Chromosome 20

Genes Linked with Cancer

How to use this data table Click on the gene name for detailed information. Type in the Search box e.g. 'germline' or 'Breast Cancer' to search within Chromosome 20; or Sort by clicking on a column heading e.g. 'Gene'.

Gene Location Aliases Abnormalities Implicated in
PCNA 20pter-p12 Somatic
PYGB 20p11.21 GPBB
-Thyroid Cancer
ASXL1 20q11 MDS, BOPSSomatic
NNAT 20q11.2-q12 Peg5
MMP9 20q11.2-q13.1 GELB, CLG4B, MMP-9, MANDP2
RBL1 20q11.2 PRB1, p107, CP107
E2F1 20q11.2 RBP3, E2F-1, RBAP1, RBBP3
MAFB 20q11.2-q13.1 KRML, MCTOSomatic
-Multiple Myeloma
TOP1 20q12-q13. TOPISomatic
SRC 20q12-q13 ASV, SRC1, c-SRC, p60-Src
CD40 20q12-q13.2 p50, Bp50, CDW40, TNFRSF5
SDC4 20q12 SYND4Somatic
MYBL2 20q13.1 BMYB, B-MYBOverexpression-Liver Cancer
NFATC2 20q13.2 NFAT1, NFATPSomatic
-Ewing's Sarcoma
ZNF217 20q13.2 ZABC1
TFAP2C 20q13.2 ERF1, TFAP2G, hAP-2g, AP2-GAMMA
BCAS1 20q13.2 AIBC1, NABC1
TNFRSF6B 20q13.3 M68, TR6, DCR3, M68E, DJ583P15.1.1Somatic
Many cancer types including:
-Bowel Cancer
-Liver Cancer
-Lung Cancer
-Pancreatic Cancer
-Stomach Cancer
SS18L1 20q13.3 CREST, LP2261Somatic
GNAS 20q13.3 AHO, GSA, GSP, POH, GPSA, NESP, GNAS1, PHP1A, PHP1B, PHP1C, C20orf45Somatic
ADRM1 20q13.33 ARM1, ARM-1, GP110

Structural Abnormalities

Selected list of common recurrent structural abnormalities - Chromosome 20:

Abnormality Type Gene(s)
t(20;22) EWSR1-NFATC2 in Ewing's SarcomaTranslocationNFATC2 (20q13.2)EWSR1 (22q12.2)
Occasional translocation of MAFB in MyelomaTranslocationMAFB (20q11.2-q13.1)

This is a highly selective list aiming to capture structural abnormalies which are frequesnt and/or significant in relation to diagnosis, prognosis, and/or characterising specific cancers. For a much more extensive list see the Mitelman Database of Chromosome Aberrations and Gene Fusions in Cancer.

Further Resources (2 links)


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