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  Chromosome 20

Genes Linked with Cancer (52)

How to use this data table Click on the gene name for detailed information. Type in the Search box e.g. 'germline' or 'Breast Cancer' to search within Chromosome 20; or Sort by clicking on a column heading e.g. 'Gene'.

Gene Location Aliases Abnormalities Implicated in
PCNA 20pter-p12 ATLD2Somatic-Breast Cancer
-Colorectal Cancer
-Eye Cancer
-Liver Cancer
-Lung Cancer
-Stomach Cancer
FOXA2 20p11 HNF3B, TCF3B-Liver Cancer
-Lung Cancer
-Prostate Cancer
-Skin Cancer
-Stomach Cancer
PYGB 20p11.21 GPBB
BMP2 20p12 BDA2, BMP2A-Bone Cancer (primary)
-Breast Cancer
-Colorectal Cancer
-Lung Cancer
-Osteosarcoma
-Prostate Cancer
JAG1 20p12.1-p11.23 AGS, AHD, AWS, HJ1, CD339, JAGL1-Breast Cancer
RASSF2 20p13 CENP-34, RASFADIN
Methylation
-Cervical Cancer
-Colorectal Cancer
-Ovarian Cancer
-Stomach Cancer
-Thyroid Cancer
CDC25B 20p13 -Breast Cancer
-Cervical Cancer
-Esophageal Cancer
-Lung Cancer
ASXL1 20q11 MDS, BOPSSomatic-Acute Myeloid Leukaemia
-Childhood Cancers
-Myelodysplastic Syndromes
-Myeloproliferative Disorders
TPX2 20q11.2 DIL2, p100, DIL-2, HCTP4, FLS353, HCA519, REPP86, C20orf1, C20orf2, GD:C20orf1-Breast Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
GHRH 20q11.2 GRF, INN, GHRF-Breast Cancer
-Oral Cavity Cancer
-Pancreatic Cancer
-Pituitary Tumors
-Prostate Cancer
DNMT3B 20q11.2 ICF, ICF1, M.HsaIIIB-Breast Cancer
-Colorectal Cancer
-Liver Cancer
-Lung Cancer
-Testicular Cancer
ASIP 20q11.2-q12 ASP, AGSW, AGTI, AGTIL, SHEP9-Melanoma
-Skin Cancer
-Basal Cell Carcinoma (BCC) - Skin
NNAT 20q11.2-q12 Peg5-Acute Lymphocytic Leukaemia (ALL)
-Breast Cancer
-Childhood Cancers
-Colorectal Cancer
-Kidney Cancer
-Lung Cancer
-Pituitary Tumors
MMP9 20q11.2-q13.1 GELB, CLG4B, MMP-9, MANDP2-Cervical Cancer
-Uterine Sarcoma
RBL1 20q11.2 PRB1, p107, CP107-Cervical Cancer
-Retinoblastoma
E2F1 20q11.2 RBP3, E2F-1, RBAP1, RBBP3-Breast Cancer
-Liver Cancer
-Prostate Cancer
MAFB 20q11.2-q13.1 KRML, MCTOSomatic
Translocation
Overexpression
-Multiple Myeloma
BCL2L1 20q11.21 BCLX, BCL2L, BCLXL, BCLXS, Bcl-X, bcl-xL, bcl-xS, PPP1R52, BCL-XL/S-Breast Cancer
-Lung Cancer
-Ovarian Cancer
ITCH 20q11.22 AIF4, AIP4, ADMFD, NAPP1, dJ468O1.1-Melanoma
-Multiple Endocrine Neoplasia
-Skin Cancer
TOP1 20q12-q13.1 TOPISomatic
Translocation
-Acute Myeloid Leukaemia
-Breast Cancer
-Cervical Cancer
-Colorectal Cancer
-Neuroblastoma
-Soft Tissue Sarcoma
-Testicular Cancer
SRC 20q12-q13 ASV, SRC1, c-SRC, p60-Src-Breast Cancer
-Lung Cancer
-Prostate Cancer
CD40 20q12-q13.2 p50, Bp50, CDW40, TNFRSF5-Chronic Lymphocytic Leukemia
-Kaposi Sarcoma
-Liver Cancer
-Stomach Cancer
-Thymoma and Thymic Carcinoma
SDC4 20q12 SYND4Somatic-Bladder Cancer
-Brain Tumours, Childhood
-Breast Cancer
SLPI 20q12 ALP, MPI, ALK1, BLPI, HUSI, WAP4, WFDC4, HUSI-I-Breast Cancer
-Cervical Cancer
-Lung Cancer
-Ovarian Cancer
-Stomach Cancer
-Uterine Sarcoma
PTPRT 20q12-q13 RPTPrho-Breast Cancer
-Melanoma
-Skin Cancer
SULF2 20q12-q13.2 HSULF-2-Breast Cancer
-Liver Cancer
-Lung Cancer
NCOA3 20q12 ACTR, AIB1, RAC3, SRC3, pCIP, AIB-1, CTG26, SRC-3, CAGH16, KAT13B, TNRC14, TNRC16, TRAM-1, bHLHe42-Breast Cancer
-Prostate Cancer
CYP24A1 20q13 CP24, HCAI, CYP24, P450-CC24-Breast Cancer
-Colorectal Cancer
-Lung Cancer
-Prostate Cancer
BMP7 20q13 OP-1-Bone Cancer (primary)
-Breast Cancer
-Eye Cancer
-Lung Cancer
-Melanoma
-Prostate Cancer
AURKA 20q13 AIK, ARK1, AURA, BTAK, STK6, STK7, STK15, AURORA2, PPP1R47-Bladder Cancer
-Breast Cancer
-Skin Cancer
-Stomach Cancer
-Uterine Sarcoma
PTPN1 20q13.1-q13.2 PTP1B-Breast Cancer
-Esophageal Cancer
CEBPB 20q13.1 TCF5, IL6DBP, NF-IL6, C/EBP-beta-Acute Myeloid Leukaemia
-Bladder Cancer
-Cervical Cancer
MYBL2 20q13.1 BMYB, B-MYBOverexpression-Breast Cancer
-Cervical Cancer
-Liver Cancer
-Neuroblastoma
-Prostate Cancer
UBE2C 20q13.12 UBCH10, dJ447F3.2-Bladder Cancer
-Breast Cancer
-Cervical Cancer
-Colorectal Cancer
-Lung Cancer
-Prostate Cancer
HNF4A 20q13.12 TCF, HNF4, MODY, FRTS4, MODY1, NR2A1, TCF14, HNF4a7, HNF4a8, HNF4a9, NR2A21, HNF4alpha-Colorectal Cancer
-Liver Cancer
WISP2 20q13.12 CCN5, CT58, CTGF-L-Adrenocortical Cancer
-Breast Cancer
SALL4 20q13.2 DRRS, HSAL4, ZNF797, dJ1112F19.1-Acute Myeloid Leukaemia
-Chronic Myelogenous Leukemia
-Leukaemia
-Ovarian Cancer
ZNF217 20q13.2 ZABC1-Breast Cancer
-Colorectal Cancer
-Ovarian Cancer
-Stomach Cancer
TFAP2C 20q13.2 ERF1, TFAP2G, hAP-2g, AP2-GAMMA-Acute Myeloid Leukaemia
-Breast Cancer
-Leukaemia
-Melanoma
SNAI1 20q13.2 SNA, SNAH, SNAIL, SLUGH2, SNAIL1, dJ710H13.1-Breast Cancer
-Colorectal Cancer
-Liver Cancer
-Lung Cancer
-Ovarian Cancer
-Stomach Cancer
BCAS1 20q13.2 AIBC1, NABC1-Breast Cancer
NFATC2 20q13.2 NFAT1, NFATPSomatic
Translocation
-Bone Cancer (primary)
-Breast Cancer
-Ewing's Sarcoma
-Pancreatic Cancer
TNFRSF6B 20q13.3 M68, TR6, DCR3, M68E, DJ583P15.1.1Somatic
Amplification
Overexpression
Many cancer types including:
-Colorectal Cancer
-Esophageal Cancer
-Liver Cancer
-Lung Cancer
-Pancreatic Cancer
-Stomach Cancer
-Chemotherapy
RTEL1 20q13.3 NHL, RTEL, DKCA4, DKCB5, C20orf41-Astrocytoma, Childhood
-Brain and CNS Tumours
-Brain Stem Glioma, Childhood
-Brain Tumours, Childhood
-Melanoma
-Skin Cancer
GNAS 20q13.3 AHO, GSA, GSP, POH, GPSA, NESP, GNAS1, PHP1A, PHP1B, PHP1C, C20orf45Somatic-Bladder Cancer
-Pancreatic Cancer
-Prostate Cancer
-Skin Cancer
-Soft Tissue Sarcoma
-Stomach Cancer
-Thyroid Cancer
SS18L1 20q13.3 CREST, LP2261Somatic-Synovial Sarcoma
EEF1A2 20q13.3 HS1, STN, EF1A, STNL, EEF1AL, EF-1-alpha-2-Breast Cancer
-Ovarian Cancer
BIRC7 20q13.3 KIAP, LIVIN, MLIAP, RNF50, ML-IAP-Acute Lymphocytic Leukaemia (ALL)
-Bladder Cancer
-Eye Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
-Melanoma
-Prostate Cancer
PTK6 20q13.3 BRK-Breast Cancer
-Ovarian Cancer
-Prostate Cancer
CTCFL 20q13.31 CT27, BORIS, CTCF-T, HMGB1L1, dJ579F20.2-Breast Cancer
-Lung Cancer
-Ovarian Cancer
-Stomach Cancer
-Testicular Cancer
-Uterine Sarcoma
ADRM1 20q13.33 ARM1, ARM-1, GP110-Colorectal Cancer
-Ovarian Cancer
GATA5 20q13.33 GATAS, bB379O24.1-Colorectal Cancer
-Esophageal Cancer
-Kidney Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
-Ovarian Cancer
-Stomach Cancer

Structural Abnormalities

Selected list of common recurrent structural abnormalities - Chromosome 20:

Abnormality Type Gene(s)
t(20;22) EWSR1-NFATC2 in Ewing's SarcomaTranslocationNFATC2 (20q13.2)EWSR1 (22q12.2)
t(11;20) (p15;q11) NUP98-TOP1 Fusion in AMLTranslocationTOP1 (20q12-q13.1)NUP98 (11p15.5)
Occasional translocation of MAFB in MyelomaTranslocationMAFB (20q11.2-q13.1)

This is a highly selective list aiming to capture structural abnormalies which are frequesnt and/or significant in relation to diagnosis, prognosis, and/or characterising specific cancers. For a much more extensive list see the Mitelman Database of Chromosome Aberrations and Gene Fusions in Cancer.


Further Resources (2 links)

Further Resources


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Cite this page: Cotterill SJ. Chromosome 20, Cancer Genetics Web: http://www.cancerindex.org/geneweb/clinkc20.htm Accessed: date

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