-
 Cancer Genetics Web
 General Pathology / Molecular biology
- Units and Laboratories
- Molecular Biology Databases
- Single nucleotide polymorphisms (SNPs)
- Adenomatous Polyposis of the Colon; APC - Genetic information Physician's info. (OMIM, National Center for Biotechnology Information, USA)
- American Society for Biochemistry and Molecular Biology (ASBMB) (USA)
- ANGIOGEN - Angiogenesis Forum (ACOR) Email list
- Annual Review of Genetics
- Annual Review of Microbiology
- Association for Molecular Pathology (USA) A national organization, established to promote clinical practice, basic research, and education in molecular pathology. The Web site has details of membership, details of subdivisions - including the solid tumor group, meetings and announcements.
Bio-Web: Resources for Molecular and Cell Biologists The site aims to facilitate access to freely accessible resources for molecular and cell biologists. It includes, news, a links directory , extended sequence analysis tools, software, and biomail newsletters.
- Bladder Cancer - Genetic information (OMIM, National Center for Biotechnology Information, USA)
- Bone and Joint Pathology Images (WebPath, USA) Pathology Images - including Chondrosarcoma, Ewing's, and Osteosarcoma
- Brain Tumor Pathology Journal of the Japanese Society of Brain Tumor Pathology.
- Breasr Cancer associated DF3 antigen - Genetic Information (OMIM, National Center for Biotechnology Information, USA)
- Breast Cancer - Estrogen-Inducible Sequence BCE1 - Genetic Information (OMIM, National Center for Biotechnology Information, USA)
- Breast Cancer, 11;22 Translocation Associated - Genetic information (OMIM, National Center for Biotechnology Information, USA)
- Breast Cancer, Ductal, 1; BRCD1 - Genetic information (OMIM, National Center for Biotechnology Information, USA)
- Breast Cancer, Ductal, 2; BRCD2 - Genetic information (OMIM, National Center for Biotechnology Information, USA)
- Breast Cancer, Type 1 BRCA1 - Genetic information (OMIM, National Center for Biotechnology Information, USA)
- Breast Cancer-Related Regulator of TP53; BCPR - Genetic information (OMIM, National Center for Biotechnology Information, USA)
- Breast Pathology (WebPath, USA) Pathology Images - including some cancer related.
- Cancer - Genetic information (OMIM, National Center for Biotechnology Information, USA)
- Cancer Cytopathology A journal of the American Cancer Society
- Cancer of Colon - Genetic Information (USA) A referenced statement from the OMIM database, produced by the National Center for Biotechnology Information.
- Cancer of Lung - Genetic information (OMIM, National Center for Biotechnology Information, USA)
- Cancer of the Breast, Familial; BCS - Genetic information (OMIM, National Center for Biotechnology Information, USA)
- Cancer, Familial, with in vitro Radioresistance - Genetic information (OMIM, National Center for Biotechnology Information, USA)
- Cancer, Hepatocellular - Genetic information (OMIM, National Center for Biotechnology Information, USA)
- Cell Growth and Differentiation A journal of the American Association for Cancer Research. Table of Contents, Editorial board, instructions to authors etc.
- Central Nervous System Pathology (WebPath, USA) Pathology Images - including some cancer related.
- CGAP Genetic Annotation Initiative (National Cancer Institute, USA) a programme to identify and characterise genetic variation in genes important in cancer.
- Colon Cancer, Familial, Nonpolyposis Type 1; FCC1 - Genetic information Physician's info. (OMIM, National Center for Biotechnology Information, USA)
- Colon Cancer, Familial, Nonpolyposis Type 2 - Genetic information Physician's info. (OMIM, National Center for Biotechnology Information, USA)
- Colorectal Cancer-Related Chromosome Sequence-17; CRCR2; CRC17 - Genetic information Physician's info. (OMIM, National Center for Biotechnology Information, USA)
- Cumulative Survey of Histological and Cytological Findings 1989-1996 (Institute of Radiotherapy and Oncology, Medical Faculty Skopje, Macedonia) Download ZIP file an electronic book (887 pages) containing 55,000 aspiration biopsy findings and 90,000 histopathological findings, classified in several strata.
- Deleted in Colorectal Carcinoma; DCC - Genetic information Physician's info. (OMIM, National Center for Biotechnology Information, USA)
- Diagnostic Molecular Pathology (Journal)
- Dissemination of Breast Cancers - Dissemination des Cancers du Sein (By Marc Lacroix, Belgium) Includes information in both English and French. An overview of basic research into metastases in breast cancer with references and abstracts.
- Esophageal Cancer - Genetic Information (OMIM, National Center for Biotechnology Information, USA)
- Gastric Cancer - Genetic information (OMIM, National Center for Biotechnology Information, USA)
- Genes and Development (Journal)
- Genetic Interest Group (GIG) (UK) a national alliance of organisations and individual members providing support, promoting awarness and providing advocacy for people affected by genetic disorders. The Web site includes details of publications and guidelines, UK services, links etc.
- Genetics of Cancer Website (Robert H. Lurie Cancer Center, Northwestern University Medical School, USA) The web site has resources for the public, physicians and researchers. There is an open news group, case histories, and detailed information on cancer genetics.
- GYN Net - Pathology site Includes online database of breast and ceverical lesions (English and French language)
- Histology Atlas (University of Wisconsin Medical School, USA) A large general histology resource for medical students and health professionals. It includes online slides and references to cancer.
- Histology Guides from Vanderbilt University Medical Center (USA) Guides to blood, epithelium, peripheral nervous tissue, salivary gland, and exocrine pancreas
- Human Gene Mutation Database - Institute of Medical Genetics, Cardiff (UK) Search the HGDB which aims to collate known (published) gene lesions responsible for human inherited diseases.
- IARC Unit of Genetic Cancer Susceptibility (International Agency for Research on Cancer) Details of research and selected publications.
- IARC Unit of Genetic Epidemiology (International Agency for Research on Cancer) Details of research and selected publications.
- IARC Unit of Molecular Pathology (International Agency for Research on Cancer) Details of research and selected publications.
- International Journal of Biological Markers (Journal) - Browse articles in Medline
- Internet for the Molecular Biologist - introduction and useful sites
- Internet Resources for Pathology and Laboratory Medicine A useful index site - including some cancer links
- Journal of Biological Chemistry Journal of the American Society for Biochemistry and Molecular Biology.
- Keratosis Palmaris ET Plantaris with Esophageal Cancer - Genetic information (OMIM, National Center for Biotechnology Information, USA)
- Laboratory of Pathology - NCI Division of Clinical Sciences The Web site includes details of the clinical services, research, training and developmental molecular diagnostic operations of the laboratory.
- Leukemia, Acute Myelocytic, with Polyposis Coli and Colon Cancer - Genetic information (OMIM, National Center for Biotechnology Information, USA)
- Liver Cancer Oncogene; LCO - Genetic information (OMIM, National Center for Biotechnology Information, USA)
- LRF Immunodiagnostics Unit (University of Oxford, UK)
- Madison Research Group (USA) a private corporation devoted to the study of osteosarcoma, particularly molecular biology. The web site includes information about treatment, incidence, molecular biology and glossary.
- Medical PET Group - Biological Imaging (German Cancer Research Center)
- Meta Index of Pathology Lists (Hardin Meta Directory of Internet Health Sources)
- Micro and Cellular Biology a journal of the American Society for Microbiology
- Molecular Biology Techniques Forum "a professional forum for reader-submitted techniques, tips and questions concerning molecular biology."
- Molecular Carcinogenesis (Journal)
- Molecular Diagnosis (Journal) a interdisciplinary journal covering molecular diagnostics in patient management including inherited , infectious, and neoplastic diseases.
- Molecular Research in Pediatric CNS Tumors (Childhood Brain Tumor Foundation) by Philip Cogen
- Multimedia Learning - disease, anatomy, and other interactive teaching material. (Levit Radiologic-Pathologic Institute, Texas, USA)
- Nasopharyngeal Cancer - Genetic information (OMIM, National Center for Biotechnology Information, USA)
- On-line Medelian Inheritance In Man (OMIM) - Search for articles (OMIM, National Center for Biotechnology Information, USA)
- Online Mendelian Inheritance in Man (OMIM) -UK mirror (MRC, UK) data base of human genes and genetic disorders
- OPHTHALMO Web - Pathology site Includes access to an online database of orbital eye lesions (English and French Language)
- Ovarian Tumor - Genetic information (OMIM, National Center for Biotechnology Information, USA)
- Pancreatic Carcinoma - Genetic information (OMIM, National Center for Biotechnology Information, USA)
- Patho.Wat.CH A Swiss pathology site including may useful links
- Pathology Manual: Gynecologic Oncology Group (Virtual Hospital) Editor: Jo Ann Benda, MD. The site includes pages about histological classification of a wide range of gynecologic cancers.
- Pathology Oncology Research Journal of the Aranyi Lajos Foundation
- Pathology Teaching Materials (University of Kansas Med Center, USA) This is a general pathology site which includes many cancer related resources.
- Primer on Molecular Genetics (USA) a report by Denise Casey, Department of Energy
- Prostate Cancer; PRCA1 - Genetic information (OMIM, National Center for Biotechnology Information, USA)
- Renal Cell Carcinoma - Genetic information (OMIM, National Center for Biotechnology Information, USA)
- sci.med.pathology News Group
- Seminars in Cancer Biology (Journal) as part of the IDEAL scheme the journal has free tables of contents with abstracts for all users and full text PDF files for registered users,
- Society for Pediatric Pathology
- Solid Tumor Interest Group of the Association for Molecular Pathology
- Testicular Tumors - Genetic information (OMIM, National Center for Biotechnology Information, USA)
- The Dictionary of Cell Biology - On-line Edition (Institute for Biomedical and )The dictionary contains over 5,000 cross-referenced entries. The dictionary has a graphical interface and search facilities. Editors - Julian Dow and John Lackie.
- Thyroid Carcinoma, Papillary - Genetic Information (OMIM, National Center for Biotechnology Information, USA)
- Tumor Board A free site including a large library of pathology images.
- Tumor Gene Database (Baylor College of Medicine)
- UK Human Genome Mapping Project Resource Centre (MRC, UK) includes a mirrors / links to many human and animal genome databases including GDB, SRS, and OMIM.
- Understanding a Biopsy Report by Dr. Ed Uthman (Cancerguide)
- Universal APC Database (Universal Mutation Database) Large referenced database by Christophe Béroud and Thierry Soussi, Institute Curie, France
- University of Pennsylvania Center for Bioethics
- Update on Non-Hodgkin's Lymphoma, and Lymphoma Classification by Laura L. Schmitz, MD, Pathologist, North Memorial Health Care
- Urbana Atlas of Pathology (University of Illinois College of Medicine, USA) Includes many cancer related images and texts.
- Ureter Cancer - Genetic information (OMIM, National Center for Biotechnology Information, USA)
- WebPath - InterNet Pathology Laboratory for Medical Education LOTS of medical images
See also Resources by Disease Type
See also genetics / cytogenetics / cytokines
- Abbott Northwestern Hospital Cancer Research Laboratory (Minneapolis, USA)
- Cancer Research UK - Beatson Laboratories (Glasgow, UK)
- Cold Spring Harbor Laboratory (New York) The Laboratory was created in 1890 and its programs focus on cancer, neurobiology and plant genetics. It is a NCI designated Cancer Center. The Web site includes details of research and educational resources.
- Jackson Laboratory (Bar Harbor, Maine, USA) a NCI designated Cancer Center. The Jackson Laboratory is an independent non-profit mammalian research laboratory.
- McArdle Laboratory for Cancer Research (University of Wisconsin, Madison) The Laboratory and Department of Oncology were founded in 1940. The Web site includes details of basic research programs and laboratories.
- MIT, Cancer Research Laboratory of Prof. David E. Housman (USA)
- National Foundation for Cancer Research (USA) The NFCR was founded in 1973 to support laboratory based basic science research. The site includes detailed information on research projects, cancer prevention, treatment, FAQs, contact information etc.
- Salk Institute- Cancer Research Center (La Jolla, CA) a NCI designated Cancer Center
- UNMC Eppley Cancer Center (University of Nebraska Medical Center, Omaha, USA) A NCI designated Cancer Center. The Web site includes details of research programs and patient services.
- Wood Hudson Cancer Research Lab (Newport, Kentucky, USA)
********** Information for Health Professionals ***********
- Brain Tumor Biology Laboratory, Henry Ford Hospital, Detroit (USA) These pages include details of the labs research, extensive pages on the scientific background of brain tumours, lab protocols, project details, staff, publications, brain tumour and scientific links.
- Department of Tumor Biology, MD Anderson Cancer Center (USA) Includes resources, directories, education, and faculty information.
- Division of Molecular and Clinical Immunology, University of Nottingham. (UK)
- European Bioinformatics Institute (Cambridge, UK) includes databases of nucelotide and protein sequences, similarity searches and other services.
- ICRF Groups at the Institute for Molecular Medicine (Oxford, UK)
- ISREC: Swiss Institute for Experimental Cancer Research (Lausanne, Switzerland) research into the "detection and assessment of similarity between distantly related protein and DNA sequences by means of Generalized Profiles." Details of methods, profiles, and software.
- Laboratory of Immunobiology - National Cancer Institute (USA) This is part of the NCI Division of Basic Sciences. It is composed of a Cellular Immunity Section which studies the pathogenesis of renal cancers and an Immunopathology Section which studies proteins that mediate the response to infection or injury
- Lawrence Berkeley National Laboratory -Resource for Molecular Cytogenetics (Lawrence Berkeley National Laboratory and the University of California, USA) Includes research resources about FISH, Probe Mapping Data, Images. Funded by the US Department of Energy
- Leukaemia Research Fund - Molecular Pharmacology Programme (Newcastle University, UK) research in the lab aims to improve targeting of cytotoxic drugs in the treatment of leukaemia. The web pages contain an overview of the research, list of personnel, contact information etc.
- Levit Radiologic-Pathologic Institute (University of Texas MD Anderson Cancer Center, USA)
- M. D. Anderson Cancer Center - Section of Neuropathology (University of Texas, USA)
- Neuroblastoma Laboratory - Philipps University - Marburg (Germany) The site includes information about neuroblastoma, details about the research unit, staff details, publications etc. English language.
- Northern Institute for Cancer Research (Newcastle University, UK)
- Nuclear Structure and Function Research Group (Oxford University, UK)
- Tumor Angiogenesis Laboratory (University Hospital of Maastricht, Netherlands) both Dutch and English language pages.
- Tumor Immunology Laboratory (University Hospital Nijmegen St Radboud, Netherlands)
- University of Cambridge - Department of Pathology (UK)
See also Cancer Centres and Institutes
- Breast Cancer Information Core An on-line breast cancer mutation database. This is an international collaboration hosted by the NIH National Human Genome Research Institute. The Web site includes the database (requires registration), laboratory methods, forum and resources.
- Charite - Online CGH Tumor Database (University Hospital Charite, University of Berlin, Germany) this interactive database was established in April 1999 and allows online viewing of CGH images for various tumor collections.
********** Information for Health Professionals ***********
- American Type Culture Collection (ATCC) (USA) This site includes the NCI Human Tumor Cell Lines database and Hybridoma Data Bank.
- Androgen Receptor Gene Mutations Database (McGill University, Montreal, Canada) a database of AR mutations, map of AR interacting proteins, mutations map for prostate cancer, online forum and links.
- Atlas of Genetics and Cytogenetics in Oncology and Haematology (Poitiers University, France) a collaborative site made for and by cytogeneticists, molecular biologists, oncologists etc. Databases of genes, cytogenetic abnormalities, disease types, and cancer prone conditions. English and French language.
- BCM Search Launcher - Baylor College of Medicine (USA) This site provides a single point-of-entry for sequence searches accross molecular biology-related search and analysis services available on the WWW. Searches include multiple and pairwize sequence alignments.
- Cancer Genome Anatomy Project (National Cancer Institute, USA) CGAP is an interdisciplinary program to establish the information and technological tools needed to decipher the molecular anatomy of the cancer cell. resources for genes, breakpoints etc.
- Cancer Genome Anatomy Project / Database (National Cancer Institute + partners) aims to establish complete index of genes expressed in tumors. A growing database sorted by anatomical site, from which gene sequences can be downloaded. It includes details of reagents and methodology.
- Comparative Genomic Hybridization Literature Database (National Human Genome Research Institute, USA)
- Cytokine Family cDNA Database (dbCFC) (Kumamoto University, Japan)
- Database of Single Nucleotide Polymorphisms (National Center for Biotechnology Information) A public database of single base nucleotide substitutions and short deletion and insertion polymorphisms. Users can search for and submitt SNPs.
- European Molecular Biology Network - Belgian node
- European Molecular Biology Network - Irish node (Irish National Centre for BioInformatics)
- European Molecular Biology Network - Norway node (Norway)
- European Molecular Biology Network - Swiss node (ISREC/University of Geneva, Switzerland)
- Fanconi Anemia Mutation Database An international collaborative database co-ordinated by Rockefeller University (USA) and Guy's Hospital (UK). The site includes public and private databases, reference sequences and related links.
- GDB - Genome Database (Human Genome Project) database of the international collaborative project established in 1990.
- GeneMap'98 (Genome Project) a new online 'gene map' pinpointing the chromosomal locations of almost half of human genes. Produced by a team of 64 scientists from government, university and commercial organisations from around the world.
- Hereditary Non-Polyposis Colorectal Cancer - Mutation Databases (International Collaborative Group on Hereditary Non-Polyposis Colorectal Cancer) includes databases of MLH1, MSH2, MSH6, PMS1 and PMS2 mutations.
- HGBASE - Human Genetic Bi-Allelic SEquences (Karolinska Institute - Sweden and Interactiva Biotechnologie - Gernamy) database of single nucleotide polymorphisms
- HistoBank - Interactive Histology Atlas (National Institutes of Health, USA) a database to view and submit human and animal histopathology images including entries for cancerous tissues.
- Human Gene Mutation Database - Institute of Medical Genetics, Cardiff (UK) Search the HGDB which aims to collate known (published) gene lesions responsible for human inherited diseases.
- Human Genome Mapping Project Resource Centre / European Molecular Biology Network (Cambridge, UK) a Medical Research Council centre and also a national node of the European Molecular Biology Network. The site offers access to all major molecular biology sequence and structure databases.
- IARC database of Somatic P53 Mutations in Human Tumours and Cell Lines (IARC) Web interface or download.
- Kyoto Encyclopedia of Genes and Genomes (GenomeNet) (Kyoto University, Japan) Includes chemical database for enzyme reactions, biomolecular relations in information transmission and expression, and listing of genomes.
- Mouse Tumor Biology Databases (MTB) This is database is maintained by the Jackson Laboratory and is funded by the NCI. Data is available by tumour and tissue type, with information on pathology and mice strains to facilitate the mouse as a model system of hereditary cancer.
- Neal's DNA Mutation Site - Database (USA) Databases and software for the analysis of mutations (lacl, p53, hprt, lacZ)
- Nomenclature Nomenclature database of the HUGO Nomenclature Committee
- Online Mendelian Inheritance in Man (OMIM) (National Center for Biotechnology Information, USA) a searchable database which catalogues human genes and genetic disorders with links to Medline Citations.
- Ribosomal Database Project (University of Illinois at Urbana-Champaign, USA) LSU and SSU databases, analysis software etc.
- Sanger Centre, The (Cambridge, UK) a genome research centre set up in 1992 by the Wellcome Trust and the Medical Research Council. Includes access to a range of gene databases.
- Tumor Gene Database (Baylor College of Medicine)
- Tumour Atlas and Knowlege Base (Frontiers in Bioscience) includes lots of tumour pathology images and information
- Unigene (National Center for Biotechnology Information, USA)
- Universal APC Database (Universal Mutation Database) Large referenced database by Christophe Béroud and Thierry Soussi, Institute Curie, France
- Universal Mutation Database (INSERM) French Institute of Health and Medical Research
See also Journals
See also Medline
Single nucleotide polymorphisms, often called "snips," are common variations that occur in DNA. These subtle genetic differences in our genetic makeup may be associated with individual characteristics including predisposition to cancer and responce to
chemotherapy. The collaborative "SNP Consortium" has been formed to identify and analyse snips and to investigate how these are involved in disease, this may help in the development of more effective and less toxic treatments.
Selected references
Collins A, et al. Genetic epidemiology of single-nucleotide polymorphisms Proc Natl Acad Sci USA. 1999 96(26), 15173-7
Woodman R Wellcome trust and drug giants fund gene marker database BMJ. 1999; 318(7191):1093 Related articles
Skibola CF, et al. Polymorphisms in the methylenetetrahydrofolate reductase gene are associated with susceptibility to acute leukemia in adults. Proc Natl Acad Sci USA. 1999; 96(22),12810-15 Related articles
Ma J, et al. Methylenetetrahydrofolate reductase polymorphism, dietary interactions, and risk of colorectal cancer. Cancer Res 1997; 57(6):1098-102 Related articles (PubMed)
Chen J, et al. A methylenetetrahydrofolate reductase polymorphism and the risk of colorectal cancer Cancer Res. 1996; 56(21):4862-4 Related articles (PubMed)
Medline Search: polymorphism[title] AND cancer (PubMed)
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Related topics
See also Cancer Gene Web
See also MTHFR gene
See also Colorectal Cancer
Topic last revised: 12/11/1999
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