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  Chondrosarcoma

Mutated Genes and Abnormal Protein Expression (11)
Recurrent Chromosome Abnormalities (2)
Overview of Chondrosarcoma Genetics
Chondrosarcoma: Clinical and Epidemiological Resources
  Mutated Genes and Abnormal Protein Expression
GeneLocationTopics
EXT18q24.11-q24.13 -EXT1 and Secondary Chondrosarcoma
MYC ( CMYC , C-MYC ) 8q24.12-q24.13 -MYC and Chondrosarcoma
NR4A3 ( CHN , CSMF , NOR1 ) 9q22 -t(9;22)(q22;q12) in Extraskeletal Myxoid Chondrosarcoma
-t(9;17)(q22;q11) in Extraskeletal Myxoid Chondrosarcoma
EXT211p12-p11 -EXT2 and Secondary Chondrosarcoma ?
MMP1 ( CLG ) 11q22-q23 -MMP1 and Chondrosarcoma
MMP14 ( MT1-MMP ) 14q11-q12 -MMP14 and Chondrosarcoma
MMP2 ( CLG4A , CLG4 , GELA ) 16q13 -MMP2 and Chondrosarcoma
TIMP217q25 -TIMP2 and Chondrosarcoma
EXT319p -EXT3 and Secondary Chondrosarcoma ?
MMP9 ( CLG4B ) 20q11.2-q13.1 -MMP9 and Chondrosarcoma
TIMP1 ( EPO , CLGI , TIMP ) Xp11.3-p11.23 -TIMP1 and Chondrosarcoma

 

  Recurrent Chromosome Abnormalities

t(9;22)(q22;q12) in Extraskeletal Myxoid Chondrosarcoma
t(9;17)(q22;q11) in Extraskeletal Myxoid Chondrosarcoma
  Overview of Chondrosarcoma Genetics

  • Bovee JV, et al. Loss of heterozygosity and DNA ploidy point to a diverging genetic mechanism in the origin of peripheral and central chondrosarcoma. Genes Chromosomes Cancer 1999; 26(3):237-246    Related articles (PubMed)

  • Toriyama M, et al. Matrix metalloproteinase digestion of aggrecan in human cartilage tumours. Eur J Cancer 1998;34(12):1969-73    Related articles (PubMed)

    Chondrosarcoma Genetics
    Chondrosarcoma : Clinical and Epidemiological Information

     

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