, et al. Cancer in twins: genetic and nongenetic familial risk factors. J Natl Cancer Inst 1997 Feb 19;89(4):287-93    Related articles (PubMed)

  • Medline Search: cancer AND twin (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]


  •   Twin Studies of Breast Cancer

  • el-Rifai W, et al. DNA copy number losses at 1p32-pter in monozygotic twins concordant for breast cancer. Cancer Genet Cytogenet 1999 Jul 15;112(2):169-72    Related articles (PubMed)

  • Verkasalo PK, et al. Breast cancer risk in monozygotic and dizygotic female twins: a 20-year population-based cohort study in Finland from 1976 to 1995. Cancer Epidemiol Biomarkers Prev 1999 Mar;8(3):271-4    Related articles (PubMed)

  • Medline Search: breast cancer AND twin (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]


  •   Twin Studies of Hodgkin's Disease

  • Mack TM, et al. Concordance for Hodgkin's disease in identical twins suggesting genetic susceptibility to the young-adult form of the disease. N Engl J Med 1995 Feb 16;332(7):413-8    Related articles (PubMed)

  • Medline Search: Hodgkin's disease AND twin (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]


  •   Twin Studies of Melanoma

  • Bataille V, et al. Genetics of Risk Factors for Melanoma: an Adult Twin Study of Nevi and Freckles J Natl Cancer Inst. 2000; 92(6): 457-463    Related articles

  • Medline Search: melanoma AND twin (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]


  •   Twin Studies of Childhood Cancer

  • Buckley JD, et al. Concordance for childhood cancer in twins. Med Pediatr Oncol 1996 Apr;26(4):223-9    Related articles (PubMed)

  • Knox EG, et al. Leukaemia and childhood cancer in twins. J Epidemiol Community Health 1984 Mar;38(1):12-6    Related articles (PubMed)

  • Medline Search: childhood cancer AND twin (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]


  •   Role of Primary Care in Genetics Services for Famililal Cancer

  • Acton RT, et al. Knowledge, attitudes, and behaviors of Alabama's primary care physicians regarding cancer genetics. Acad Med 2000 Aug;75(8):850-2    Related articles (PubMed)

  • Carroll JC, et al. Hereditary breast cancer. Psychosocial issues and family physicians' role. Can Fam Physician 1999 Jan;45:126-32    Related articles (PubMed)

  • Emery J, et al. Computer support for interpreting family histories of breast and ovarian cancer in primary care: comparative study with simulated cases. BMJ 2000 Jul 1;321(7252):28-32    Related articles (PubMed)

  • Elsas LJ 2nd, et al. Cancer genetics in primary care. When is genetic screening an option and when is it the standard of care? Postgrad Med 2000 Apr;107(4):191-4, 197-200, 205-8    Related articles (PubMed)

  • Fowler MC Outcomes for patients at risk for inheritable breast cancer: how the nurse practitioner can determine the proper course of action to ensure desired outcomes. Nurse Pract Forum 1999 Dec;10(4):204-7    Related articles (PubMed)

  • Emery J Evaluation of questionnaire on cancer family history in general practice. Principal role of primary care is not to seek out those at increased genetic risk. BMJ 2000 Jan 15;320(7228):186-7    Related articles (PubMed)

  • Worthen HG Inherited cancer and the primary care physician. Barriers and strategies. Cancer 1999 Dec 1;86(11 Suppl):2583-8    Related articles (PubMed)

  • Fry A, et al. GPs' views on their role in cancer genetics services and current practice. Fam Pract 1999 Oct;16(5):468-74    Related articles (PubMed)

  • de Bock GH, et al. GPs' management of women seeking help for familial breast cancer. Fam Pract 1999 Oct;16(5):463-7    Related articles (PubMed)

  • Medline Search: primary care AND cancer AND genetics (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]


  •   Genes Implicated in Familial Cancers
    APC ( FPC , DP2 , DP3 ) 5q21-q22 -APC and Familial Adenomatous Polyposis
    -APC and Adrenocortical Carcinoma (FAP Associated)
    -APC and Hepatoblastoma (FAP Associated)
    -APC and Thyroid Cancer (FAP Associated)
    BRCA117q21 -Hereditary Breast and Ovarian Cancer Syndromes
    -Prophylactic Treatments for Women with BRAC1 mutations
    BRCA213q12.3 -BRCA2 in Familial Breast Cancer
    -Prophylactic Treatments for Women with BRAC2 mutations
    CDH1 ( UVO ) 16q22.1 -CDH1 Mutations in Familial Gastric Cancer
    CDK4 ( PSK-J3 ) 12q14 -CDK4 Germline Mutations in Melanoma Prone Families
    CDKN2A ( P16 , INK4A , MTS1 ) 9p21 -CDKN2A Germline Mutations in Melanoma Prone Families
    -Screening for CDKN2A Mutations in Melanoma Prone Families
    -CDKN2A Mutation in Pancreatic Cancer
    -CDKN2A Mutation and Breast Cancer
    EXT18q24.11-q24.13 -EXT1 and Hereditary Multiple Exostoses
    EXT211p12-p11 -EXT2 and Hereditary Multiple Exostoses
    HFE ( HLA-H ) 6p21.3 -HFE Mutations in Hepatocellular Carcinoma
    HPC1 ( PCS1 ) 1q24-q25 -HPC1 and Familial Prostate Cancer
    HPCXXq27-q28 -HPCX and Hereditary Prostate Cancer
    MET ( HGFR , c-met ) 7q31 -MET and Hereditary Papillary Renal Carcinoma
    MLH1 ( HNPCC2 , COCA2 , FCC2 ) 3p21.3 -MLH1 and Hereditary NonPolyposis Colorectal Cancer
    -MLH1 and Familial Gastric Cancer
    MSH2 ( HNPCC1 , COCA1 , FCC1 ) 2p22-p21 -MSH2 and Hereditary NonPolyposis Colorectal Cancer
    NBS18q21 -Nijmegen Breakage Syndrome
    NF117q11.2 -NF1 and Neurofibromatosis Type 1
    PCAP ( HPC2 ) 1q42.2-1q43 -PCAP and Familial Prostate Cancer
    PMS1 ( PMSL1 ) 2q31-q33 -PMS1 and Hereditary NonPolyposis Colon Cancer
    PMS2 ( PMSL2 ) 7p22 -PMS2 and Hereditary NonPolyposis Colon Cancer
    RB1 ( Rb ) 13q14.2 -The RB Tumour Supressor Family of Genes
    RCA1 ( HRCA1 , TRC8 ) 3p14.2-3p14.2 -t(3;8)(p14.2;q24.1) in Hereditary Renal Cell Carcinoma
    RET ( PTC , MEN2A , MEN2B ) 10q11.2 -RET and Familial Medullary Thyroid Carcinoma
    SMARCB1 ( INI1 , SNF5 , BAF47 ) 22q11 -SMARCB1 and Familial Cancer ?
    TOC ( TOCG ) 17q24 -TOC Locus Implicated in Esophageal Cancer


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