|Population in 2012:||11.4m|
|People newly diagnosed with cancer (excluding NMSC) / yr:||41,000|
|Age-standardised rate, incidence per 100,000 people/yr:||163.0|
|Risk of getting cancer before age 75:||16.0%|
|People dying from cancer /yr:||28,500|
Greece: Cancer Journals
Latest Research Publications from Greece
Greece: Cancer Organisations and Resources (5 links)
Ελληνική Αντικαρκινική Εταιρεία | Hellenic Cancer Society - ελληνικά - Translate to English
A non-profit organization, founded in 1958 to fight of cancer and provide information on cancer and prevention.
Ελληνική Συνεργαζόμενη Ογκολογική Ομάδα | Hellenic Cooperative Oncology Group - ελληνικά - English
A non-profit scientific organisation of leading physicians and other scientists, members of the Medical Oncologic community in Greece. Founded 1990.
Εταιρεία Ογκολόγων Παθολόγων Ελλάδας | Hellenic Society of Medical Oncology - ελληνικά - English
HeSMo was founded in 1986to promote the exchange of current information and ideas relating to clinical research, prevention, diagnosis and treatment of cancer + continuing education for oncologists in Greece.
ΙΔΡΥΜΑ ΔΡΑΣΗΣ ΚΑΤΑ ΤΟΥ ΚΑΡΚΙΝΟΥ ΤΟΥ ΜΑΣΤΟΥ | Breast Cancer Action Fund - ελληνικά - English
A nonprofit organisation, with humanitarian and social support of breast cancer and scientific research. Founded 2007.
Greece: Cancer Journals (3 links)
Peer-reviewed journal for articles and reviews on the application of genomic and proteomic technology to basic, experimental and clinical cancer research. A journal of the International Institute of Anticancer Research. From January 2013 CGP is converted to an online-only open access journal.
FCO is an open-access peer-reviewed quarterly publication of the Hellenic Society of Medical Oncology.
Gastric Breast Cancer Editorial Office
Provides secondary-research articles (editorials, perspectives, news/views etc) on best practice and future clinical and research directions prevention and early detection, multidisciplinary, evidence-based management and treatment of breast cancer and gastric cancer. International editorial board, peer reviewed and open access.
Latest Research Publications from Greece
Gene-Specific Intron Retention Serves as Molecular Signature that Distinguishes Melanoma from Non-Melanoma Cancer Cells in Greek Patients.
Int J Mol Sci. 2019; 20(4) [PubMed] Free Access to Full Article Related Publications
METHODS: Intron retention events were examined through RT-sqPCR protocols, using total RNA preparations derived from BCC, SCC, and melanoma Greek biopsy specimens. Intron-hosted miRNA species and their target transcripts were predicted via the miRbase and miRDB bioinformatics platforms, respectively. Ιntronic ORFs were recognized through the ORF Finder application. Generation and visualization of protein interactomes were achieved by the IntAct and Cytoscape softwares, while tertiary protein structures were produced by using the I-TASSER online server.
TNFAIP3 F127C Coding Variation in Greek Primary Sjogren's Syndrome Patients.
J Immunol Res. 2018; 2018:6923213 [PubMed] Free Access to Full Article Related Publications
Epidemiological characteristics, clinical outcomes and management patterns of metastatic breast cancer patients in routine clinical care settings of Greece: Results from the EMERGE multicenter retrospective chart review study.
BMC Cancer. 2019; 19(1):88 [PubMed] Free Access to Full Article Related Publications
METHODS: "EMERGE" was a multicenter, retrospective cohort study of adult MBC patients diagnosed between 01-Janaury-2010 and 30-June-2012, either de novo or having progressed from a non-metastatic state. Patient data, including treatment patterns and outcomes, were mainly abstracted through medical chart review.
RESULTS: 386 patients were enrolled by 16 hospital-based oncologists between 12-March-2013 and 31-March-2015. The median look-back period was 29.1 months. At MBC diagnosis, 56.1% of the patients were HR
CONCLUSIONS: "EMERGE" demonstrates differences between HR/HER2 subtypes in clinical outcomes and divergence from evidence-based guideline recommendations for MBC management, especially as it pertains to the HR
STUDY REGISTRATION: The study has been registered on the electronic Registry of Non-Interventional Studies (RNIS) posted on the website of the Hellenic Association of Pharmaceutical Companies (SFEE): https://www.dilon.sfee.gr/studiesp_d.php?meleti_id=NIS-OGR-XXX-2012/1.
Management of uterine sarcomas and prognostic indicators: real world data from a single-institution.
BMC Cancer. 2018; 18(1):1247 [PubMed] Free Access to Full Article Related Publications
METHODS: We retrospectively analyzed all female patients with uterine sarcomas treated in our institution over the last 17 years. Clinico-pathological data, treatments and outcomes were recorded. Kaplan-Meier curves were plotted and time-to-event analyses were estimated using Cox regression.
RESULTS: Data were retrieved from 61 women with a median age of 53 (range: 27-78) years, at diagnosis. Fifty-one patients were diagnosed with leiomyosarcoma (LMS), 3 with high grade endometrial stromal sarcoma (ESS), 5 with undifferentiated uterine sarcoma (UUS), 1 with Ewing sarcoma (ES) and 1 with Rhabdomyosarcoma (RS). 24 cases had stage I, 7 stage II, 14 stage III and 16 stage IV disease. Median disease-free survival (DFS) in adjuvant approach was 18.83 months, and median overall survival (OS) 31.07 months. High mitotic count (> 15 mitoses) was significantly associated with worse OS (P < 0.001) and worse DFS (P = 0.028).
CONCLUSIONS: Mitotic count appears to be independent prognostic factor while further insights are needed to improve adjuvant and palliative treatment of uterine sarcomas.
Patterns of practice and pharmacoeconomic analysis of the management of patients with metastatic renal cell carcinoma (mRCC) in Greece--the CRISIS study. A retrospective analysis by the Hellenic Genitourinary Cancer Group (HGUCG).
Expert Rev Pharmacoecon Outcomes Res. 2019; 19(4):491-501 [PubMed] Related Publications
Giant nonfunctioning adrenal tumors: two case reports and review of the literature.
J Med Case Rep. 2018; 12(1):335 [PubMed] Free Access to Full Article Related Publications
CASE PRESENTATION: The first case report describes a 39-year-old Greek woman who presented to our department with complaints of repeated symptoms of flatulence and epigastric discomfort over a few months. The second case report is about a 67-year-old Greek woman who presented to our department after being evaluated for fatigue, mass effect, and epigastric discomfort. Both of them were diagnosed as having a nonfunctioning adrenocortical carcinoma and underwent open adrenalectomy.
CONCLUSIONS: Approximately 60% of patients with adrenocortical carcinoma present with symptoms and signs of hormonal secretion. Our cases' adrenocortical carcinomas were not functional. Hormone secretion is not a discriminating feature between benign and malignant adrenocortical masses. The silent clinical nature of nonfunctioning adrenocortical carcinoma results in late diagnosis, while the majority of patients present with locally advanced and/or metastatic disease. Adrenocortical carcinoma is a rare endocrine tumor with a poor prognosis that can be diagnostically challenging and demands high clinical suspicion. The work-up for adrenal masses must include determination of whether the mass is functioning or nonfunctioning and whether it is benign or malignant.
Dermal Lesions and Skin Cancer in Patients with Inflammatory Bowel Disease Receiving Immunosuppressive Therapy
Asian Pac J Cancer Prev. 2018; 19(10):2845-2851 [PubMed] Free Access to Full Article Related Publications
Polymorphic variability in the exon 19 of the RB1 gene and its flanking intronic sequences in HPV16-associated precancerous lesions in the Greek population.
J Med Microbiol. 2018; 67(11):1638-1644 [PubMed] Related Publications
METHODOLOGY: The nucleotide polymorphism A153104G was detected by PCR-RFLP assay, while the amplicons were further subjected to cloning and sequencing. Moreover, molecular evolutionary analysis was performed using the maximum-likelihood (ML) and empirical Bayesian (EB) methods in order to evaluate the selective pressure acting on exon 19 of the RB1 gene.Results/Key findings. The A153104G nucleotide polymorphism was only detected in one control case. Moreover, sequence analysis of the amplicons revealed that the polymorphic variability in the RB1 gene increased with the severity of the cervical dysplasia. The link between the observed polymorphic variability and the progress of cervical disease was reflected in the molecular evolutionary analysis that was performed on the exon 19 of the RB1 gene, since negative selective pressure was acting upon exon 19 in the control and low-grade squamous intraepithelial lesion (LSIL) cervical samples, while positive selective pressure was acting upon exon 19 in the high-grade squamous intraepithelial lesion (HSIL) specimens.
CONCLUSIONS: The A153104G nucleotide polymorphism did not emerge as a potential biomarker for the development of precancerous lesions in the Greek patients, while the accumulation of sequence variations in RB1 gene might influence patients' susceptibility towards the progression of cervical neoplasia.
ABO blood group and the risk of lung cancer in Greek adults: a case - control study.
Exp Oncol. 2018; 40(3):249-250 [PubMed] Related Publications
MATERIALS AND METHODS: The study was conducted on 122 lung cancer patients and 1,255 matched-healthy individuals that were reviewed retrospectively. Chi-square and logistic regression models were used for statistical analysis.
RESULTS: No significant difference between lung cancer patients and the control group was recorded regarding ABO blood types and the risk of lung cancer (p = 0.055, OR = 0.79, 95% CI 0.61-1.03). Male gender (p = 0.006, OR = 2.08, 95% CI 1.24-3.49) and smoking (p = 0.000, OR = 3.13, 95% CI 1.72-5.69) were significantly associated with the risk of lung cancer.
CONCLUSION: No association between ABO blood types and the risk of lung cancer was observed.
Does proximity to the subventricular zone and expression of CXCR-4 and nestin affect prognosis in high-grade glioma?
Br J Neurosurg. 2018; 32(6):614-618 [PubMed] Related Publications
METHOD: All patients diagnosed with high-grade glioma over a three-year period from a single institution were enrolled in this prospective study. Based on MRI preoperative findings, the patients were classified into 4 Groups (I-IV) according to the proximity of the CEL on MRI to the SVZ. Histological samples were assessed with immunohistochemistry for nestin and CXCR4. Classification into groups and the presence of nestin and CXCR4 were evaluated as predictive factors for overall (OS) and progression free survival (PFS).
RESULTS: Fourty patients were included in the study. In multivariate analysis, Groups II, III and IV predicted longer OS in comparison to group I (p = 0.01; p < 0.01; p < 0.01 respectively) and group III and IV predicted longer OS in comparison to group II (p < 0.01; p = 0.04 respectively). Group III predicted longer PFS than group I and II (p = 0.01; p < 0.01 respectively). The expression rates of CXCR-4 and nestin could not predict OS or PFS.
CONCLUSIONS: In our study the classification according to the proximity of the contrast enhancing part of the lesion and the SVZ proved to be prognostically significant for both OS and PFS. Presence of CXCR4 or nestin was not predictive for OS or PFS.
Contribution of RAD51D germline mutations in breast and ovarian cancer in Greece.
J Hum Genet. 2018; 63(11):1149-1158 [PubMed] Related Publications
The distinguished Greek born, French ophthalmologist Photinos Panas (1832-1903) and his views on ocular cancer.
J BUON. 2018 May-Jun; 23(3):842-845 [PubMed] Related Publications
Breast self-examination in Greek midwives and midwifery students.
Neoplasma. 2018; 65(6):980-985 [PubMed] Related Publications
Assessment of Depression and Anxiety in Breast Cancer Patients: Prevalence and Associated Factors
Asian Pac J Cancer Prev. 2018; 19(6):1661-1669 [PubMed] Free Access to Full Article Related Publications
Anticancer Res. 2018; 38(6):3735-3744 [PubMed] Related Publications
PATIENTS AND METHODS: REASON (NCT01153399) was a prospective study of patients with stage IIIB/IV NSCLC and known EGFR mutation status. Clinicopathological, treatment characteristics and clinical outcomes were recorded and correlated with EGFR mutation testing results.
RESULTS: Of 575 enrolled patients, EGFR mutations were detected in 15.7% of them. Male gender (p=0.008) and smoking (p<0.001), but not adenocarcinoma, were associated with EGFR M+ status. In the EGFR M+ subpopulation (n=88), absence of bone and/or brain metastasis and presence of exon 19 EGFR M+ status at diagnosis were independently associated with longer progression-free survival (PFS) (p=0.011 and p=0.040, respectively).
CONCLUSION: In our population, males and smokers had decreased odds of harboring an EGFR mutation, while adenocarcinoma histology was not a significant predictor of EGFR M+ status. EGFR M+ patients with bone and/or brain metastases at diagnosis or mutations other than exon 19 deletions were at increased risk for earlier disease progression.
Hyaluronic acid and hyaluronidase as possible novel urine biomarkers for the diagnosis of prostate cancer.
Med Oncol. 2018; 35(7):97 [PubMed] Related Publications
Characterization and prevalence of two novel CHEK2 large deletions in Greek breast cancer patients.
J Hum Genet. 2018; 63(8):877-886 [PubMed] Related Publications
CDKN2A/CDK4 Status in Greek Patients with Familial Melanoma and Association with Clinico-epidemiological Parameters.
Acta Derm Venereol. 2018; 98(9):862-866 [PubMed] Free Access to Full Article Related Publications
Reliability and validity of the Eating Assessment Tool-10 (Greek adaptation) in neurogenic and head and neck cancer-related oropharyngeal dysphagia.
Eur Arch Otorhinolaryngol. 2018; 275(7):1861-1868 [PubMed] Related Publications
METHODS: The study consisted of: item generation in the Greek language, internal consistency and reliability analysis, normative data generation, and validity analysis. Data were collected prospectively from 421 participants: 144 asymptomatic subjects, 146 patients with dysphagia, and 131 patients with dysphagia-related diagnoses. Validity was assessed by comparing scores of healthy and dysphagic participants, by comparing pre- and post-treatment scores, and by correlating the Greek-EAT-10 with fibreoptic endoscopic evaluation of swallowing (FEES).
RESULTS: The mean participants' age was 52.85 years (ranging from 18 to 85 years). All questionnaires were completed in less than 3 min. The overall internal consistency (assessed with Cronbach's alpha) was 0.963. The test-retest reliability was excellent with Spearman's rho ranging from 0.937 to 1. Dysphagic patients had a significantly higher score compared to healthy participants (p < 0.001). The mean EAT-10 improved significantly after treatment (Wilcoxon signed rank, p < 0.001). The Greek-EAT-10 and FEES scores were significantly correlated (Spearman's rho = 0.69).
CONCLUSIONS: The EAT-10 is a valid, reliable, symptom-specific tool for the assessment of dysphagia, easily self-administered, and practical for clinical use.
Quality assurance protocol for superficial and deep hyperthermia systems established by the Hellenic Association of Medical Physicists (HAMP) in cooperation with the Hellenic Society of Oncologic Hyperthemia (HSOH): A study based on European Society for Hyperthermic Oncology (ESHO) quality assurance guidelines.
J BUON. 2018 Mar-Apr; 23(2):494-499 [PubMed] Related Publications
METHODS: A working group was created by the Hellenic Association of Medical Physicists (HAMP) for the proposal of QA guidelines for superficial and deep hyperthermia systems. A review of the protocol proposed by ESHO, together with the existing protocols in other European and International centers, as well as protocols suggested by European or International organizations, was performed. Then, a protocol was suggested, describing procedures for QA according to the current technology and the existing equipment used in Greece.
RESULTS: A protocol describing the procedures for QA of superficial and deep hyperthermia systems was proposed. These procedures aim to evaluate the correct operation of the device, the thermometric system, the generator, the incorporated power meter and the applicators. It will also ensure the electrical safety of the devices.
CONCLUSIONS: The proposed protocol, applied by medical physicists in Greece, will ensure an efficient treatment with safety and minimum adverse effects. This protocol has been approved by the Hellenic Society of Oncologic Hyperthermia and the Hellenic Association of Medical Physicists.
Quality of life after cytoreductive surgery and HIPEC: A single centre prospective study.
J BUON. 2018 Mar-Apr; 23(2):488-493 [PubMed] Related Publications
METHODS: 80/95 patients underwent CRS plus HIPEC at the Metaxa Cancer Hospital, Piraeus, Greece from 06/2011 to 06/2015 and completed the colorectal version of the Functional Assessment of Cancer Therapy questionnaire (FACTC, version 4) at 1 week pre-operatively and at 1, 3, 6, 12, 18, 24 months post-operatively. The subscales assessed were the physical, social/family, emotional and functional wellbeing.
RESULTS: In all subscales, fluctuations in the scores indicated a worsening of QoL in the first 3 post-operative months, followed by improvement back to pre-operative levels and even better scores later on. Statistical improvement was proven for the physical and emotional well-being subscales.
CONCLUSIONS: The significant improvement in the physical well-being is attributed to the eradication of symptoms, whereas the relevant improvements in the emotional wellbeing subscale are explained both by the pre-operative desperation of the diagnosis or relapse of malignancy, and the post-operative hopefulness after a successful operation.
Exercise, supportive group therapy, and mood profile of Greek cancer patients: intervention effect and related comparisons.
Support Care Cancer. 2018; 26(10):3571-3578 [PubMed] Related Publications
METHODS: The sample consisted of 39 cancer patients (10 males and 29 females), randomly assigned to the three following groups: control, exercise and psychotherapy groups (13 patients in each group). The duration of the training program for the individuals of the exercise group was 10 weeks with two sessions per week, lasting 60 min each. The patients of the psychotherapy group received 10 weeks of supportive-expressive group therapy, once a week, 90 min long. The Profile of Mood States (POMS) questionnaire was administered to examine the short-term effect of both programs before and after intervention in terms of distinct mood states. Control group individuals did not participate in any program and they just filled in the POMS questionnaire before and after intervention.
RESULTS: Post hoc analysis revealed an anger reduction, as regards the supportive therapy group presenting statistically significant results from both the control group (- 6.91 units drop in anger subscale score, p < .001) and the exercise group (- 4.75 units drop in anger subscale score, p = .007). Regarding total POMS score, results also favored the supportive therapy group as compared to the control group (- 28.95 units drop in total POMS score, p = .001). Post-intervention values were also improved for the exercise group, but not to the extent to produce statistically significant results.
CONCLUSIONS: The findings of this study strongly support the beneficial effect of psychological intervention on anger and total mood score of patients with cancer, followed by the positive effect of the exercise program but not to the same extent as in the case of supportive therapy intervention.
Association of Skin Examination Behaviors and Thinner Nodular vs Superficial Spreading Melanoma at Diagnosis.
JAMA Dermatol. 2018; 154(5):544-553 [PubMed] Free Access to Full Article Related Publications
Objective: To investigate the association of SSE, PSE, and patient attitudes with the detection of thinner superficial spreading melanoma (SSM) and nodular melanoma (NM), the latter of which tends to elude early detection.
Design, Setting, and Participants: This cross-sectional, questionnaire-based, multicenter study identified patients with newly diagnosed cutaneous melanoma at 4 referral hospital centers in the United States, Greece, and Hungary. Among 920 patients with a primary invasive melanoma, 685 patients with SSM or NM subtype were included.
Interventions: A standardized questionnaire was used to record sociodemographic information, SSE and PSE practices, and patient perceptions in the year prior to diagnosis.
Main Outcomes and Measures: Data were analyzed according to histologic thickness, with a 2-mm cutoff for thinner SSM and NM.
Results: Of 685 participants (mean [SD] age, 55.6 [15.1] years; 318 [46%] female), thinner melanoma was detected in 437 of 538 SSM (81%) and in 40 of 147 NM (27%). Patients who routinely performed SSE were more likely to be diagnosed with thinner SSM (odds ratio [OR], 2.61; 95% CI, 1.14-5.40) but not thinner NM (OR, 2.39; 95% CI, 0.84-6.80). Self-detected clinical warning signs (eg, elevation and onset of pain) were markers of thicker SSM and NM. Whole-body PSE was associated with a 2-fold increase in detection of thinner SSM (OR, 2.25; 95% CI, 1.16-4.35) and thinner NM (OR, 2.67; 95% CI, 1.05-6.82). Patient attitudes and perceptions focusing on increased interest in skin cancer were associated with the detection of thinner NM.
Conclusions and Relevance: Our findings underscore the importance of complementary practices by patients and physicians for the early detection of melanoma, including regular whole-body PSE, SSE, and increased patient awareness.
Symptoms in Advanced Cancer Patients in a Greek Hospital: a Descriptive Study
Asian Pac J Cancer Prev. 2018; 19(4):1047-1052 [PubMed] Free Access to Full Article Related Publications
Views of cancer patients regarding cardiopulmonary resuscitation in Greece.
Eur J Cancer Care (Engl). 2018; 27(4):e12850 [PubMed] Related Publications
Dermoscopic features of melanocytic skin lesions in Greek children and adolescents and their association with environmental factors and skin types.
J Eur Acad Dermatol Venereol. 2018; 32(12):2142-2148 [PubMed] Related Publications
OBJECTIVE: In this study, we intend to determine the prevalence of dermoscopic patterns of naevi, as well their association with environmental and constitutional factors.
METHODS: Cross-sectional data derived from a population-based cohort of children and adolescents aged 6-18 years, from 12 different schools in Thessaloniki, Greece. For each participant, a consent form and a questionnaire were completed, which included data on age, sex, phototype, sun sensitivity, sun exposure, sunscreen use and previous sunburn history. All naevi, their body distribution, and their dermoscopic patterns were recorded.
RESULTS: Two thousand and five hundred and five (2505) subjects were enrolled into the study (47.8% males and 52.2% females). The mean number of MN counted in a single person was 29.11 (SD = ±23.863). TNC increased continuously with higher age. Males were found to have a significantly increased number on the trunk (11.7 ± 11.2 and 10.0 ± 8.7, respectively, P < 0.001) and face and neck (6.2 ± 5.3 and 5.1 ± 4.3, respectively, P < 0.001) while females on the upper (10.3 ± 10.1 and 9.3 ± 9.4, respectively, P = 0.008) and lower extremities (2.8 ± 3.4 and 2.5 ± 3.2, respectively, P = 0.008). Globular pattern was the most frequent dominant pattern in lower age groups, and its percentage fell as age increased. On the contrary, the reticular pattern was more often documented in individuals in adolescence.
CONCLUSION: This first study of MN in our young population aims to be the basis of further investigation for the MM preventive policy of our state.
Accuracy of dermoscopic criteria for the differentiation between superficial basal cell carcinoma and Bowen's disease.
J Eur Acad Dermatol Venereol. 2018; 32(11):1914-1919 [PubMed] Related Publications
METHODS: Dermoscopic images of histopathologically diagnosed sBCC and BD were evaluated by three independent investigators for the presence of predefined criteria. Subsequently, three independent investigators with expertise in dermoscopy classified the tumours as sBCC or BD based on the dermoscopic image. Diagnostic accuracy scores were calculated and crude and adjusted odds ratios, and 95% confidence intervals were calculated by univariate and conditional multivariate logistic regression, respectively.
RESULTS: A total of 283 lesions were included in the study (194 sBCCs and 89 BD). The main dermoscopic predictors of BD were dotted vessels (7.5-fold) and glomerular vessels (12.7-fold). The presence of leaf-like areas/spoke-wheel areas/concentric structures (OR = 0.027) and arborizing vessels (OR = 0.065) has predicted sBCC. Multivariate risk factors for sBCC misclassification were the location on lower extremities (OR = 5.5), the presence of dotted vessels (OR = 59.5) and the presence of large ulceration (OR = 6.4). In contrast, the presence of brown-coloured pigmentation was a protective predictor for misdiagnosis (OR = 0.007). Finally, a subgroup analysis of lesions located on lower extremities revealed two additional potent predictors of sBCC: superficial fine telangiectasia (SFT) and whity shiny blotches/strands.
CONCLUSIONS: Dotted and glomerular vessels are strong predictors of BD. When located on the lower extremities, sBCC may also display dotted vessels, rendering its recognition problematic. On the latter anatomic site, clinicians should consider SFT and whity shiny blotches/strands as additional sBCC predictors.
Clinical utility of miR-143/miR-182 levels in prognosis and risk stratification specificity of BFM-treated childhood acute lymphoblastic leukemia.
Ann Hematol. 2018; 97(7):1169-1182 [PubMed] Related Publications
Prognostic significance of EGFR and COX-2 expression in colorectal cancer and their association. A study in Greek population.
J BUON. 2018 Jan-Feb; 23(1):23-28 [PubMed] Related Publications
METHODS: Data from our department's prospectively collected database were retrieved for a total of 100 consecutive colectomies that were performed in our department. We examined patient age, sex, tumor stage and location of the tumor. Histological data were also retrieved concerning major tumor diameter, histological grade and immunohistochemical expression of cyclooxygenase (COX)-2 and epithermal growth factor receptor (EGFR).
RESULTS: There was no difference between tumors of different differentiation in the expression of EGFR (p=0.146), while there was statistically significant difference in the expression of COX-2 between these groups (p=0.001). There was no difference between these patients in the expression of EGFR (p=0.136), while a statistically significant difference was found in the expression of COX-2 between the same patient groups (p<0.005).
CONCLUSION: These data are quite important in order to certify that colorectal cancer molecular and genetic diversity between different study populations is not a confounding factor in the application and clinical implementation of trending individualized decision making in oncological treatments.
Real-world data on prognosis and outcome of primary plasma cell leukemia in the era of novel agents: a multicenter national study by the Greek Myeloma Study Group.
Blood Cancer J. 2018; 8(3):31 [PubMed] Free Access to Full Article Related Publications