Japan
Population in 2012: | 126.4m |
People newly diagnosed with cancer (excluding NMSC) / yr: | 703,900 |
Age-standardised rate, incidence per 100,000 people/yr: | 217.1 |
Risk of getting cancer before age 75: | 21.8% |
People dying from cancer /yr: | 378,600 |




Japan: Cancer Organisations and Resources (12 links)
がん登録全国協議会 | Japanese Association of Cancer Registries - English - English
JACR Founded 1992
九州肺癌研究機構 | Lung Oncology Group in Kyushu - 日本語 - Translate to English
A clinical research group founded in 2004, now with 89 collaborating institutions, running clinical trials in lung cancer.
公益財団法人 がん研究会 | Japanese Foundation For Cancer Research - English - English
Established in 1908 as the first institute in Japan specialized in cancer. Now includes the Cancer Institute and its affiliated hospital, Tokyo.
公益財団法人札幌がんセミナー | Sapporo Cancer Seminar Foundation - 日本語 - English
SCSF is a nonprofit corporation founded in 1981 and facilitates international symposia.
日本乳癌学会 | Japanese Breast Cancer Society - 日本語 - English
Founded 1992 encouraging study, research, education and training concerning with breast cancer for members and contribute to the public health.
日本婦人科腫瘍学会 | Japan Society of Gynecologic Oncology - 日本語 - English
JSGO
A non-profit professional organization, founded 1988.
日本癌治療学会 | Japan Society of Clinical Oncology - 日本語 - English
JSCO
A national professional organization founded in 1963 to advance the specialty of clinical oncology and promoting a multidisciplinary approach in cancer treatment and care.
日本肺癌学会 | Japan Lung Cancer Society - 日本語 - English
A non-profit organisation founded in 1960, promoting research on lung cancer and and helping to diffuse knowledge and understanding of the disease among society.
日本脳腫瘍学会 | Japan Society for Neuro-Oncology - 日本語 - English
JSNO is a society promoting professional development and international co-operation to advance neuro-oncology, established 1980.
日本脳腫瘍病理学会 | Japan Society of Brain Tumor Pathology - 日本語 - Translate to English
UICC member organisations: Japan
Union for International Cancer Control
Japan: Cancer Centres (6 links)
愛知県がんセンター | Aichi Cancer Center - 日本語 - English
Comprehensive Cancer Center and research institute located in Nagoya, founded in 1964.
東札幌病院 | Higashi Sapporo Hospital - 日本語 - Translate to English
A specialist cancer hospital
栃木県立がんセンター | Tochigi Cancer Center - 日本語 - Translate to English
Cancer centre located in Utsunomiya.
神奈川県立がんセンター | Kanagawa Cancer Centre - 日本語 - Translate to English
Cancer centre and Research Institute, founded in 1986.
静岡がんセンター | Shizuoka Cancer Center - English - English
Comprehensive cancer center, consisting of hospital, research institute, disease management center, established 2002 by Shizuoka Prefecture. The center also plays a role as an innovation complex in association with the Mount Fuji Pharma Valley Project.
Journals of Japanese Societies (5 links)
Annals of Cancer Research and Therapy
J-STAGE
Journal of the Japanese Society of Strategies for Cancer Research and Therapy (English language). The journal can be accessed via the Japan Science and Technology Information Aggregator, Electronic (J-STAGE).
Springer
Journal of the Japan Society of Brain Tumor Pathology. This international journal documents the latest research and topical debate in all clinical and experimental fields relating to brain tumors, especially brain tumor pathology.
Springer
Journal of the Japanese Breast Cancer Society. Publishes original articles that contribute to progress in the field, in basic or translational research and also in clinical research.
Japanese Journal of Clinical Oncology
Oxford University Press
Japanese Journal of Lung Cancer
Nippon Haigan Gakkai

Latest Research Publications related to Japan
Effect of allogeneic hematopoietic cell transplantation for patients with T-prolymphocytic leukemia: a retrospective study from the Adult Lymphoma Working Group of the Japan Society for hematopoietic cell transplantation.
Ann Hematol. 2019; 98(9):2213-2220 [PubMed] Related Publications
Initial Experience of Pembrolizumab Therapy in Japanese Patients With Metastatic Urothelial Cancer.
Anticancer Res. 2019; 39(7):3887-3892 [PubMed] Related Publications
PATIENTS AND METHODS: The medical records of 40 consecutive Japanese patients with metastatic UC who started pembrolizumab between January and October 2018 were reviewed and statistically analyzed to clarify the efficacy and safety of the drug.
RESULTS: The objective response rate, median progression-free survival period, and median overall survival period were 20.6%, 4.1 months and 10.0 months, respectively. Multivariate analysis indicated the presence of liver metastasis, worse performance status (≥2), and higher C-reactive protein as factors predictive of shorter OS.
CONCLUSION: We demonstrated for the first time, a comparable efficacy and safety profile of pembrolizumab for Japanese patients with metastatic UC, as in the KEYNOTE-045 study. The results indicate the features of pembrolizumab therapy in the current Japanese clinical practice.
Helicobacter pylori (HP) infection alone, but not HP-induced atrophic gastritis, increases the risk of gastric lymphoma: a case-control study in Japan.
Ann Hematol. 2019; 98(8):1981-1987 [PubMed] Related Publications
Serum Prognostic Factors of Androgen-deprivation Therapy Among Japanese Men With
Anticancer Res. 2019; 39(6):3191-3195 [PubMed] Related Publications
PATIENTS AND METHODS: This study included 104 patients with metastatic prostate cancer who were treated with primary androgen-deprivation therapy from 2001 to 2013. Clinicopathological factors including several serum markers were investigated for association with progression-free (PFS) and overall (OS) survival.
RESULTS: During a median follow-up of 48.1 months, median PFS and OS were 24.0 months and 67.4 months, respectively. When adjusted by age, prostate-specific antigen at diagnosis, Gleason score, and clinical stage, serum lactate dehydrogenase value was significantly associated with PFS [hazard ratio (HR)=1.42, 95% confidence interval (CI)=1.15-1.74; p=0.0004] and OS (HR=1.46, 95% CI=1.13-1.82; p=0.0014), in addition to alkaline phosphatase value for OS (HR=1.04; 95% CI=1.00-1.07; p=0.015).
CONCLUSION: This study demonstrates the prognostic significance of alkaline phosphatase and lactate dehydrogenase values in Japanese men with de novo metastatic hormone-sensitive prostate cancer.
Optimal Timing of Cabazitaxel Introduction for Japanese Patients With Metastatic Castration-resistant Prostate Cancer.
Anticancer Res. 2019; 39(6):3089-3094 [PubMed] Related Publications
PATIENTS AND METHODS: The clinical outcomes of 66 mCRPC patients receiving cabazitaxel following failure of docetaxel were retrospectively analyzed.
RESULTS: Among the parameters possibly affecting the timing of cabazitaxel introduction, only an increased prostate-specific antigen (PSA) value from the diagnosis of CRPC had a significant impact on overall survival (OS) after the introduction of cabazitaxel. Furthermore, there was a significant correlation between the increased PSA value from the diagnosis of CRPC and the baseline PSA value at cabazitaxel introduction. Multivariate analysis showed that only the baseline PSA value at cabazitaxel introduction is an independent predictor of OS.
CONCLUSION: A comparatively low PSA value could be an alternative index suggesting the optimal timing for cabazitaxel introduction.
Usefulness of Hematological Inflammatory Markers in Predicting Severe Side-effects from Induction Chemotherapy in Head and Neck Cancer Patients.
Anticancer Res. 2019; 39(6):3059-3065 [PubMed] Related Publications
MATERIALS AND METHODS: A total of 54 HNC patients who underwent IC were enrolled. The association between severe side-effects and pre-treatment hematological inflammatory markers [the C-reactive protein (CRP) to albumin ratio (CAR), the modified Glasgow Prognostic Score (mGPS), the neutrophil-to-lymphocyte ratio (NLR), and the platelet-to-lymphocyte ratio (PLR)] were evaluated.
RESULTS: In the univariate analysis, the incidence of whole severe side-effects (grade 4), febrile neutropenia (above grade 3), and hyponatremia (above grade 3) were significantly higher in the high CAR and high GPS groups. Multivariate analysis revealed that high CAR and mGPS were independent predictors of these side-effects.
CONCLUSION: CAR and mGPS were significant predictors of severe side-effects. These data can potentially offer patients an improved quality of life during cancer therapy.
Reevaluation of Preoperative Chemoradiotherapy for Clinical T3 Lower Rectal Cancer: A Multicenter Collaborative Retrospective Clinical Study.
Anticancer Res. 2019; 39(6):3047-3052 [PubMed] Related Publications
PATIENTS AND METHODS: Between 2010 and 2014, 132 patients with clinical T3 lower rectal cancer without lateral lymph node metastasis, 80 years of age or younger, who underwent curative resection at four Jikei University Hospitals were enrolled into this retrospective study. Of these, 22 patients received chemoradiotherapy (CRT) before surgery, 16 patients received intensive chemotherapy after surgery without preoperative CRT, and 94 patients underwent neither preoperative CRT nor intensive chemotherapy after surgery including 47 patients with postoperative oral chemotherapy for pathological diagnosis of stage III.
RESULTS: The 3-year disease-free survival (DFS) of the 22 patients who received preoperative CRT was 95.5%, whereas that of the 94 patients who received neither preoperative CRT nor intensive chemotherapy was 72.0% (p=0.024). However, there was no significant difference in 5-year DFS between the two groups. No significant difference was identified in DFS between the 22 patients who received preoperative CRT and the 16 patients who received intensive chemotherapy after surgery without preoperative CRT.
CONCLUSION: Intensive chemotherapy after surgery seems to yield a similar prognosis to preoperative CRT in patients with clinical T3 lower rectal cancer without lateral lymph node metastasis.
Mutational burden and signatures in 4000 Japanese cancers provide insights into tumorigenesis and response to therapy.
Cancer Sci. 2019; 110(8):2620-2628 [PubMed] Free Access to Full Article Related Publications
Potentials of C-C motif chemokine 2-C-C chemokine receptor type 2 blockers including propagermanium as anticancer agents.
Cancer Sci. 2019; 110(7):2090-2099 [PubMed] Free Access to Full Article Related Publications
The Japanese Lung Cancer Society Guideline for non-small cell lung cancer, stage IV.
Int J Clin Oncol. 2019; 24(7):731-770 [PubMed] Free Access to Full Article Related Publications
Evaluation of the Revised International Staging System (R-ISS) in Japanese patients with multiple myeloma.
Ann Hematol. 2019; 98(7):1703-1711 [PubMed] Related Publications
A Phase I Study of Napabucasin Plus Paclitaxel for Japanese Patients With Advanced/Recurrent Gastric Cancer.
In Vivo. 2019 May-Jun; 33(3):933-937 [PubMed] Free Access to Full Article Related Publications
PATIENTS AND METHODS: Patients received napabucasin (480 mg bid) plus paclitaxel [80 mg/m
RESULTS: Six patients were enrolled. Paclitaxel had a minimal effect on napabucasin pharmacokinetics and median plasma paclitaxel concentrations were similar in combination and monotherapy. No dose-limiting toxicities were observed. There were no grade 4/5 adverse events. Partial response, stable disease and progressive disease were reported in two patients each.
CONCLUSION: Napabucasin plus paclitaxel was well-tolerated in Japanese patients with gastric cancer.
Effects of preoperative oral management by dentists on postoperative outcomes following esophagectomy: Multilevel propensity score matching and weighting analyses using the Japanese inpatient database.
Medicine (Baltimore). 2019; 98(17):e15376 [PubMed] Related Publications
Physician requests by patients with malignant pleural mesothelioma in Japan.
BMC Cancer. 2019; 19(1):383 [PubMed] Free Access to Full Article Related Publications
METHODS: This cross-sectional survey was part of a larger study (N = 133) regarding the quality of life of MPM patients. Specific responses to two open-ended questions related to patients' requests regarding treatment and care were quantified, analyzed and divided into categories based on content.
RESULTS: Responses (N = 217) from MPM patients (N = 73) were categorized into 24 subcategories and then abstracted into 6 categories. The majority of requests were related to patient-physician communication. Patients wanted clear and understandable explanations about MPM and wanted their physician to deliver treatment based on the patient's perspective by accepting and empathizing with their anxiety and pain. Patients expected physicians to be dedicated to their care and establish an improved medical support system for MPM patients.
CONCLUSION: Patients with MPM had a variety of unmet needs from their physicians. Physicians who provide care to MPM patients should receive training in both communication skills and stress management. A multidisciplinary care system that includes respiratory and palliative care for MPM patients should be established.
Recent Status and Methodological Quality of Return-to-Work Rates of Cancer Patients Reported in Japan: A Systematic Review.
Int J Environ Res Public Health. 2019; 16(8) [PubMed] Free Access to Full Article Related Publications
Improved prognosis of extranodal NK/T cell lymphoma, nasal type of nasal origin but not extranasal origin.
Ann Hematol. 2019; 98(7):1647-1655 [PubMed] Related Publications
Coffee consumption and liver cancer risk in Japan: a meta-analysis of six prospective cohort studies.
Nagoya J Med Sci. 2019; 81(1):143-150 [PubMed] Free Access to Full Article Related Publications
Androgen receptor mRNA expression is a predictor for recurrence-free survival in non-muscle invasive bladder cancer.
BMC Cancer. 2019; 19(1):331 [PubMed] Free Access to Full Article Related Publications
METHODS: We retrospectively reviewed 53 specimens of non-metastatic NMIBC, with recurrence-free survival (RFS) as the primary endpoint. We used real-time quantitative polymerase chain reaction to quantify AR mRNA expression. Kaplan-Meier product-limit estimators were used to assess RFS distribution, log-rank tests to analyze differences in RFS between high- and low-risk groups; and multivariate analyses of AR mRNA expression and other clinicopathological factors to predict independent factors for RFS.
RESULTS: The high AR mRNA-expressing group (n = 43) tended to have a longer median RFS (not reached) than did the low-AR group (n = 10; 9.04 months; P = 0.112). Multivariate analysis showed female sex (hazard ratio [HR]: 7.360, 95% CI: 1.649-32.856, P = 0.009), tumor size ≥3 cm (HR: 23.697, 95% CI: 4.383-128.117, P < 0.001) and low AR mRNA expression (HR: 0.202, 95% CI: 0.048-0.841, P = 0.028) to be independent predictors of shorter RFS.
CONCLUSION: Our study showed that low AR mRNA expression level is an independent risk factor for RFS in Japanese patients with NMIBC. Further studies are necessary but AR expression might be a new indicator of recurrence of NMIBC.
Long-term follow up of nivolumab in previously untreated Japanese patients with advanced or recurrent malignant melanoma.
Cancer Sci. 2019; 110(6):1995-2003 [PubMed] Free Access to Full Article Related Publications
A Japanese multicenter phase II study of adjuvant chemotherapy with mFOLFOX6/CAPOX for stage III colon cancer treatment after D2/D3 lymphadenectomy.
Surg Today. 2019; 49(6):498-506 [PubMed] Related Publications
METHODS: Eligible patients were scheduled to receive 12 cycles of mFOLFOX6 or 8 cycles of CAPOX in adjuvant settings. The primary endpoint was the 3-year disease-free survival (DFS). Cox proportional hazards regression was performed to identify risk factors for a worse DFS.
RESULTS: A total of 130 patients, including 73 patients receiving mFOLFOX6 and 57 patients receiving CAPOX, were enrolled from 16 institutions between April 2010 and April 2014. The 3-year DFS was 82.2%, exceeding the expected primary endpoint of 81.7%. The 3-year DFS tended to be higher in patients receiving mFOLOFOX6 than in those receiving CAPOX (mFOLFOX6, 86.3%; CAPOX, 76.9%; P = 0.06). The 3-year DFS rates did not differ markedly based on the risk stratification (T1/T2/T3 N1 vs. T4 or N2) indicated by the IDEA COLLABORATION study (P = 0.22). In the multivariate analysis, stage IIIC (P = 0.046) and early discontinuation (P < 0.01) were identified as independent significant risk factors for a worse DFS.
CONCLUSION: Our findings represent the first positive results in a Japanese phase II trial of adjuvant chemotherapy with mFOLFOX6/CAPOX. Early discontinuation within 2 months was an independent risk factor for a shorter DFS.
The impact of emphysema on surgical outcomes of early-stage lung cancer: a retrospective study.
BMC Pulm Med. 2019; 19(1):73 [PubMed] Free Access to Full Article Related Publications
METHODS: The clinical records of 566 consecutive lung cancer patients who underwent pulmonary resection in our department were retrospectively reviewed. Among these, the data sets of 364 pathological stage I patients were available. The associations between the extent of lung emphysema and long-term outcomes and postoperative complications were investigated. Emphysema was assessed on the basis of semiquantitative CT. Surgery-related complications of Grade ≥ II according to the Clavien-Dindo classification were included in this study.
RESULTS: Emphysema was present in 63 patients. The overall survival and relapse-free survival of the non-emphysema and emphysema groups at 5 years were 89.0 and 61.3% (P < 0.001), respectively, and 81.0 and 51.7%, respectively (P < 0.001). On multivariate analysis, significant prognostic factors were emphysema, higher smoking index, and higher histologic grade (p < 0.05). Significant risk factors for poor recurrence-free survival were emphysema, higher smoking index, higher histologic grade, and presence of pleural invasion (P < 0.05). Regarding Grade ≥ II postoperative complications, pneumonia and supraventricular tachycardia were more frequent in the emphysema group than in the non-emphysema group (P = 0.003 and P = 0.021, respectively).
CONCLUSION: The presence of emphysema affects the long-term outcomes and the development of postoperative complications in early-stage lung cancer patients.
Nivolumab versus everolimus in advanced renal cell carcinoma: Japanese subgroup 3-year follow-up analysis from the Phase III CheckMate 025 study.
Jpn J Clin Oncol. 2019; 49(6):506-514 [PubMed] Related Publications
METHODS: Patients were randomized 1:1 to nivolumab 3 mg/kg intravenously every 2 weeks or everolimus 10 mg orally once daily until progression/intolerable toxicity. The primary endpoint was overall survival (OS). Key secondary endpoints included objective response rate, progression-free survival, safety and patient-reported quality of life.
RESULTS: Of 410 and 411 patients randomized to nivolumab and everolimus, 37 and 26 were Japanese, respectively. The median OS for the global population was 25.8 months with nivolumab and 19.7 months with everolimus (hazard ratio 0.74; 95.5% confidence interval [CI]: 0.63-0.88; P = 0.0005); in the Japanese population, median OS was 45.9 months and not reached (hazard ratio 1.08; 95% CI: 0.50-2.34; P = 0.85), respectively. The investigator-assessed objective response rate was 26% versus 5% with nivolumab versus everolimus (odds ratio [OR] 6.19; 95% CI: 3.82-10.06) in the global population and 43% versus 8% in the Japanese population (OR 6.80; 95% CI: 1.60-28.91; P = 0.0035), respectively. The incidence of any-grade treatment-related adverse events was lower with nivolumab versus everolimus in both the global patient population (80% versus 89%) and the Japanese population (81% versus 100%).
CONCLUSIONS: At the 3-year follow-up, the efficacy and safety results of CheckMate 025 are generally consistent in the global and the Japanese populations.
Protective effect of bevacizumab on chemotherapy-related acute exacerbation of interstitial lung disease in patients with advanced non-squamous non-small cell lung cancer.
BMC Pulm Med. 2019; 19(1):72 [PubMed] Free Access to Full Article Related Publications
METHODS: We analysed incidence of AE-ILD and outcomes of 48 patients with advanced non-squamous NSCLC with ILD who received first-line chemotherapy with (Bev group, n = 17) and without (non-Bev group, n = 31) Bev between July 2011 and July 2016. Gray's test, which was competing risk analysis during the study period, was performed for both groups.
RESULTS: The most common regimen used for first-line chemotherapy was the combination of carboplatin plus pemetrexed (PEM) in both groups. The incidences of chemotherapy-related AE-ILD 120 days after first-line chemotherapy initiation were significantly lower in the Bev than in the non-Bev groups (0% vs. 22.6%, p = 0.037, Gray's test). However, there were no differences in development of progressive disease of lung cancer and other events as the competing risk factors of AE-ILD between the two groups. Only patients receiving PEM-containing regimens also showed a significant difference in the incidence of AE-ILD between the two groups (p = 0.044). The overall-cumulative incidence of AE-ILD during the first-line and subsequent chemotherapy was 29.2% (14 of the 48). The median progression-free survival was significantly longer in the Bev than in the non-Bev groups (8.0 vs. 4.3 months, p = 0.026).
CONCLUSIONS: The addition of Bev to chemotherapy regimens may reduce the risk of chemotherapy-related AE-ILD in patients with lung cancer.
Review of ependymomas: assessment of consensus in pathological diagnosis and correlations with genetic profiles and outcome.
Brain Tumor Pathol. 2019; 36(2):92-101 [PubMed] Related Publications
A retrospective analysis of the prevalence of dental diseases in patients with digestive system cancers.
Medicine (Baltimore). 2019; 98(13):e14771 [PubMed] Free Access to Full Article Related Publications
Association of lenvatinib trough plasma concentrations with lenvatinib-induced toxicities in Japanese patients with thyroid cancer.
Med Oncol. 2019; 36(5):39 [PubMed] Related Publications
Prognostic Factors of Malignant Peritoneal Mesothelioma Experienced in Japanese Peritoneal Metastasis Center.
Gan To Kagaku Ryoho. 2019; 46(2):395-399 [PubMed] Related Publications
METHODS: Among 63 patients with MPM, male and female patients were 34 and 29. CRSwas performed in 47 patients and complete cytoreduction(CC-0) was performed in 14(22%)patients. Mean numbers of resected peritoneal sectors and organs were 5.2(1-13), and 2.9(0- 9), respectively. Hyperthermic intraperitoneal chemoperfusion(HIPEC)was performed in 27 patients. Grade 1/2, Grade 3, and Grade 4 complications were experienced in 5, 6, and 3 patients, respectively. One patient died of sepsis, and the mortality rate was 2.3%. Independent prognostic factors for favorable prognosis were performance of HIPEC, peritoneal cancer index (PCI)score C12, no distant metastasis and histologic epithelial type. Relative risk of no HIPEC, PCI score B13, presence of distant metastasis and non epithelial type were 7.69, 22.1, 3.6 and 3.9, respectively.
CONCLUSIONS: Risk factors for death after comprehensive treatment were no HIPEC, PCI score B13, and non epithelial type. However, only 11(17%)patients showed PCI score C12. Accordingly, PCI score should be reducedC12 before CRSby neoadjuvant chemotherapy.
Analysis of Treatment Failure after Complete Cytoreductive Surgery for Peritoneal Metastasis from Appendiceal Mucinous Neoplasm at a Japanese High Volume Center for Peritoneal Surface Malignancy.
Gan To Kagaku Ryoho. 2019; 46(2):251-258 [PubMed] Related Publications
METHODS: A total of 400 patients with AMCP who underwent complete cytoreductive surgery combined with perioperative chemotherapy were investigated.
RESULTS: Documented recurrence was developed in 135 (33.8%)patients. The 5- and 10-year progression-free survival was 51% and 49%, respectively. By multivariate analysis, histological subtype of peritoneal disease(high-grade AMCP[AMCP-H]and AMCP-H with signet ring cells), serum CA19- 9 level, and PCIB20 were significantly associated with reduced progression-free survival. In contrast, histologic subtype of mucin without epithelial cells(MWEC)showed the lowest risk for recurrence. Eighty-six patients had localized intra-abdominal recurrence, and 42 patients had diffuse peritoneal recurrence. Recurrence was found in the various peritoneal sectors. Eighty-one patients underwent complete cytoreduction for the recurrence, and the overall survival 5-year survival rate after secondary cytoreduction was 49%.
CONCLUSIONS: Risk factors for recurrence were histologic subtype, PCI cutoff level, and serum CA19-9 levels. Aggressive second attempt of cytoreduction in patients with localized recurrence improved the survival.
The Prefectural Participation Rates of Lung Cancer Screening Had a Negative Correlation with the Lung Cancer Mortality Rates
Asian Pac J Cancer Prev. 2019; 20(3):855-861 [PubMed] Related Publications
Impact of Diarrhea after Drinking on Colorectal Tumor Risk: A Case Control Study
Asian Pac J Cancer Prev. 2019; 20(3):795-799 [PubMed] Related Publications