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Single nucleotide polymorphisms (SNPs)

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Single nucleotide polymorphisms (SNPs)

Single nucleotide polymorphisms, often called "snips," are common variations that occur in DNA. These subtle genetic differences in our genetic makeup may be associated with individual characteristics including predisposition to cancer and responce to chemotherapy. The collaborative "SNP Consortium" has been formed to identify and analyse snips and to investigate how these are involved in disease, this may help in the development of more effective and less toxic treatments.

Selected references

  • Collins A, et al. Genetic epidemiology of single-nucleotide polymorphisms Proc Natl Acad Sci USA. 1999 96(26), 15173-7

  • Woodman R Wellcome trust and drug giants fund gene marker database BMJ. 1999; 318(7191):1093    Related articles

  • Skibola CF, et al. Polymorphisms in the methylenetetrahydrofolate reductase gene are associated with susceptibility to acute leukemia in adults. Proc Natl Acad Sci USA. 1999; 96(22),12810-15    Related articles

  • Ma J, et al. Methylenetetrahydrofolate reductase polymorphism, dietary interactions, and risk of colorectal cancer. Cancer Res 1997; 57(6):1098-102    Related articles (PubMed)

  • Chen J, et al. A methylenetetrahydrofolate reductase polymorphism and the risk of colorectal cancer Cancer Res. 1996; 56(21):4862-4    Related articles (PubMed)

  • Medline Search: polymorphism[title] AND cancer (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

    Related topics

    See also Cancer Gene Web
    See also MTHFR gene
    See also Colorectal Cancer

    Topic last revised: 12/11/1999

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    This page last updated: Wed 14 May 2003 Home