The Chemotherapy and Pharmacology Page

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Chemotherapy is the treatment of diseases such as cancer with drug therapy. Since the 1960's the development and use of drugs has significantly improved the prognosis for some types of cancer. Chemo- means chemicals, for most types of cancer chemotherapy will consist of a number of different drugs, this is known as combination chemotherapy. Chemotherapy may be given in a variety of ways; Intravenously (IV) -into a vein is the most common, Intramuscularly (IM) -injection into a muscle, Orally -by mouth, Subcutaneously (SC) -injection under the skin, Intralesionally (IL) directly into a cancerous area, Intrathecally (IT)-into the fluid around the spine, or Topically -medication will be applied onto the skin. Menu: The Chemotherapy and Pharmacology Page General Information for the Public Personal Accounts of Chemotherapy Information for Health Professionals Specific Drugs Toxicity / Side Effects Pharmacy / Pharmacology Pharmaceutical Companies Hematopoitic Growth Factors Biological Responce Modifiers Vincristine Ifosfamide Etoposide Taxol General Information for the Public (7 links) Care of a skin-tunnelled catheter (Royal Marsden Hospital, UK) An on-line patient booklet. Chemotherapy (Royal Marsden Hospital, UK) An on-line patient booklet. Chemotherapy and You (OncoLink) Close Friends - Central Line Catheter Covers (Kendal and Co, Ohio, USA) A choice of cheerful covers designed to make central lines less intimidating, invented by the parent of a child with Hodgkin's disease. A portion of proceeds are donated to A Special Wish, Inc. Check with your doctor first. Conference: Commercial Issues in Oncology Drug Development, London 23-24 Sept 2000 More details at the SMi conferences web site. Understanding Adjuvant Chemotherapy by Kevin Murphy (part of CancerGuide) Understanding Chemotherapy (BACUP, UK) An on-line booklet See also Chemotherapy Menu See also National and International Organisations See also Disease Specific Resources See also Clinical Trials Personal Accounts of Chemotherapy (2 links) Usry's home page - photographs and journal of Vutheary's experience with bone cancer (USA) Usry is an artist and has dedicated much of her web site to her friend Vutheary who is aged 18 and has bone cancer. Each page contains a photograph and text journaling aspects of Vutheary's treatment with chemotherapy. Visualisations from Planet Blortland by Diana Hinnrichs -a patient with Hodgkin's Disease. This is her story: coping with chemotherapy etc. See also Chemotherapy Menu See also Patient's Home Pages Information for Health Professionals (22 links) Adjuvant systemic therapy for women with node-negative breast cancer (Health Canada) Clinical practice guidelines for the care and treatment of breast cancer - July 1, 1997 Anti-Cancer Drug Design (Oxford University Press) Anti-Cancer Drugs (Journal) subscription information only (at 09/1999) Antimicrobial Agents and Chemotherapy A journal of the American Society for Microbiology Antineoplastic Agents Generic Abbreviations (Medicine OnLine, USA) Cancer Biotechnology Weekly (USA) Cancer Chemotherapy and Pharmacology (Journal) the journal addresses pharmacologic and oncologic issues on both experimental and clinical levels. The main focus is on new anticancer agents. The site includes contents, abstracts and PDF files. Cancer Drugs: Daily News (NewsPage) Todays research news Center for Drug Development Science Georgetown University Medical Center, USA Chemotherapy (Journal) Chemotherapy for non-small cell lung cancer (Cochrane Collaboration) Synopsis and abstract of a systematic review. Database of Chemotherapeutic Regimens (Medicine OnLine, USA) drug regimes sorted by disease type Drug Delivery The Journal of Delivery and Targeting of Therapeutic Agents Drug Metabolism Guide (Glaxo Wellcome) Drug Resistance Updates (Journal) reviews and commentaries on developments in drug resistance in infectious disease and cancer including both basic research and clinical aspects. Homing In on Cancer Cells (Medical Science Bulletin, Pharminfo) Investigational New Drugs Liposome Drug Delivery Systems Homepage By Rajesh Krishna who is researching the use of liposomes to overcome multidrug resistance in cancer. Contains information about liposomes and links to related sites. (University of British Columbia) Medical Science Bulletin - Oncology Review Section Information for Oncologists (Pharminfo) Pharmacogenetics (Journal) Physician's information for Investigational or Newly Approved Drugs (CancerNet) RXList - Internet Drug Index RXList is a HealthCentral.com Network site with searchable database of drugs with drug monographs, patient information, medical dictionary, drug specific discussions and ordering information. See also Chemotherapy Menu See also Pharmacy / Pharmacology See also Clinical Trials See also Health Professional's Menu Specific Drugs (16 links) Etoposide Ifosfamide Taxol Vincristine Other drug specific information is listed below: About Tamoxifen (CancerNet) Cisplatin (Cheshire Medical Center, USA) Tamoxifen (Royal Marsden Hospital, UK) An on-line patient booklet. Tamoxifen for relapse of ovarian cancer (Cochrane Collaboration) Abstract of a systematic review. Tamoxifen Trials (Medical Science Bulletin, Pharminfo) ********** Information for Health Professionals *********** Guidance on Gemcitabine for Pancreatic Cancer A detailed technology appraisal by the National Institute for Clinical Excellence (NICE). First issued in May 2001. Guidance on Temozolomide in Recurrent Malignant Glioma. A detailed technology appraisal by the National Institute for Clinical Excellence (NICE). First issued in April 2001. Guidance on the use of docetaxel, paclitaxel, gemcitabine and vinorelbine for the treatment of non-small cell lung cancer. A detailed technology appraisal by the National Institute for Clinical Excellence (NICE). First issued in June 2001. Guidance on the use of fludarabine for B-cell chronic lymphocytic leukaemia A detailed technology appraisal by the National Institute for Clinical Excellence (NICE). First issued in September 2001. Guidance on the Use of Taxanes for Breast Cancer A detailed technology appraisal by the National Institute for Clinical Excellence (NICE). First issued in May 2000. Guidance on Topotecan for Ovarian Cancer A detailed technology appraisal by the National Institute for Clinical Excellence (NICE). First issued in August 2001. Guidance on Use of Taxanes for Ovarian Cancer A detailed technology appraisal by the National Institute for Clinical Excellence (NICE). First issued in May 2001. NIH Clinical Alert: Adjuvant Therapy of Breast Cancer - Tamoxifen Update Paclitaxel Plus Carboplatin Shows Promise in Advanced NSCLC Physician's info Low-dose IFN-alpha as Effective as High-dose for Chronic Myeloid Leukemia (Medical Science Bulletin, Pharminfo) USP Drug Database United States Pharmacopeia - a database of thousands of drugs referenced by brand names, generic name and category with information about usage, side effects and precautions. See also Chemotherapy Menu Toxicity / Side Effects (5 links) About Neupogen (R) (AMGEN) Neupogen is Amgen's granulocyte colony-stimulating factor (G-CSF). The drug stimulates the production of infection-fighting white blood cells which may be supressed after chemotherapy. Chemotherapy and Your Mouth (National Oral Health Information Clearinghouse, USA) This is an illustrated online booklet about the side effects that chemotherapy can have on your mouth and teeth and tips on how to deal with them. Prevention of oral mucositis or oral candidiasis for patients with cancer receiving chemotherapy (excluding head and neck cancer) (Cochrane Collaboration) Synopsis and abstract of a systematic review. ********** Information for Health Professionals *********** Drug: Granisetron (Kytril) Approved for Chemotherapy-induced Vomiting (Pharminfo) Physician's statement for Antiemetic Therapy (START, European School of Oncology) Referenced statement including a sections on prevention iof Emesis induced by chemotherapy, induced by radiotherapy, and emesis prevention in children. [Go to Chapters] See also Chemotherapy Menu See also Supportive Care Pharmacy / Pharmacology (22 links) American Association of Pharmaceutical Scientists American Pharmaceutical Association (APhA) American Society for Clinical Pharmacology and Therapeutics British Journal of Pharmacology A journal of the British Pharmacological Society British National Formulary, The (UK) The BNF is produced by the British Medical Association and the Royal Pharmaceutical Society of Great Britain. The Web site has search facility and contains detailed information about drugs and their administration and side effects, interactions etc. British Oncology Pharmacy Association (UK) A professional organisation, founded in 1996, for pharmacists, pharmacy technicians, people working in the pharmaceutical industry and other healthcare professions. The Web site includes publications / position statements, diary and newsletter etc. Canadian Association of Pharmacy in Oncology (Canada) CAPhO is the national forum for oncology pharmacy practitioners. The site includes a public area and a private members area. Canadian Society for Pharmaceutical Sciences (CSPS) a non-profit organization which was established in 1996 to promote pharmaceutical research. The site includes the electronic Journal of Pharmacy and Pharmaceutical Sciences. Clinical Pharmacology Online Includes a searchable database of generic and brand name drugs with specific details including dosage, contraindications, drug interactions, adverse reactions etc. Drug Metabolism and Excretion Homepage by L. Lichtblau, Ph.D. , Department of Pharmacology, University of Minnesota Medical School EUDRANET (European Commission, Technical Office for Medicinal Products) Network Services for the European Union Pharmaceutical Regulatory Sector International Society of Oncology Pharmacy Practitioners ISOPP was founded in 1995. The web site includes news, symposia, members area and link to the Society's publication: Journal of Oncology Pharmacy Practice. Journal of Oncology Pharmacy Practice publication of the International Society of Pharmacy Practitioners Journal of Pharmaceutical Sciences Journal of the American Chemical Association Laboratory of Medicinal Chemistry - National Cancer Institute (USA) LMCh is part of the NCI Division of Basic Sciences, it conducts research directed at the discovery and development of new anticancer and anti-HIV drugs LMCh consists of the sections of Organic Chemistry and Analytical Chemistry. Laboratory of Molecular Pharmacology (National Cancer Institute, USA) The laboratory conducts research into the relationships between molecular and cellular biology alterations involved in carcinogenesis. The Web site includes details of the project areas in the lab. Medical Pharmacology Units Detailed teaching material developed by Associate Prof Michael Gordon (KUMC). There are units on principles of pharmacology, chemotherapy, toxicology, body systems (autonomic, endocrine, GI, cardiovascular etc.) and drug info. Medication Info Search Database (Cheshire Medical Center, USA) Meta Index of Pharmacy / pharmacology Lists (Hardin Meta Directory of Internet Health Sources) PharmWeb (UK Mirror) Pharmacy Information Resources (International Collaboration) PharmWeb (Parent site - USA) Pharmacy Information Resources (International Collaboration) PharmWeg Yellow Pages Full of pharmacology / pharmaceutical links See also Chemotherapy Menu See also Pharmaceutical Companies Pharmaceutical Companies (28 links) This sub-list contains links to some commercial pharmaceutical companies involved with chemotherapy and research for oncology - it is not a complete listing of such companies. This list is for research purposes only, and inclusion here does not imply endorsement or preference for any particular company. Agouron Pharmaceuticals America's Pharmaceutical Research Companies PhRMA membership represents approximately 100 U.S. pharmaceutical research companies. The Web site includes FAQs and health and research news. Amgen Amgen Roche Site of the pharmaceutical company - includes a patient centre (with cancer links), Research centre, and information about other aspects of the company. Association of the British Pharmaceutical Industry (UK) an organisation covering about 80 companies. Aventis Oncology Aventis Pharmaceuticals (formerly Rhone-Poulenc Rorer Pharmaceuticals Inc. and Hoechst Marion Roussel, Inc.) Bayer Boehringer Ingelheim Bristol-Myers Squibb Cell Therapeutics, Inc. (CTI) (USA) A pharmaceutical company based in Seattle Chugai (UK) Pharmaceutical company EntreMed (USA) a pharmaceutical company focus on developing and commercial antiangiogenic drugs for use in treating cancer and other medical disorders. The web site includes information on angiogenesis, clinical trials etc. Glaxo Wellcome (UK) Pharmaceutical company Isis Pharmaceuticals Knoll Pharmaceutical Company Life Sciences Companies (Links for Chemists) a large alphabetical llist of links to life science companies NeoRx A company developing inovative pharmaceutical products primarily focusing on cancer. The site includes details of clinical programs and clinical trials. Novartis Pharmaceutical and Healthcare Companies (Links for Chemists) a large alphabetical llist of links to pharmaceutical companies. Pharmaceutical Industry: Daily News (NewsPage) Todays research news Pharmaceutical Links by Michael Williams, Chugai Pharmacia Corporation Precision Therapeutics, Inc (Pittsburgh, USA) a biomedical company, founded in 1995 which focuses on the interaction of tumor cells with chemotherapy and immunology-based drugs - including a proprietary library of patient-specific cell-lines using its ChemoFxAssaySM Roche Schering-Plough SmithKline Beecham YAHOO: Pharmaceutical companies Zeneca See also Chemotherapy Menu See also Pharmacy / Pharmacology Hematopoitic Growth Factors (1 link) Investigational Hematopoietic Growth Factors (OncoLink) See also Chemotherapy Menu Biological Responce Modifiers (2 links) Biological Response Modifiers (OncoLink) This page provides an introduction to BRMs, overview of the immune system, and summaries of different types of BRMs; monoclonal antibodies, Interferons, Interlukin-2, colony stimulating factors, and tumour necrosis factor. International Society for Interferon and Cytokine Research (ISICR) Information about the society, links, conferences, and the Cytokine-Interferon Open Forum for electronic discussion. See also Chemotherapy Menu See also Cancer Immunology and Immunotherapy Vincristine (2 links) Biodiversity's Contribution to Medicine- The Rosy Periwinkle (Cantharanthus roseus) (World Resource Institute) Vinca alkaloids (such as vincristine) are derived from this plant. Vincristine (BACUP, UK) Patient's Factsheet Medline Search: Vincristine (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews] See also Chemotherapy Menu See also Other Drugs Ifosfamide (2 links) Debate Over Ifosfamide Ifosfamide (BACUP, UK) Patient's Factsheet Medline Search: Ifosfamide (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews] See also Chemotherapy Menu See also Other Drugs See also Cytochromes and Ifosfamide Activation Etoposide (2 links) Etoposide (BACUP, UK) Patient's Factsheet Etoposide for Non-Hodgkin's Lymphoma in the Elderly Medline Search: Etoposide (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews] See also Chemotherapy Menu See also Other Drugs Taxol (1 link) Taxol (BACUP, UK) Patient's Factsheet Medline Search: Taxol (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews] Medline Search: Taxol and Breast Cancer (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews] See also Chemotherapy Menu See also Other Drugs